Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:


    1. Published

      2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

      Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection

      Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

      Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, Mette, Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

      Sun, W., Chen, L-N., Zhou, Q., Zhao, L-H., Yang, D., Zhang, H., Cong, Z., Shen, D-D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W. J. C., Zhao, S., Jiang, Y., Rosenkilde, M. M., Xu, H. E., Zhang, Y. & 1 others, Wang, M., 2020, In: Cell Research. 30, 12, p. 1098-1108

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

      Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published
    9. Published

      Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022

      Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

      Research output: Contribution to journalEditorialResearchpeer-review

    10. Published

      Advances in incretin-based therapeutics for obesity

      Rosenkilde, Mette, 2024, In: Nature Reviews Endocrinology. 20, p. 67–68 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

      Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

      Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial

      Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, E., Xue, K., Giller, K., Becker, S., Mujezinovic, A., Bentzen, Bo Hjorth, Andreas, L. B., Kolocouris, A., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Communications Biology. 4, 10 p., 1347.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

      Madsen, Thomas Daugbjerg, Hansen, L. H., Hintze, John, Ye, Z., Jebari, S., Andersen, Daniel Bjørklund, Joshi, Hiren Jitendra, Ju, T., Goetze, Jens P. , Martin, C., Rosenkilde, Mette, Holst, Jens Juul, Kuhre, Rune Ehrenreich, Goth, C. K., Vakhrushev, Sergey & Schjoldager, Katrine Ter-Borch Gram, 2020, In: Nature Communications. 11, 1, 13 p., 4033.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

      Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28

      Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

      Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

      Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

      Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

      Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2

      Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7

      Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Biased and g protein-independent signaling of chemokine receptors

      Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

      Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

      Research output: Contribution to journalReviewResearchpeer-review

    27. Published

      Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

      Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5

      Berg, Christian, Spiess, Katja, von Lüttichau, H. R. & Rosenkilde, Mette, Dec 2016, In: Pharmacology Research & Perspectives. 4, 6, 14 p., e00262.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published
    30. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Chapter 8. Activation mechanisms of chemokine receptors

      Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

      Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

      Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

      Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists

      Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.

      Research output: Contribution to journalConference abstract in journalResearchpeer-review

    36. Published
    37. Published

      Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V

      Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Constitutive and regulated activities of virus-encoded 7TM receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

      Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

    39. Published

      Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

      Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

      Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes

      Berg, Christian, Friis, M. B., Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Lüttichau, H. R. & Sundelin, T., 2019, In: PLoS ONE. 14, 9, 14 p., e0222053.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Development of potent and proteolytically stable human neuromedin U receptor agonists

      De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

      Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Differential regulation of CXCR4 and CCR5 endocytosis

      Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2

      Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

      Fares, S., Spiess, Katja, Olesen, Emma Tina Bisgaard, Zuo, J., Jackson, S., Kledal, T. N., Wills, M. R. & Rosenkilde, Mette, 2019, In: mBio. 10, 1, e01707-18.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

      Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans

      Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Published

      Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats

      Pedersen, C., Bouman, S. D., Porsgaard, T., Rosenkilde, Mette & Roed, N. K., 2018, In: Physiological Reports. 6, 6, 9 p., e13657 .

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      EBI2 in splenic and local immune responses and in autoimmunity

      Barington, L., Wanke, F., Niss Arfelt, K., Holst, Peter Johannes, Kurschus, F. C. & Rosenkilde, Mette, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 313-322 10 p.

      Research output: Contribution to journalReviewResearchpeer-review

    53. Published

      EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies

      Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

      Nørregaard, K., Benned-Jensen, T. & Rosenkilde, Mette, 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      EBV, the Human Host, and the 7TM Receptors: Defense or Offense?

      Arfelt, K. N., Fares, S. & Rosenkilde, Mette, 2015, The Molecular Basis of Viral Infection. Klasse, P. J. (ed.). Academic Press, Vol. 129. p. 395-427 (Progress in Molecular Biology and Translational Science, Vol. 129).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    56. Published

      Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

      Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, Jacob, Jonsson, G., Aarøe, J., Gasbjerg, Lærke Smidt, Rosenkilde, Mette & Gögenur, Ismail, Dec 2017, In: Journal of Cardiovascular Translational Research. 10, 5-6, p. 470-479 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    57. Published

      Effects of endogenous GIP in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    58. Accepted/In press

      Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

      Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

      Research output: Contribution to journalJournal articleResearchpeer-review

    59. Published
    60. Published

      Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.

      Research output: Contribution to journalConference abstract in journalResearch

    61. Published

      Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system

      Gabe, M. B. N., van der Velden, W. J. C., Gadgaard, S., Smit, F. X., Hartmann, Bolette, Bräuner, Hans & Rosenkilde, Mette, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 122-132

      Research output: Contribution to journalJournal articleResearchpeer-review

    62. Published

      Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice

      Gobron, B., Bouvard, B., Vyavahare, S., Blom, L. V. V., Pedersen, K. K., Windeløv, Johanne Agerlin, Boer, G. A., Harada, N., Zhang, S., Shimazu-Kuwahara, S., Wice, B., Inagaki, N., Legrand, E., Flatt, P. R., Chappard, D., Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette, Irwin, N. & Mabilleau, G., 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1363-1374 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    63. Published

      Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor

      Paulsen, S., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46

      Research output: Contribution to journalJournal articleResearchpeer-review

    64. Published

      Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality

      Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.

      Research output: Contribution to journalJournal articleResearchpeer-review

    65. Published

      Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor

      Paulsen, S. J., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    66. Published

      Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action

      de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218

      Research output: Contribution to journalJournal articleResearchpeer-review

    67. Published

      Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

      Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.

      Research output: Contribution to journalReviewResearchpeer-review

    68. Published

      Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin

      Ribeiro, R. V. P., Ku, T., Wang, A., Pires, L., Ferreira, V. H., Michaelsen, V., Ali, A., Galasso, M., Moshkelgosha, S., Gazzalle, A., Jeppesen, Mads Gravers, Rosenkilde, Mette, Liu, M., Singer, L. G., Kumar, D., Keshavjee, S., Sinclair, J., Kledal, T. N., Humar, A. & Cypel, M., 2022, In: Journal of Heart and Lung Transplantation. 41, 3, p. 287-297

      Research output: Contribution to journalJournal articleResearchpeer-review

    69. Published

      Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

      Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

      Research output: Contribution to journalJournal articleResearchpeer-review

    70. Published

      Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5

      Rummel, P. C., Thiele, S., Gasbjerg, Lærke Smidt, Petersen, T. P., wbf943, wbf943, Ulven, T. & Rosenkilde, Mette, 13 Jun 2013, In: Current Molecular Pharmacology. 84, 3, p. 335-345 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    71. Published

      Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo

      Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, Mette, Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    72. Published

      Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

      Spiess, Katja & Rosenkilde, Mette, 2014, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Stevens, C. W. (ed.). Humana Press, p. 45-64 20 p. (Methods in Pharmacology and Toxicology).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    73. Published

      G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications

      Goth, C. K., Petaja-Repo, U. E. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 237-245

      Research output: Contribution to journalReviewResearchpeer-review

    74. Published

      G protein-coupled receptor pharmacology-The next generation

      Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

      Research output: Contribution to journalEditorialResearch

    75. Published

      GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals

      Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e725-e738 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    76. Published

      GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

      Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.

      Research output: Contribution to journalJournal articleResearchpeer-review

    77. Published
    78. Published

      GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

      wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88

      Research output: Contribution to journalJournal articleResearchpeer-review

    79. Published
    80. Published

      GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

      Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75

      Research output: Contribution to journalJournal articleResearchpeer-review

    81. Published

      GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology

      Rosenkilde, Mette, Lindquist, Peter, Kizilkaya, Hüsün Sheyma & Gasbjerg, Lærke Smidt, 1 Apr 2024, In: Peptides. p. 171212

      Research output: Contribution to journalJournal articleResearchpeer-review

    82. Published

      GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

      van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    83. Published

      GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation

      Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.

      Research output: Contribution to journalJournal articleResearchpeer-review

    84. Published

      GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men

      Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185

      Research output: Contribution to journalJournal articleResearchpeer-review

    85. Published

      GPR119 as a fat sensor

      Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    86. Published

      GPR162 is a beta cell CART receptor

      Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.

      Research output: Contribution to journalJournal articleResearchpeer-review

    87. Published

      GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

      Bartlett, S., Gemiarto, A. T., Ngo, M. D., Sajiir, H., Hailu, S., Sinha, R., Foo, C. X., Kleynhans, L., Tshivhula, H., Webber, T., Bielefeldt-Ohmann, H., West, N. P., Hiemstra, A. M., MacDonald, C. E., Christensen, Liv von Voss, Schlesinger, L. S., Walzl, G., Rosenkilde, Mette, Mandrup-Poulsen, Thomas & Ronacher, K., 2020, In: Frontiers in Immunology. 11, 11 p., 601534.

      Research output: Contribution to journalJournal articleResearchpeer-review

    88. Published

      GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

      Foo, C. X., Bartlett, S., Chew, K. Y., Ngo, M. D., Bielefeldt-Ohmann, H., Arachchige, B. J., Matthews, B., Reed, S., Wang, R., Smith, C., Sweet, M. J., Burr, L., Bisht, K., Shatunova, S., Sinclair, J. E., Parry, R., Yang, Y., Lévesque, J. P., Khromykh, A., Rosenkilde, M. M. & 2 others, Short, K. R. & Ronacher, K., 2023, In: The European respiratory journal. 61, 3, 15 p., 2201306.

      Research output: Contribution to journalJournal articleResearchpeer-review

    89. Published

      GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity

      Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.

      Research output: Contribution to journalJournal articleResearchpeer-review

    90. Published

      Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

      Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    91. Published

      GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    92. Published

      GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    93. Published
    94. Published

      Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

      Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    95. Published

      Glucose and Amino Acid Metabolism in Mice Depend Mutually on Glucagon and Insulin Receptor Signaling

      Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Rosenkilde, Mette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E660-E673

      Research output: Contribution to journalJournal articleResearchpeer-review

    96. Published

      Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes

      Christensen, Mikkel Bring, Calanna, S., wbf943, wbf943, Kristensen, P. L., Rosenkilde, Mette, Faber, Jens, Purrello, F., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Jan 2015, In: Diabetes. 64, 1, p. 72-78 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    97. Published

      Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.

      Research output: Contribution to journalConference abstract in journalResearch

    98. Published

      Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

      Gasbjerg, Lærke Smidt, Gabe, M. B. N., Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Feb 2018, In: Peptides. 100, p. 173-181

      Research output: Contribution to journalJournal articleResearchpeer-review

    99. Published

      Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice

      Boer, G. A., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Sparre-Ulrich, A. H., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4486-4499

      Research output: Contribution to journalJournal articleResearchpeer-review

    100. Published

      Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

      Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, Mette, Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2018, In: Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631

      Research output: Contribution to journalJournal articleResearchpeer-review

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