Mette Rosenkilde
Professor
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2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17Research output: Contribution to journal › Journal article › Research › peer-review
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A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection
Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228Research output: Contribution to journal › Journal article › Research › peer-review
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A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus
Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659Research output: Contribution to journal › Journal article › Research › peer-review
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A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity
Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, Mette, Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor
Sun, W., Chen, L-N., Zhou, Q., Zhao, L-H., Yang, D., Zhang, H., Cong, Z., Shen, D-D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W. J. C., Zhao, S., Jiang, Y., Rosenkilde, M. M., Xu, H. E., Zhang, Y. & 1 others, , 2020, In: Cell Research. 30, 12, p. 1098-1108Research output: Contribution to journal › Journal article › Research › peer-review
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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI
Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute concomitant GIP receptor antagonism during GLP-1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity
Stensen, S., Krogh, L. L., wbf943, wbf943, Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 9, p. 1882-1887Research output: Contribution to journal › Journal article › Research › peer-review
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Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022
Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284Research output: Contribution to journal › Editorial › Research › peer-review
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Advances in incretin-based therapeutics for obesity
Rosenkilde, Mette, 2024, In: Nature Reviews Endocrinology. 20, p. 67–68 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74
Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach
Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial
Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro
Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, E., Xue, K., Giller, K., Becker, S., Mujezinovic, A., Bentzen, Bo Hjorth, Andreas, L. B., Kolocouris, A., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Communications Biology. 4, 10 p., 1347.Research output: Contribution to journal › Journal article › Research › peer-review
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Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms
Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Madsen, Thomas Daugbjerg, Hansen, L. H., Hintze, John, Ye, Z., Jebari, S., Andersen, Daniel Bjørklund, Joshi, Hiren Jitendra, Ju, T., Goetze, Jens P. , Martin, C., Rosenkilde, Mette, Holst, Jens Juul, Kuhre, Rune Ehrenreich, Goth, C. K., Vakhrushev, Sergey & Schjoldager, Katrine Ter-Borch Gram, 2020, In: Nature Communications. 11, 1, 13 p., 4033.Research output: Contribution to journal › Journal article › Research › peer-review
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Arrestin-independent constitutive endocytosis of GPR125/ADGRA3
Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199Research output: Contribution to journal › Journal article › Research › peer-review
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Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28
Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.Research output: Contribution to journal › Journal article › Research › peer-review
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Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21
Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196Research output: Contribution to journal › Journal article › Research › peer-review
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Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice
Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689Research output: Contribution to journal › Journal article › Research › peer-review
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Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2
Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042Research output: Contribution to journal › Journal article › Research › peer-review
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Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7
Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased and g protein-independent signaling of chemokine receptors
Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective
Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14Research output: Contribution to journal › Review › Research › peer-review
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5
Berg, Christian, Spiess, Katja, von Lüttichau, H. R. & Rosenkilde, Mette, Dec 2016, In: Pharmacology Research & Perspectives. 4, 6, 14 p., e00262.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection
Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466Research output: Contribution to journal › Journal article › Research › peer-review
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Chapter 8. Activation mechanisms of chemokine receptors
Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
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Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists
Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V
Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Constitutive and regulated activities of virus-encoded 7TM receptors
Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis
Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
Berg, Christian, Friis, M. B., Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Lüttichau, H. R. & Sundelin, T., 2019, In: PLoS ONE. 14, 9, 14 p., e0222053.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of potent and proteolytically stable human neuromedin U receptor agonists
De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential regulation of CXCR4 and CCR5 endocytosis
Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2
Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation
Fares, S., Spiess, Katja, Olesen, Emma Tina Bisgaard, Zuo, J., Jackson, S., Kledal, T. N., Wills, M. R. & Rosenkilde, Mette, 2019, In: mBio. 10, 1, e01707-18.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans
Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats
Pedersen, C., Bouman, S. D., Porsgaard, T., Rosenkilde, Mette & Roed, N. K., 2018, In: Physiological Reports. 6, 6, 9 p., e13657 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EBI2 in splenic and local immune responses and in autoimmunity
Barington, L., Wanke, F., Niss Arfelt, K., Holst, Peter Johannes, Kurschus, F. C. & Rosenkilde, Mette, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 313-322 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies
Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
Nørregaard, K., Benned-Jensen, T. & Rosenkilde, Mette, 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EBV, the Human Host, and the 7TM Receptors: Defense or Offense?
Arfelt, K. N., Fares, S. & Rosenkilde, Mette, 2015, The Molecular Basis of Viral Infection. Klasse, P. J. (ed.). Academic Press, Vol. 129. p. 395-427 (Progress in Molecular Biology and Translational Science, Vol. 129).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial
Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, Jacob, Jonsson, G., Aarøe, J., Gasbjerg, Lærke Smidt, Rosenkilde, Mette & Gögenur, Ismail, Dec 2017, In: Journal of Cardiovascular Translational Research. 10, 5-6, p. 470-479 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of endogenous GIP in patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes
Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in Beta Cell Function in Patients with Type 2 Diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: Diabetes. 71, 10, p. 2209-2221Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system
Gabe, M. B. N., van der Velden, W. J. C., Gadgaard, S., Smit, F. X., Hartmann, Bolette, Bräuner, Hans & Rosenkilde, Mette, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 122-132Research output: Contribution to journal › Journal article › Research › peer-review
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Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice
Gobron, B., Bouvard, B., Vyavahare, S., Blom, L. V. V., Pedersen, K. K., Windeløv, Johanne Agerlin, Boer, G. A., Harada, N., Zhang, S., Shimazu-Kuwahara, S., Wice, B., Inagaki, N., Legrand, E., Flatt, P. R., Chappard, D., Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette, Irwin, N. & Mabilleau, G., 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1363-1374 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor
Paulsen, S., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality
Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor
Paulsen, S. J., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action
de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.Research output: Contribution to journal › Review › Research › peer-review
- Published
Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin
Ribeiro, R. V. P., Ku, T., Wang, A., Pires, L., Ferreira, V. H., Michaelsen, V., Ali, A., Galasso, M., Moshkelgosha, S., Gazzalle, A., Jeppesen, Mads Gravers, Rosenkilde, Mette, Liu, M., Singer, L. G., Kumar, D., Keshavjee, S., Sinclair, J., Kledal, T. N., Humar, A. & Cypel, M., 2022, In: Journal of Heart and Lung Transplantation. 41, 3, p. 287-297Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.
Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5
Rummel, P. C., Thiele, S., Gasbjerg, Lærke Smidt, Petersen, T. P., wbf943, wbf943, Ulven, T. & Rosenkilde, Mette, 13 Jun 2013, In: Current Molecular Pharmacology. 84, 3, p. 335-345 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo
Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, Mette, Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors
Spiess, Katja & Rosenkilde, Mette, 2014, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Stevens, C. W. (ed.). Humana Press, p. 45-64 20 p. (Methods in Pharmacology and Toxicology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications
Goth, C. K., Petaja-Repo, U. E. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 237-245Research output: Contribution to journal › Review › Research › peer-review
- Published
G protein-coupled receptor pharmacology-The next generation
Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.Research output: Contribution to journal › Editorial › Research
- Published
GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e725-e738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells
Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2
Gasbjerg, Lærke Smidt, Hartmann, Bolette, Christensen, Mikkel Bring, Lanng, A. R., Vilsbøll, Tina, Jørgensen, Niklas Rye, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 130, 6 p., 115079 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Hartmann, Bolette, Lanng, A. R., wbf943, wbf943, Gabe, M. B. N., Dela, Flemming, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, Feb 2018, In: Diabetologia. 61, 2, p. 413-423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation
Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men
Skov-Jeppesen, Kirsa, Svane, M. S., Martinussen, C., Gabe, M. B. N., Gasbjerg, Lærke Smidt, Veedfald, Simon, Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2019, In: Bone. 125, p. 178-185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR119 as a fat sensor
Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR162 is a beta cell CART receptor
Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Bartlett, S., Gemiarto, A. T., Ngo, M. D., Sajiir, H., Hailu, S., Sinha, R., Foo, C. X., Kleynhans, L., Tshivhula, H., Webber, T., Bielefeldt-Ohmann, H., West, N. P., Hiemstra, A. M., MacDonald, C. E., Christensen, Liv von Voss, Schlesinger, L. S., Walzl, G., Rosenkilde, Mette, Mandrup-Poulsen, Thomas & Ronacher, K., 2020, In: Frontiers in Immunology. 11, 11 p., 601534.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection
Foo, C. X., Bartlett, S., Chew, K. Y., Ngo, M. D., Bielefeldt-Ohmann, H., Arachchige, B. J., Matthews, B., Reed, S., Wang, R., Smith, C., Sweet, M. J., Burr, L., Bisht, K., Shatunova, S., Sinclair, J. E., Parry, R., Yang, Y., Lévesque, J. P., Khromykh, A., Rosenkilde, M. M. & 2 others, , 2023, In: The European respiratory journal. 61, 3, 15 p., 2201306.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity
Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)
Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose and Amino Acid Metabolism in Mice Depend Mutually on Glucagon and Insulin Receptor Signaling
Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Rosenkilde, Mette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E660-E673Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes
Christensen, Mikkel Bring, Calanna, S., wbf943, wbf943, Kristensen, P. L., Rosenkilde, Mette, Faber, Jens, Purrello, F., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Jan 2015, In: Diabetes. 64, 1, p. 72-78 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes
Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
Gasbjerg, Lærke Smidt, Gabe, M. B. N., Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Feb 2018, In: Peptides. 100, p. 173-181Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice
Boer, G. A., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Sparre-Ulrich, A. H., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4486-4499Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
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