Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions
Research output: Contribution to journal › Journal article › peer-review
Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition requires alternative structural probes.
|Journal||British Journal of Pharmacology|
|Number of pages||12|
|Publication status||Published - Nov 2012|
- Animals, Binding Sites, Binding, Competitive, COS Cells, Cercopithecus aethiops, Chemokine CCL1, Chemokines, CC, Ligands, Naphthalenes, Receptors, CCR8, Viral Proteins