Julien Ochala
Associate Professor - Promotion Programme
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NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
Ranu, N., Laitila, J., Dugdale, H. F., Mariano, J., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Fiorillo, C., Zanoteli, E., Auranen, M., Jokela, M., Tasca, G., Claeys, K. G., Voermans, N. C., Palmio, J., Huovinen, S., Moggio, M., Beck, T. N. & 3 others, , 2022, In: Acta Neuropathologica Communications. 10, 185.Research output: Contribution to journal › Journal article › Research › peer-review
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A Laing distal myopathy-associated proline substitution in the β-myosin rod perturbs myosin cross-bridging activity
Buvoli, M., Wilson, G. C., Buvoli, A., Gugel, J. F., Hau, A., Bönnemann, C. G., Paradas, C., Ryba, D. M., Woulfe, K. C., Walker, L. A., Buvoli, T., Ochala, Julien & Leinwand, L. A., 2024, In: The Journal of Clinical Investigation. 134, 9, 16 p., :e172599.Research output: Contribution to journal › Journal article › Research › peer-review
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A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation
Ochala, Julien, Iwamoto, H., Larsson, L. & Yagi, N., 25 May 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9807-12 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A myopathy-related actin mutation increases contractile function
Lindqvist, J., Pénisson-Besnier, I., Iwamoto, H., Li, M., Yagi, N. & Ochala, Julien, May 2012, In: Acta Neuropathologica. 123, 5, p. 739-746 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A rational approach to selective targeting of skeletal myosin
Katarina Antonovic, A., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 3S1, p. 117aResearch output: Contribution to journal › Journal article › Research › peer-review
Aberrant post-translational modifications compromise human myosin motor function in old age
Li, M., Ogilvie, H., Ochala, Julien, Artemenko, K., Iwamoto, H., Yagi, N., Bergquist, J. & Larsson, L., Apr 2015, In: Aging Cell. 14, 2, p. 228-35 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Abnormal myosin post-translational modifications and ATP turnover time associated with human congenital myopathy-related RYR1 mutations
Sonne, A., Antonovic, A. K., Thomsen, Elise Julie Melhedegaard, Akter, F., Andersen, J. L., Jungbluth, H., Witting, N., Vissing, John, Zanoteli, E., Fornili, A. & Ochala, Julien, 2023, In: Acta Physiologica. 239, 2, 14 p., e14035.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity
Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, Julien & Tsai, S. Y., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, p. 198–213Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding pocket dynamics along the recovery stroke of human β-cardiac myosin
Akter, F., Ochala, Julien & Fornili, A., 2023, In: PLOS Computational Biology. 19, 5, 14 p., e1011099.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?
Ochala, Julien, Feb 2010, In: Neuromuscular Disorders. 20, 2, p. 98-101 4 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 240294914
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104
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Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
Research output: Contribution to journal › Journal article › Research › peer-review
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59
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Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, myh1e321g
Research output: Contribution to journal › Journal article › Research › peer-review
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29
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Using nuclear envelope mutations to explore age-related skeletal muscle weakness
Research output: Contribution to journal › Journal article › Research › peer-review
Published