Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection
Research output: Contribution to journal › Journal article › Research › peer-review
The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 51 |
| Issue number | 10 |
| Pages (from-to) | 1873-1882 |
| Number of pages | 10 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - 2008 |
- Alloxan, Animals, Animals, Newborn, Apoptosis, Blotting, Western, Cytokines, Diabetes Mellitus, Experimental, Graft Survival, Humans, In Situ Nick-End Labeling, Islets of Langerhans, Islets of Langerhans Transplantation, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Transgenic, Rats, Reverse Transcriptase Polymerase Chain Reaction, Suppressor of Cytokine Signaling Proteins, Transplantation, Homologous
Research areas
ID: 9618268