Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

Research output: Contribution to journalJournal articleResearchpeer-review

The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland infection/replication and reduced efficiency of reactivation from tissue explants. M33-mediated G protein-coupled signaling is critical for the salivary gland phenotype. In this report, we demonstrate that US28 and (to a lesser degree) UL33 restore reactivation from tissue explants and partially restore replication in salivary glands (compared to a signaling-deficient M33 mutant). These studies provide a novel small animal model for evaluation of therapies targeting the human CMV CKRs.

Original languageEnglish
JournalJournal of Virology
Issue number12
Pages (from-to)6091-5
Number of pages5
Publication statusPublished - Jun 2011

    Research areas

  • Animals, Cytomegalovirus, Cytomegalovirus Infections, Disease Models, Animal, Female, Herpesviridae Infections, Humans, Mice, Mice, Inbred BALB C, Muromegalovirus, Organ Specificity, Receptors, Chemokine, Salivary Glands, Viral Proteins, Virus Activation, Virus Latency, Virus Replication

ID: 137987172