Charlotte Mehlin Sorensen
Renal and Vascular Research
Blegdamsvej 3, 2200 København N.
Charlotte Mehlin Sørensen has a bachelor in Biology and a Master in Human Biology from University of Copenhagen. She started in the lab of Associate Professor Paul Peter Leyssac as a Master student working on renal autoregulation and the renin-angiotensin system. She proceeded to finish her PhD in the lab of Professor Niels-Henrik Holstein-Rathlou investigating changes in renal autoregulation during hypertension. After obtaining the PhD degree she was employed at Department of Pharmacology as Assistant Professor and subsequently as Assistant Professor at Department of Biomedical Sciences. During one year leave of absence she worked as a drug discovery project leader at Zealand Pharma but came back to continue as Associate Professor at Department of Biomedical Sciences.
Her research is focused on renal hemodynamics and hypertension. Changes in renal autoregulation and regulation as a consequence of changes in the topology of the renal vascular tree, intercellular communication and ion channel expression and function is investigated in different disease models. She is a member of American Physiological Society, Danish Hypertension Society and the Scandinavian Physiological Society. She lectures in renal physiology and cardiovascular and renal pharmacology and is responsible for the renal course and examination in renal physiology at 5th semester medical school. She is the co-author of the renal physiology book “Basal Nyrefysiologi” used at University of Copenhagen. She supervises bachelor, master and PhD students.
Primary fields of research
Our aim is to understand how the renal vasculature functions during normal conditions and during disease-states such as hypertension and diabetes. We investigate the mechanisms regulating the excretory function of the kidney. This includes control of renal blood flow (RBF), glomerular filtration rate (GFR) and the renin-angiotensin system. We focus on the structure of the vascular tree, intercellular communication via gap junctions, vascular regulation via ion channels, the sympathetic nervous system and changes in renal autoregulation.
Renal physiology, cardiovascular pharmacology, vascular physiology
Supervision: PhD, Master, Bachelor and research year students