Larsen Group - Mitochondrial Physiology
The Larsen group focus primarily on human integrative physiology in health and disease. Our main interest is on mitochondrial physiology and how this is affected with disease and by exercise training. We are looking at the whole body down to the mitochondria.
We are focusing on the understanding of how mitochondrial function is affected by different intervention, such as exercise or diet supplementation. We are also interested in understanding how different drugs are affecting metabolism and mitochondrial function. Furthermore, we are also looking into how ageing affects the mitochondria. This research is conducted in human subjects, where we are going from whole body physiology to mitochondria physiology.
The specific goals of our research program are to:
- Understand how physical activity affects metabolism and mitochondrial function and metabolism (substrate oxidation), to better understand the discrepancy between subjects in regard to a training adaptation. This will potentially lead to more personalized training programs.
- Understand how different weight loss drugs affects metabolism and mitochondrial function.
- Understand how different diet supplementations affect metabolism and mitochondrial function.
Whole body phenotyping:
- Dual-Energy X-ray Absorptiometry (DEXA scan)
- Basal metabolic rate (BMR)
- Maximal oxygen uptake (bike or treadmill)
- High resolution respirometry and fluorometry (oroboros.at)
- Respiration, H2O2 emission, mitochondrial membrane potential, calcium cycling
- Enzyme activity
- Protein content
The mitochondrial analysis are done in skeletal muscle, adipose tissue and liver samples from humans, but we are also running these analysis in different animal models where other tissues are investigated.
- How weight loss drugs affects mitochondrial function
- Exercise intervention in patients with type 2 diabetes
- The effect of Coenzyme Q10 supplementation on different aging markers
- Is exercise and statins a good combination
- Team Danmark
- Innovations Fonden
- Nordea Fonden
|Anne-Sofie Lindblad Nissen
|Emma Bundgård Fals
|Frederik Kristoffer Winther Furbo