Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools
Original languageEnglish
Title of host publicationG Protein-Coupled Receptor Genetics : Research and Methods in the Post-Genomic Era
EditorsCraig W. Stevens
Number of pages20
PublisherHumana Press
Publication date2014
ISBN (Print) 978-1-62703-778-5
Publication statusPublished - 2014
SeriesMethods in Pharmacology and Toxicology

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