Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2
Research output: Contribution to journal › Journal article › peer-review
The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe a novel piperidine-based compound with structural similarity to previously described CCR8-specific agonists, but containing a unique phenyl-tetrazol moiety which, in addition to activity at CCR8 was also active at CCR1.
| Original language | English |
|---|---|
| Journal | British Journal of Pharmacology |
| Volume | 166 |
| Issue number | 1 |
| Pages (from-to) | 258-75 |
| Number of pages | 18 |
| ISSN | 0007-1188 |
| DOIs | |
| Publication status | Published - May 2012 |
- Animals, Binding Sites, COS Cells, Cercopithecus aethiops, Glutamic Acid, Humans, Inositol 1,4,5-Trisphosphate, Ligands, Models, Molecular, Piperidines, Point Mutation, Receptors, CCR1, Receptors, CCR8, Tetrazoles
Research areas
ID: 48972161