Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

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    1. Published

      Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

      Ullitz Thorsen, S., Liu, X., Kataria, Y., Mandrup-poulsen, T., Kaur, S., Uusitalo, U., Virtanen, S. M., Norris, J., Rewers, M., Hagopian, W., Yang, J., She, J., Akolkar, B., Rich, S. S., Aronsson, C. A., Lernmark, Å., Ziegler, A., Toppari, J., Krischer, J. P., Parikh, H. M. & 31 others, Ellervik, Christina, Svensson, Jannet, Rewers, M., Barbour, A., Bautista, K., Baxter, J., Felipe-morales, D., Frohnert, B. I., Stahl, M., Gesualdo, P., Hoffman, M., Karban, R., Liu, E., Munoz, A., Norris, J., O’donnell, H., Peacock, S., Shorrosh, H., Steck, A., Stern, M., Waugh, K., Toppari, J., Simell, O. G., Adamsson, A., Ahonen, S., Åkerlund, M., Anttila, S., Hakola, L., Hekkala, A., Agardh, D. & Environmental Determinants of Diabetes in the Young (TEDDY) Group, E. D. O. D. I. T. Y. (. G., 2023, In: Diabetes Care. 46, 5, p. 1-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

      Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

      Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes. 63, 6, p. 1833-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

      Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B. & 12 others, Badenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, Hans, Mandrup-Poulsen, Thomas & Type 1 Diabetes TrialNet Canakinumab Study Group, T. 1. D. T. C. S. G., 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-15 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

      Cabrera, S. M., Wang, X., Chen, Y., Jia, S., Kaldunski, M. L., Greenbaum, C. J., Mandrup-Poulsen, Thomas & Hessner, M. J., Apr 2016, In: European Journal of Immunology. 46, 4, p. 1030-1046 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes

      Mandrup-Poulsen, Thomas, 2012, In: The review of diabetic studies : RDS. 9, 4, p. 338-47 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Interleukin-1 antagonists for diabetes

      Mandrup-Poulsen, Thomas & AIDA study group, A. S. G., Aug 2013, In: Expert Opinion on Investigational Drugs. 22, 8, p. 965-79 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine

      Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Interleukin-1 receptorantagonistbehandling af patienter med type 2-diabetes--sekundaerpublikation.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M., 2007, In: Ugeskrift for læger. 169, 45, p. 3868-71 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus - Reply

      Mandrup-Poulsen, Thomas, Seifert, B. & Donath, M. Y., 2007, In: New England Journal of Medicine. 357, 3, p. 303-303

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M. Y., 2007, In: New England Journal of Medicine. 356, 15, p. 1517-26 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

      Ballak, D. B., Li, S., Cavalli, G., Stahl, J. L., Tengesdal, I. W., van Diepen, J. A., Kluck, V., Swartzwelter, B., Azam, T., Tack, C. J., Stienstra, R., Mandrup-Poulsen, Thomas, Seals, D. R. & Dinarello, C. A., 2018, In: Journal of Biological Chemistry. 293, 37, p. 14224-14236

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Interleukin-6 and diabetes: the good, the bad, or the indifferent?

      Kristiansen, O. P. & Mandrup-Poulsen, Thomas, 2005, In: Diabetes. 54 Suppl 2, p. S114-24

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Interleukin-6 receptor blockade or TNF alpha inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials

      Genovese, M. C., Burmester, G. R., Hagino, O., Thangavelu, K., Iglesias-Rodriguez, M., John, G. S., Gonzalez-Gay, M. A., Mandrup-Poulsen, Thomas & Fleischmann, R., 2020, In: Arthritis Research & Therapy. 22, 1, 12 p., 206.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Iron: the hard player in diabetes pathophysiology

      Hansen, J. B., Moen, I. W. & Mandrup-Poulsen, Thomas, Apr 2014, In: Acta Physiologica (Print). 210, 4, p. 717-32 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

      Backe, M. B., Moen, I. W., Ellervik, Christina, Hansen, J. B. & Mandrup-Poulsen, Thomas, 17 Jul 2016, In: Annual Review of Nutrition. 36, p. 241-273 33 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Iron Status and Gestational Diabetes: A Meta-Analysis

      Kataria, Y., Wu, Y., Horskjaer, P. D. H., Mandrup-Poulsen, Thomas & Ellervik, Christina, 2018, In: Nutrients. 10, 5, 15 p., 621 .

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

      Gillespie, K. M., Nolsøe, R., Betin, V. M., Kristiansen, O. P., Bingley, P. J., Mandrup-Poulsen, Thomas & Gale, E. A. M., 2005, In: Diabetes. 54, 4, p. 1245-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics

      Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression

      Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Størling, Joachim & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

      Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial

      Hadley, D., Cheung, R. K., Becker, D. J., Girgis, R., Palmer, J. P., Cuthbertson, D., Krischer, J. P., Dosch, H., TRIGR North America Investigators, T. N. A. I. & Mandrup-Poulsen, Thomas, Feb 2014, In: Clinical and Vaccine Immunology (Online). 21, 2, p. 203-11 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients

      Østergaard, H. B., Mandrup-Poulsen, Thomas, Berkelmans, G. F. N., van der Graaf, Y., Visseren, F. L. J. & Westerink, J., 2019, In: Diabetes and Metabolism. 45, 3, p. 254-260 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Lost in translation

      Frank, L. & Mandrup-Poulsen, Thomas, 2007, In: Weekendavisen. 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

      Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, Thomas, 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

      Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

      Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, Michael, Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, Thomas, 15 Jan 2018, In: Molecular and Cellular Endocrinology. 460, p. 47-56 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

      Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

      Vestergaard, A. L., Bang-Berthelsen, C. H., Floyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., Horskjaer, P. D. H., Frederiksen, K. S., Kofod, F. G., Bruun, C., Berchtold, L. A., Storling, J., Regazzi, R., Kaur, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 27 Sep 2018, In: PLOS ONE. 13, 9, p. 1-22 22 p., e0203713 .

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      MicroRNAs are potential posttranscriptional regulators of Bcl-2 family members after cytokine stimulation in INS-1 cells

      Bang-Berthelsen, C. H., Grunnet, L. G., Kutlu, B., Johansson, F., Eizirik, D., Pociot, F. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1, p. 152-152

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      MicroRNAs as regulators of beta-cell function and dysfunction

      Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Mitophagy protects beta cells from inflammatory damage in diabetes

      Sidarala, V., Pearson, G. L., Parekh, V. S., Thompson, B., Christen, L., Gingerich, M. A., Zhu, J., Stromer, T., Ren, J., Reck, E. C., Chai, B., Corbett, J. A., Mandrup-Poulsen, Thomas, Satin, L. S. & Soleimanpour, S. A., 2020, In: JCI insight. 5, 24, 15 p., 141138.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.

      Greenbaum, C. J., Mandrup-Poulsen, Thomas, McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., Pozzilli, P., Lachin, J. M., Kolb, H., Type 1 Diabetes Trial Net Research Group, T. 1. D. T. N. R. G. & European C-Peptide Trial Study Group, E. C. T. S. G., 2008, In: Diabetes Care. 31, 10, p. 1966-71 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes

      Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Need for Reclassification of Diabetes Secondary to Iron Overload in the ADA and WHO Classifications

      Ellervik, Christina, Birgens, H. & Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes Care. 37, 6, p. e137-e138 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Neuromedin U Does Not Act as a Decretin in Rats

      Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

      Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      No direct effect of SGLT2 activity on glucagon secretion

      Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

      Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    41. Published

      Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

      Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2014.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    42. Published

      Obesity-induced changes in gene expression in feline adipose and skeletal muscle tissue

      Jensen, Kathrine Stenberg, Novotny, G. W., Lutz, T. A., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2023, In: Journal of Animal Physiology and Animal Nutrition. 107, 5, p. 1262 - 1278

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice

      Besançon, A., Goncalves, T., Valette, F., Dahllöf, M. S., Mandrup-Poulsen, Thomas, Chatenoud, L. & You, S., 1 Feb 2018, In: Diabetologia. 61, 2, p. 389-398 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

      Brandt, C., Hansen, R. H., Hansen, J. B., Olsen, C. H., Galle, P., Mandrup-Poulsen, Thomas, Gehl, Julie, Pedersen, Bente Klarlund & Hojman, P., Feb 2015, In: Metabolism. 64, 2, p. 283-295 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Pancreatic beta-cells respond to fuel pressure with an early metabolic switch

      Malinowski, R. M., Ghiasi, S. M., Mandrup-Poulsen, Thomas, Meier, S., Lerche, M. H., Ardenkjaer-Larsen, J. H. & Jensen, P. R., 2020, In: Scientific Reports. 10, 1, 11 p., 15413.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Perspective: Testing failures

      Mandrup-Poulsen, Thomas, 2012, In: Nature Study. 485, 7398, p. S17

      Research output: Contribution to journal › Journal article › Commissioned

    47. Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

      Grunnet, Louise Groth, Poulsen, P., Pedersen, Bente Klarlund, Mandrup-Poulsen, Thomas & Vaag, A., 1 Feb 2006, In: Diabetologia. 49, 2, p. 343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Poor pregnancy outcome in women with type 2 diabetes

      Clausen, Tine Dalsgaard, Mathiesen, E., Ekbom, P., Hellmuth, E., Mandrup-Poulsen, Thomas & Damm, Peter, 2005, In: Diabetes Care. 28, 2, p. 323-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Proinflammatory Cytokines Inhibit TIMP-1 Expression but Induces PAI-1 and CD63 Expression in INS-1 Cells

      Hansen, J. B., Brunner, N. & Mandrup-Poulsen, Thomas, 2009.

      Research output: Contribution to conference › Poster › Research

    50. Published

      Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

      Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity

      Andersen, Phillip Alexander Keller, Petrenko, V., Rose, P. H., Koomen, M., Fischer, N., Ghiasi, S. M., Dahlby, T., Dibner, C. & Mandrup-Poulsen, Thomas, 2021, In: International Journal of Molecular Sciences. 22, 1, p. 1-25 83.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

      Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, Jens Høiriis, Porse, Bo Torben, Mandrup-Poulsen, Thomas & Rutter, G. A., 2024, In: Frontiers in Endocrinology. 15, 13 p., 1359147.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Proliferation of sorted human and rat beta cells

      Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Protection against inflammatory β-cell damage by lysine deacetylase inhibition and microRNA expression?

      Vestergaard, A. L., Pallesen, E. M. H., Novotny, G. W., Noesgaard, D., Lundh, M., Regazzi, R. & Mandrup-Poulsen, Thomas, 15 Sep 2015. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    55. Published

      RNA modifications by oxidation: a novel disease mechanism?

      Poulsen, Henrik Enghusen, Specht, E., Broedbaek, K., Henriksen, T., Ellervik, Christina, Mandrup-Poulsen, Thomas, Tonnesen, M., Nielsen, Peter E., Andersen, H. U. & Weimann, A., Apr 2012, In: Free Radical Biology & Medicine. 52, 8, p. 1353-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.

      Zaitseva, I. I., Sharoyko, V., Størling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, Thomas, Nicotera, P., Berggren, P. & Zaitsev, S. V., 2006, In: Biochemical and Biophysical Research Communications. 347, 4, p. 1121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Recruitment and retention of participants for an international type 1 diabetes prevention trial: a coordinators' perspective

      Franciscus, M., Nucci, A., Bradley, B., Suomalainen, H., Greenberg, E., Laforte, D., Kleemola, P., Hyytinen, M., Salonen, M., Martin, M. J., Catte, D., Catteau, J., TRIGR Investigators, T. I. & Mandrup-Poulsen, Thomas, Apr 2014, In: Clinical Trials. 11, 2, p. 150-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis

      Ghiasi, S. M., Dahllöf, M. S., Osmai, Y., Osmai, M., Jakobsen, K. K., Aivazidis, A., Tyrberg, B., Perruzza, L., Prause, Michala Cecilie Burstein, Christensen, D. P., Fog-Tonnesen, M., Lundh, M., Grassi, F., Chatenoud, L. & Mandrup-Poulsen, Thomas, 2018, In: Molecular and Cellular Endocrinology. 478, p. 106-114

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256-2258

      Ellervik, Christina, Mandrup-Poulsen, Thomas, Birgens, H. & Nordestgaard, Børge, 2012, In: Diabetes Care. 35, 6, p. e48

      Research output: Contribution to journal › Journal article › Research

    60. Published

      Role of IL-1beta in type 2 diabetes

      Dinarello, C. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 1 Aug 2010, In: Current Opinion in Endocrinology, Diabetes and Obesity. 17, 4, p. 314-21 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case–control ancillary study

      Miettinen, M. E., Niinistö, S., Erlund, I., Cuthbertson, D., Nucci, A. M., Honkanen, J., Vaarala, O., Hyöty, H., Krischer, J. P., Knip, M., Virtanen, S. M., Mandrup-Poulsen, Thomas & TRIGR Investigators, T. I., 2020, In: Diabetologia. 63, 4, p. 780-787 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

      Pham, M. N., Kolb, H., Mandrup-Poulsen, Thomas, Battelino, T., Ludvigsson, J., Pozzilli, P., Roden, M., Schloot, N. C. & European C-Peptide Trial, E. C. T., Feb 2013, In: Diabetes - Metabolism: Research and Reviews (Online). 29, 2, p. 166-70 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

      Bartels, Emil Daniel, Ploug, Thorkil, Størling, Joachim, Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 4, p. 351-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Skeletal muscle to pancreatic β-cell cross-talk: the effect of humoral mediators liberated by muscle contraction and acute exercise on β-cell apoptosis

      Christensen, C. S., P. Christensen, D., Lundh, M., Dahllöf, M. S., Haase, T. N., Velasquez, J. M., Laye, M. J., Mandrup-Poulsen, Thomas & Solomon, T. P. J., Oct 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. E1289-E1298 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Small-molecule inhibition of inflammatory β-cell death

      Lundh, M., Scully, S. S., Mandrup-Poulsen, Thomas & Wagner, B. K., Sep 2013, In: Diabetes, Obesity and Metabolism Online. 15 , 3, p. 176-84 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.

      Frobøse, H., Rønn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, Thomas & Billestrup, N., 2006, In: Molecular Endocrinology. 20, 7, p. 1587-96 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

      Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

      Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

      Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Ehses, J. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes Care. 32, 9, p. 1663-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

      Ablamunits, V., Henegariu, O., Hansen, J. B., Opare-Addo, L., Preston-Hurlburt, P., Santamaria, P., Mandrup-Poulsen, Thomas & Herold, K. C., 2012, In: Diabetes. 61, 1, p. 145-54 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

      Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Targeting innate immune mediators in type 1 and type 2 diabetes

      Donath, M. Y., Dinarello, C. A. & Mandrup-Poulsen, Thomas, 2019, In: Nature Reviews. Immunology. 19, 12, p. 734-746

      Research output: Contribution to journal › Review › Research › peer-review

    74. Published

      The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

      Ghiasi, S. M., Hansen, J. B., Christensen, D. P., Tyrberg, B. & Mandrup-Poulsen, Thomas, 2020, In: International Journal of Molecular Sciences (Online). 21, 12, 15 p., 4311.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      The Faroese, a genetic isolate with a strong founder effect, allows the identification of Type 1 diabetes susceptibility regions

      Nolsoe, R., Roin, J., Deckert, M., Bergholdt, R., Kelly, J., Brorsson, C., Harley, J., Olsen, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2008, In: Clinical Immunology. 127, Suppl. S, p. S105-S105

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Published

      The Fas pathway is involved in pancreatic beta cell secretory function.

      Schumann, D. M., Maedler, K., Franklin, I., Konrad, D., Størling, J., Böni-Schnetzler, M., Gjinovci, A., Kurrer, M. O., Gauthier, B. R., Bosco, D., Andres, A., Berney, T., Greter, M., Becher, B., Chervonsky, A. V., Halban, P. A., Mandrup-Poulsen, Thomas, Wollheim, C. B. & Donath, M. Y., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 8, p. 2861-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Published

      The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

      Backe, M. B., Jin, C., Andreone, L., Sankar, A., Agger, K., Helin, K., Madsen, A. N., Poulsen, Steen Seier, Bysani, M., Bacos, K., Ling, C., Javier Perone, M., Holst, Birgitte & Mandrup-Poulsen, Thomas, 2019, In: Journal of Diabetes Research. 2019, 15 p., 5451038.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

      Ghiasi, S. M., Krogh, Nicolai, Tyrberg, B. & Mandrup-Poulsen, Thomas, 2018, In: Diabetes. 67, 10, p. 2019-2037 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up

      Akerblom, H. K., Krischer, J., Virtanen, V. S., Berseth, C., Becker, D., Dupré, J., Ilonen, J., Trucco, M., Savilahti, E., Koski, K., Pajakkala, E., Fransiscus, M., Lough, G., Bradley, B., Koski, M., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 1 Mar 2011, In: Diabetologica. 54, 3, p. 627-633 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      The anti-interleukin-1 in type 1 diabetes action trial - Background and rationale

      Pickersgill, L. M. S. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 25, 4, p. 321-324 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration

      Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

      Kolb, H. & Mandrup-Poulsen, Thomas, 2009, In: Diabetologia. 53, 1, p. 10-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

      Zaitseva, I. I., Storling, J., Mandrup-Poulsen, Thomas, Berggren, P. O. & Zaitsev, S. V., 2008, In: Cellular and Molecular Life Sciences. 65, 7-8, p. 1248-1255 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

      Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      The inducible beta 5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets

      Khilji, Muhammad Saad, Bresson, S. E., Verstappen, D., Pihl, Celina, Andersen, Phillip Alexander Keller, Agergaard, Jette Bach, Dahlby, T., Holgersen Bryde, Tenna, Klindt, K., Nielsen, C. K., Walentinsson, A., Zivkovic, D., Bousquet, M., Tyrberg, B., Richardson, S. J., Morgan, N. G., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 318, 6, p. E892-E900

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

      Khilji, Muhammad Saad, Verstappen, D., Dahlby, T., Prause, Michala Cecilie Burstein, Pihl, Celina, Bresson, S. E., Holgersen Bryde, Tenna, Andersen, Phillip Alexander Keller, Klindt, K., Zivkovic, D., Bousquet-Dubouch, M. P., Tyrberg, B., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: PLoS ONE. 15, 2, 21 p., e0222432.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      The lysine deacetylase inhibitor givinostat inhibits ß-cell IL-1ß induced IL-1ß transcription and processing

      Dahllöf, M. S., Christensen, D. P., Lundh, M., Dinarello, C. A., Mascagni, P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Nov 2012, In: Islets. 4, 6, p. 417-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro

      Lewis, E. C., Blaabjerg, L., Størling, Joachim, Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, Thomas, May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      The role of NCAM signaling in the pancreatic beta-cell

      Grunnet, L. G., Storling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      The role of RNA oxidation in islet dysfunction in Type 2 diabetes

      Sileikaite, I., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1 , p. S37-S38

      Research output: Contribution to journal › Conference abstract in journal › Research

    91. Published

      The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.

      Donath, M. Y. & Mandrup-Poulsen, Thomas, 2008, In: Nature Clinical Practice Endocrinology & Metabolism. 4, 5, p. 240-1 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

      Engholm-Keller, K., Birck, P., Størling, Joachim, Pociot, Flemming, Mandrup-Poulsen, Thomas & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice

      Fjære, E., Andersen, C., Myrmel, L. S., Petersen, R. K., Hansen, J. B., Tastesen, H. S., Mandrup-Poulsen, Thomas, Brünner, N., Kristiansen, Karsten, Madsen, L. & Rømer, M. U. K., 2015, In: PloS one. 10, 7, 19 p., e0132910.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes - two general population studies

      Ellervik, Christina, Mandrup-Poulsen, Thomas, Tybjærg-Hansen, Anne & Nordestgaard, Børge, 15 Oct 2013, In: Diabetes Care. 37, 2, p. 444-452 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Total mortality by elevated transferrin saturation in patients with diabetes

      Ellervik, Christina, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M. M., Birgens, H., Nordestgaard, Børge & Mandrup-Poulsen, Thomas, Sep 2013, In: Diabetes Care. 36, 9, p. 2646-54 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Transcriptional and translational regulation of cytokine signaling in inflammatory ß-cell dysfunction and apoptosis

      Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. & Mandrup-Poulsen, Thomas, 2012, In: Archives of Biochemistry and Biophysics. 528, 2, p. 171-84

      Research output: Contribution to journal › Review › Research › peer-review

    97. Published

      Transplantation mellem enaeggede tvillinger

      Mandrup-Poulsen, Thomas, 26 Jan 2004, In: Ugeskrift for Laeger. 166, 5, p. 398-9; author reply 399

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

      Kataria, Y., Ellervik, Christina & Mandrup-Poulsen, Thomas, 2019, In: Seminars in Immunopathology. 41, 4, p. 413-425

      Research output: Contribution to journal › Review › Research › peer-review

    99. Published

      Type 1 database mellitus: an inflammatory disease of the islet.

      Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Type 1 diabetes - the copenhagen model

      Mandrup-Poulsen, Thomas, Binder, C., Deckert, T. & Nerup, J., 2007, Diabetes og Danmark. 1 ed. Gad, p. 184-195 11 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

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