Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
Research output: Contribution to journal › Journal article › peer-review
In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.
Original language | English |
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Journal | British Journal of Pharmacology |
Volume | 159 |
Issue number | 5 |
Pages (from-to) | 1092-105 |
Number of pages | 14 |
ISSN | 0007-1188 |
DOIs | |
Publication status | Published - Mar 2010 |
- Binding, Competitive, Brain, Cell Line, Gene Expression, Humans, Kidney, Leukotrienes, Ligands, Myocardium, Protein Binding, Protein Isoforms, Receptors, G-Protein-Coupled, Reverse Transcriptase Polymerase Chain Reaction
Research areas
ID: 48317125