Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:

    ORCID: 0000-0001-9600-3254

    Publication year:
    All
    1 - 100 out of 270Page size: 100
    1. 1997
    2. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      How receptor mutagenesis may confirm or confuse receptor classification

      Schwartz, Thue W., Perlman, S., Rosenkilde, Mette & Hjorth, S. A., 1997, In: Annals of the New York Academy of Sciences. 817, p. 71-84

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4

      Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, Mette, Schwartz, Thue W., Luther, M. A., Wells, T. N. C., Hoxie, J. A. & March, M., 1997, In: Journal of Cell Biology. 139, no. 3, p. 651-664

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist

      Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, Mette, Schwartz, Thue W., Buser, R., Weels, T. N. C. & Proudfoot, A., 1997, In: Kexue (Shanghai). 276, p. 276-279

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 1998
    7. Published

      Differential regulation of CXCR4 and CCR5 endocytosis

      Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

      Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28

      Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies

      Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. 1999
    12. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

      Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2000
    15. Published

      Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor

      Rosenkilde, Mette & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 57, no. 3, p. 602-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74

      Rosenkilde, Mette, Kledal, T. N., Holst, Peter Johannes & Schwartz, Thue W., 2000, In: Journal of Biological Chemistry. 275, 34, p. 26309-15 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2001
    18. Published

      Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

      Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Virally encoded 7TM receptors

      Rosenkilde, Mette, Waldhoer, M., Lüttichau, H. R. & Schwartz, Thue W., 2001, In: Oncogene. 20, 13, p. 1582-93 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2003
    21. Published

      Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

      Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. 5, 2, p. 179-87 8 p.

      Research output: Contribution to journal › Review › Research

    23. Published

      Microbiological exploitation of the chemokine system

      Holst, Peter Johannes & Rosenkilde, Mette, 2003, In: Microbes and Infection. Vol. 2, p. 179-87

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

      Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Virally encoded chemokines and chemokine receptors in the role of viral infections

      Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. 2004
    29. Published

      A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

      Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, Mette, Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Constitutive and regulated activities of virus-encoded 7TM receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

      Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

    31. Published

      Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

      Heydorn, A., Ward, R. J., Jorgensen, R., Rosenkilde, Mette, Frimurer, T. M., Milligan, G. & Kostenis, E., 2004, In: Molecular Pharmacology. Vol. 66, no. 2, p. 250-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

      Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74

      McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins

      Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      The chemokine system - a major regulator of angiogenesis in health and disease

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. 2005
    40. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor

      Paulsen, S., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor

      Paulsen, S. J., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3

      Rosenkilde, Mette, Kledal, T. N. & Schwartz, Thue W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      High content screening for G protein-coupled receptors using cell-based protein translocation assays

      Grånäs, C., Lundholt, B. K., Heydorn, A., Linde, V., Pedersen, H., Krog-Jensen, C., Rosenkilde, Mette & Pagliaro, L., 2005, In: Combinatorial Chemistry & High Throughput Screening. 8, 4, p. 301-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Virus-encoded chemokine receptors - putative novel innovative drug targets

      Rosenkilde, Mette, 2005, In: Neuropharmacology. Vol. 48, no. 1, p. 1-13

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Virus-encoded chemokine receptors--putative novel antiviral drug targets

      Rosenkilde, Mette, 2005, In: Neuropharmacology. 48, 1, p. 1-13 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. 2006
    48. Published

      Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

      Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V

      Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

      Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Molecular mechanism of 7TM receptor activation--a global toggle switch model

      Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

      Rosenkilde, Mette, Benned-Jensen, T., Holst, Peter Johannes, Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, Jan Pravsgaard, Schwartz, Thue W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

      Ugleholdt, Randi Kjærsgaard, Poulsen, M. H., Holst, Peter Johannes, Irminger, J., Orskov, C., Pedersen, Jens, Rosenkilde, Mette, Zhu, X., Steiner, D. F. & Holst, Jens Juul, 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Targeting herpesvirus reliance of the chemokine system

      Rosenkilde, Mette & Kledal, T. N., 2006, In: Current Drug Targets. 7, 1, p. 103-18 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 2007
    58. Published

      Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

      Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo

      Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, Mette, Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3

      Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

      Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

      Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

      Rosenkilde, Mette, Gerlach, L., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 37, p. 27354-65 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects

      Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, Cathrine, Rosenkilde, Mette, Hartmann, B. & Holst, Jens Juul, 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. 2008
    66. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist

      Benned-Jensen, T. & Rosenkilde, Mette, 2008, In: Molecular Pharmacology. 74, 4, p. 1008-21 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors

      Rosenkilde, Mette, Smit, M. J. & Waldhoer, M., 2008, In: British Journal of Pharmacology. 153 Suppl 1, p. S154-66

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

      Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. 2009
    71. Published

      Chapter 8. Activation mechanisms of chemokine receptors

      Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Ligand binding and micro-switches in 7TM receptor structures

      Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      The role of transmembrane segment II in 7TM receptor activation

      Benned-Jensen, T. & Rosenkilde, Mette, Jun 2009, In: Current Molecular Pharmacology. 2, 2, p. 140-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. 2010
    75. Published

      Targeting CXCR4 in HIV Cell-Entry Inhibition

      Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      The minor binding pocket: a major player in 7TM receptor activation

      Rosenkilde, Mette, Benned-Jensen, T., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

      Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Treatment of insulin resistance and obesity by stimulating GLP-1 release

      Hansen, Harald S., Diep, T. A., Holst, Jens Juul, Rosenkilde, Mette & Andersen, N. W., 29 Dec 2010, IPC No. A61K 31/23, Patent No. PCT/DK2010/050161, 24 Jun 2010

      Research output: Patent

    79. 2011
    80. Published

      2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

      Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

      Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

      Nørregaard, K., Benned-Jensen, T. & Rosenkilde, Mette, 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

      Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, GIANT Consortium, G. C., 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2.

      Rummel, P. C., Thiele, S., Steen, A. M. F., Elder, A., Kolbech, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: British Journal of Pharmacology. 166

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

      Benned-Jensen, T., Mokrosinski, J. & Rosenkilde, Mette, 2011, In: P L o S One. 6, 9, p. e24644

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

      Farrell, H. E., Abraham, A. M., Cardin, R. D., wbf943, wbf943, Rosenkilde, Mette, Spiess, Katja, Jensen, T. H., Kledal, T. N. & Davis-Poynter, N., Jun 2011, In: Journal of Virology. 85, 12, p. 6091-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST

      Benned-Jensen, T., Smethurst, C., Holst, Peter Johannes, Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, Thue W., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

      Ugleholdt, Randi Kjærsgaard, Pedersen, Jens, Bassi, Maria Rosaria, Füchtbauer, E., Jørgensen, S. M., Kissow, Hannelouise, Nytofte, N., Poulsen, Steen Seier, Rosenkilde, Mette, Seino, Y., Thams, P., Holst, Peter Johannes & Holst, Jens Juul, Dec 2011, In: The Journal of Biological Chemistry. 286, 52, p. 44632-44645 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. 2012
    90. Published

      Molecular Pharmacology of CXCR4 inhibition

      Steen, A. & Rosenkilde, Mette, 2012, Novel Developments in Stem Cell Mobilization : Focus on CXCR4. Fruehauf, S., Zeller, J. W. & Calandra, G. (eds.). Springer Science+Business Media, p. 23-35

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    91. Published

      Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?

      Mølleskov-Jensen, A., wbf943, wbf943, Davis-Poynter, N. & Rosenkilde, Mette, 2012, In: Advances in Virology. 2012, p. 231813

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2

      Jensen, P. C., Thiele, S., Steen, A., Elder, A., Kolbeck, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, May 2012, In: British Journal of Pharmacology. 166, 1, p. 258-75 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      GPR119 as a fat sensor

      Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4)

      Mungalpara, J., Thiele, S., Eriksen, Ø., Eksteen, J., Rosenkilde, Mette & Våbenø, J., 9 Oct 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10287-10291 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

      Benned-Jensen, T., Norn, C., Laurent, S., Madsen, C. M., Larsen, H. M., Arfelt, K. N., Wolf, R. M., Frimurer, Thomas Michael, Sailer, A. W. & Rosenkilde, Mette, 12 Oct 2012, In: The Journal of Biological Chemistry. 287, 42, p. 35470-83 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions

      Rummel, P. C., Arfelt, K. N., Baumann, L., Jenkins, T. J., Thiele, S., Lüttichau, H. R., Johnsen, A., Pease, J., Ghosh, S., Kolbeck, R. & Rosenkilde, Mette, Nov 2012, In: British Journal of Pharmacology. 167, 6, p. 1206-17 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

      Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. 2013
    100. Published

      Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation

      Benned-Jensen, T., Madsen, C. M., Arfelt, K. N., Smethurts, C., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 2013, In: FEBS Open Bio. 3, p. 156-60 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Published

      Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

      Farrell, H. E., Abraham, A. M., Cardin, R. D., Mølleskov-Jensen, A., Rosenkilde, Mette & Davis-Poynter, N., Apr 2013, In: Journal of Virology. 87, 7, p. 4112-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    102. Published

      Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7

      Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5

      Rummel, P. C., Thiele, S., Gasbjerg, Lærke Smidt, Petersen, T. P., wbf943, wbf943, Ulven, T. & Rosenkilde, Mette, 13 Jun 2013, In: Current Molecular Pharmacology. 84, 3, p. 335-345 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands

      Petersen, T. P., Mirsharghi, S., Rummel, P. C., Thiele, S., Rosenkilde, Mette, Ritzén, A. & Ulven, Trond, 8 Jul 2013, In: Chemistry: A European Journal. 19, 28, p. 9343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

      Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists

      Mungalpara, J., Zachariassen, Z. G., Thiele, S., Rosenkilde, Mette & Våbenø, J., 21 Dec 2013, In: Organic & Biomolecular Chemistry. 11, 47, p. 8202-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. 2014
    108. Published

      Biased and g protein-independent signaling of chemokine receptors

      Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2

      Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. Published

      Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

      Spiess, Katja & Rosenkilde, Mette, 2014, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Stevens, C. W. (ed.). Humana Press, p. 45-64 20 p. (Methods in Pharmacology and Toxicology).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    111. Published

      Interaction of chemokines with their receptors--from initial chemokine binding to receptor activating steps

      Thiele, S. & Rosenkilde, Mette, 2014, In: Current Medicinal Chemistry. 21, 31, p. 3594-614 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. Published

      Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

      Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    113. Published

      Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor

      Gessier, F., Preuss, I., Yin, H., Rosenkilde, Mette, Laurent, S., Endres, R., Chen, Y. A., Marsilje, T. H., Seuwen, K., Nguyen, D. G. & Sailer, A. W., 24 Apr 2014, In: Journal of Medicinal Chemistry. 57, 8, p. 3358-68 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. Published

      Oxysterol-EBI2 signaling in immune regulation and viral infection

      Daugvilaite, V., Arfelt, K. N., Benned-Jensen, T., Sailer, A. W. & Rosenkilde, Mette, Jul 2014, In: European Journal of Immunology. 44, 7, p. 1904-12 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    115. Published

      Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

      Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    116. Published

      Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

      Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. 2015
    118. Published

      EBV, the Human Host, and the 7TM Receptors: Defense or Offense?

      Arfelt, K. N., Fares, S. & Rosenkilde, Mette, 2015, The Molecular Basis of Viral Infection. Klasse, P. J. (ed.). Academic Press, Vol. 129. p. 395-427 (Progress in Molecular Biology and Translational Science, Vol. 129).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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