Inflammation, Metabolism and Oxidation
We study inflammatory, oxidative and metabolic mechanisms behind non-communicable diseases, with a particular focus on cardiovascular disease and diabetes. We aim to advance the understanding of the pathophysiology of these diseases and identify novel preventive measures and therapeutic targets.
We quantify and examine the mechanisms, inhibition and the biological consequences of protein oxidation, at a chemical, molecular, cellular, organismal and human level. We assess how this, and other types of oxidative modification, are involved in both normal physiology and in human disease.
We study how pancreatic beta-cell survival and function, including proinsulin folding, are affected by aging and by immune, inflammatory, metabolic and oxidative stress in vitro and in vivo.
We apply translational approaches to understand how changes in transport, metabolism and oxidation of nutrients can lead to human diseases, and we study the mechanisms behind protein modifications in food products and their effects on food quality and health.
For more information on the topics and methods, please visit the group sites of our theme members.