Inflammation, Metabolism and Oxidation
Blegdamsvej 3, 2200 København N, 12.6, Building: 08
Michal Marzec graduated as MD from the Medical University of Warsaw in 2000 and took his PhD in 2011 from the University of Bialystok. He was a visiting scholar and later Research Associate at the Department of Pathology and Laboratory Medicine at the University of Pennsylvania, USA (2001-2010).
He subsequently moved to the Abramson Pediatric Research Centre, Children’s Hospital, Pennsylvania, where within his 5 year NIH K01 grant he investigated the role of endoplasmic reticulum chaperones and their human variants in the context of hormone production.
Dr. Marzec has published 31 scientific publications of which 30 are original papers in high impact peer-reviewed international journals including PNAS, Blood, Oncogene, Cancer Res, J Immunol and J Biol Chem, 1 as a senior author, 11 as 1st author. He has an H-index of 21; total citations: 1950; citations since 2014: 1000.
During his stay in USA, he designed projects independently and actively helped in writing grants. He took an active part in teaching and advising students. Dr. Marzec has lectured regularly in the USA on his research, and is a regular reviewer for the top journals in his field (Blood, Lab Invest, Leukaemia, Oncogene).
Primary fields of research
Over the years, Michal's research interest has shifted from understanding oncogenic pathways to providing answers to why and how organisms differ in their susceptibility to diseases. Recent massive sequencing of thousands of individuals made it possible to study the impact of human variations on pathological processes underlying multiple diseases. He joined prof. Argon’s laboratory, to work on the involvement of GRP94 in the maturation and secretion of IGF molecules. Subsequently, he described the first human variant of GRP94 and its role in the pathogenesis of Primary IGF Deficiency.
Currently he is applying his expertise into diabetes pathology where he is investigating the role of endoplasmic reticulum chaperones in proinsulin folding. In addition he is exploring the possible link between population genetic variability of protein chaperones and the susceptibility to diabetes.