Inflammation, Metabolism and Oxidation
Blegdamsvej 3, København N.
Thomas Mandrup-Poulsen is a physician scientist, specialist in internal medicine and endocrinology. He is a pioneer in the field of immuno-metabolism with the discovery that inflammatory cytokines impair the function and viability of pancreatic islet b-cells [1, 2], for which he was awarded the 1994 Minkowski Prize of the EASD. His research focuses on the mechanisms of action of pro-inflammatory cytokines, metabolites and oxidative stress causing islet cell damage in diabetes and how this can be prevented, employing in silico, in vitro, ex vivo and in vivo studies, animal diabetes models and clinical trials in diabetic patients. He and colleagues conducted the first proof-of-concept clinical trial showing that pro-inflammatory cytokine antagonists improve glycemia and b-cell function in diabetic patients [3, 4]. His expertise covers basic molecular and cellular techniques in b-cell biology, stress signalling, genomics and proteomics, epigenetics, animal models, clinical intervention trials and pharmaco-genomic and biochemical biomarker studies. >370 publications e.g. in Science, Lancet, N Engl J Med, Cell Metabolism, J Clin Invest, Proc Natl Acad Sci USA, J Immunol, J Biol Chem, Diabetes and Diabetologia. Reviews and commentaries in e.g. Nature Immunology, Nature Rev Endocrinol, Nature Clin Pract Endocrinol Metab, Nature Study, British Medical Journal, Diabetes and Diabetologia. H-index 64. Citations >14,500. >70 invited international lectures. Wide collaborative network in Europe, North America and Australia. Leading PI or co-PI of EU and JDRF grants, 3 international multicenter clinical studies, Chair of the TRIGR-trial DSMB, Advisory board member in international multicenter studies.
Primary fields of research
Immuno-endocrinology and immuno-metabolism
Mechanisms of action of pro-inflammatory cytokines, metabolites and oxidative stress causing islet cell damage in diabetes and how this can be prevented.
Fields of interest
Basic molecular and cellular studies in b-cell biology, stress signalling, genomics and proteomics, epigenetics, animal models, clinical intervention trials and pharmaco-genomic and biochemical biomarker studies.
Molecular biomedicine, endocrinology