Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

Research output: Contribution to journalJournal articlepeer-review

In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.
Original languageEnglish
JournalBritish Journal of Pharmacology
Volume159
Issue number5
Pages (from-to)1092-105
Number of pages14
ISSN0007-1188
DOIs
Publication statusPublished - Mar 2010

    Research areas

  • Binding, Competitive, Brain, Cell Line, Gene Expression, Humans, Kidney, Leukotrienes, Ligands, Myocardium, Protein Binding, Protein Isoforms, Receptors, G-Protein-Coupled, Reverse Transcriptase Polymerase Chain Reaction

ID: 48317125