Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
Research output: Contribution to journal › Journal article › Research › peer-review
The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 47 |
| Issue number | 11 |
| Pages (from-to) | 1998-2011 |
| Number of pages | 14 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - 1 Nov 2004 |
- Animals, Apoptosis, Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Interleukin-1, NF-kappa B, Nitric Oxide, Oligonucleotide Array Sequence Analysis, Rats, Repressor Proteins, Signal Transduction, Suppressor of Cytokine Signaling Proteins, Transcription Factors
Research areas
ID: 33902540