Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions
Research output: Contribution to journal › Journal article › peer-review
Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.
| Original language | English |
|---|---|
| Journal | British Journal of Pharmacology |
| Volume | 167 |
| Issue number | 6 |
| Pages (from-to) | 1206-17 |
| Number of pages | 12 |
| ISSN | 0007-1188 |
| DOIs | |
| Publication status | Published - Nov 2012 |
- Animals, Binding Sites, Binding, Competitive, COS Cells, Cercopithecus aethiops, Chemokine CCL1, Chemokines, CC, Ligands, Naphthalenes, Receptors, CCR8, Viral Proteins
Research areas
ID: 47965272