Exercise, metabolism and muscle in Xlab
Research focus
We focus on Human Integrative Physiology in Health and Disease. We make every effort to understand the metabolic and muscle remodelling behind exercise training, physical activity and diseases- from the whole body across organs, tissues, and cells to the intracellular environment.
We specifically study:
- Metabolic, cardiovascular and muscle regulations
- The whole body: across regions and organs, tissue and cells
- The morphology, integrity and function of organelles and muscle fibres
- The molecular signalling pathways and metabolic processes
- The intracellular compartmentalization as regulators of metabolic pathways
- The proteins (expression, location, functionality and abundance) in a systems biology approach.
We use:
- State of the art techniques in metabolic, muscle & cardiovascular research, as well as biochemical, immunochemical, biophysical and molecular biology analyses.
We focus on:
- Human physiology/pathophysiology and carry out advanced phenotyping in healthy subjects and patients, young and old
- Developing new methods to use high resolution light microscopy as a research tool in human physiology.
We collaborate with:
- Clinical research groups to study human liver, heart, skeletal muscle and/or visceral adipose tissue obtained in clinical trials
- Research groups that utilize animal experimental models, including horses, pigs, rats and mice
- Life Sciences industry.
Our research focuses on five main areas:
- Training and physical activity
- Mitochondrial physiology
- Compartmentalized Metabolism
- Muscle physiology
- Physical activity and Health: Exercise is Medicine
Training and physical activity
This research area overall focuses on training, fat oxidation, metabolic fitness and biological age:
- The effect of muscle lipids and particularly the bioactive lipid species diacylglycerol and ceramide influence on insulin sensitivity in humans.
- The effect of training and physical activity/inactivity on fat metabolism, metabolic fitness and flexibility.
- The mechanisms regulating muscle adaptation to training and/or inactivity and the effects of age and sex.
- Lifestyle intervention and maintenance of positive lifestyle changes.
- The effects of extreme long term endurance exercise in man and the influence of age.
- The application and measurement biological age in the lab and in real world.
If you would like more information, please contact Jørn Wulff Helge, jhelge@sund.ku.dk.
Mitochondrial physiology
Within this research area, we perform high quality measures of the mitochondrial functionality. Our primary measures are respiratory analysis, measures of free radicals production and of the inner mitochondrial membrane potential. Furthermore, we measure several different mitochondrial related enzymes, proteins and gene expressions.
The lab holds equipment that enables us to investigate the mitochondrial function in several different types of tissues (skeletal, smooth and cardiac muscle, adipose and hepatic tissue).
We focus on regulatory mechanisms of oxygen transport and utilization in humans at rest and during exercise in health and in various pathological states, and the adaptations to exercise training, diet intervention and environment.
Equipment
- Oroboros 2k, Innsbruck Austria (measures of oxygen consumption, membrane potential, ROS production)
- Seahorse, Boston USA (measures of oxygen consumption and pH)
- SAFAS, Monaco (flour spectrophotometer for measures of mitochondrial free radical production and mitochondrial membrane potential).
If you would like more information about the research or the equipment, please contact Steen Larsen stelar@sund.ku.dk.
Compartmentalized Metabolism
The focus of this research area is investigation of the role of intracellular compartmentalization of cellular processes on their regulation. We have described several novel regulatory mechanisms by which cells regulate metabolic pathways through the compartmentalization of substrates, enzymes and signaling molecules e.g.:
- Gathering of glycogen related enzymes on a spherical structure formed in cells with critically low levels of glycogen to increase re-synthesis efficiency (Prats et al. 2006 and 2009),
- Insulin stimulation signaling travels through the transverse tubuli membrane towards the inner regions of muscle fibers (Lauritzen et al. 2006)
- Hormone Sensitive Lipase needs to translocate to the lipid droplets surface in order to utilize skeletal muscle triacylglycerides (Prats et al 2006).
Recently, using high resolution confocal microscopy, we have reported severe morphological alterations in the quality of skeletal muscle lipid droplets and mitochondrial networks in subjects with morbid obesity, alterations that are reversed with surgery-induced weight loss and linked to improvements in insulin sensitivity ( Kristensen et al 2018).
Research focus
- Lipid droplets coating by PLINs and morphological integrity
- Mitochondrial networks structural organization and dynamics. Link to organelle function
- Glycogen storage quality and role of intracellular compartmentalization in the regulation of glycogen metabolism
- Microscopy – super resolution structured illumination microscopy to investigate intracellular structure of compartments and their interaction
- Carnitine transporter OCTN2, regulation by insulin and effects of severe mutations on whole body health
If you would like more information, please contact Clara Prats, cprats@sund.ku.dk.
Muscle physiology
Our research focuses on:
- Understanding the molecular and cellular mechanisms causing acquired and genetic muscle disorders (eg congenital myopathies, muscular dystrophies, ageing syndromes)
- Testing exercise as a countermeasure
- Providing sufficient knowledge to identify drug targets and to design novel therapeutic interventions in preclinical animal models.
Our laboratory uses human and animal muscle samples, and techniques ranging from single-molecule biophysics to muscle cell physiology and from X-ray diffraction to high-resolution confocal/super-resolution microscopy
If you would like more information, please contact Julien Ochala, julien.ochala@sund.ku.dk
Physical activity and Health: Exercise is Medicine
In this line of research we study cardiovascular and metabolic adaptations to physical activity and inactivity, sport and physical training in healthy and diseased (e.g. type 2 diabetes, obesity, metabolic syndrome), young and old people.
We focus on cross-sectional and longitudinal human studies, using advanced physiological techniques, including methods for:
- Blood and tissue (muscle and adipose tissue) sampling.
- Body composition (weight, height, DXA scanning, Bio-impedance).
- Cardio-respiratory fitness (V̇O2max).
- Resting Metabolic Rate, substrate utilisation, maximal fat oxidation.
- Muscle strength and power (handgrip dynamometer, Kin-Con (isometric-, isokinetic and-isotonic), Nottingham Power-rig).
- Functional tests (6 min walk test, Chair-Stand-Test etc.).
- Blood flow (strain gauge plethysmography, Ultrasound Doppler).
- Arterio-venous catheterization (forearm, leg).
- Eu-/iso- glycemic hyperinsulinemic clamp, hyperglycemic clamp, oral glucose or lipid tolerance test, meal test.
Ongoing research projects in Xlab
| Acronym | Title/content | PI | Collaborators |
|---|---|---|---|
|
UBBERUP |
The factors that determine maintenance of lifestyle modifications and weight loss (WB-longitudinal) |
JWH |
SDJ, SL, FD, MGN, CS, CP, KBC, MD, KH, SODJ, SOL |
|
UBBERUP |
Lifestyle intervention; effects on AT-inflammation |
JWH |
RES, SL, FD, CGP, SDJ |
|
Mitobolism |
Effect of physical inactivity on mitochondria dynamics |
CPG |
JWH, FD, AWH |
|
Lipid in aging |
The influence of age and training on muscle lipids. DAG and Ceramide content; effect of age. Biopsies waiting for analysis, WB in progress |
JWH |
DK, FD, CPG |
|
GASMITO |
Liver analysis - Ceramide and DAGS |
JWH |
FD, MTL, MHa, CPG, ALJ, MDK |
|
FASTMAX |
Fasting or CHO meals in four repeated FATMAX on two separate days (kvinder) |
JWH |
JF, SDJ, SDS, SL |
|
CIRCADIAN |
Mice – Mito respiration 24/7 |
SL |
MA, GZH |
|
PALERMO |
Moderate intensity, long term training, Young/Old |
JWH |
RS, JF, SL, MML-O, ABN, TR |
|
Bioage |
Study in progress |
JWH |
KSH, MR, PH, FD |
|
iTAPH |
Biological drug treatment of Psoriasis effect on inflammation |
JWH |
RES, FD, SFT |
|
Horses |
Mito respiration in heart tissue |
SL |
FD, JWH, RK |
|
CTD |
Carnitine Transport Deficiency - Insulin effect, mito function and transport regulation |
CPG |
SL, FD, JWH |
|
TAW |
Maximal fat oxidation in young and old trained and untrained women |
JWH |
MO, MBA, FM, JF, RES, SL |
|
GLP1-Exisecret |
Interaction of aerobic exercise and GLP-1 receptor agonist treatment on beta cell function in T2DM |
FD |
AI, MS, TT, BG, JWH |
|
BeetOX |
The effects of beetroot juice supplementation on oxygen availability and efficiency at whole-body, muscle and mitochondrial level at rest and during exercise in type 2 diabetes and ageing. |
SL |
FD, JWH, AI, MS, TT, BG |
|
Norsecret |
The role of Noradrenaline in beta-cell adaptations to exercise, in patients with type 2 diabetes and healthy controls |
FD |
AI, MS |
|
Ventriject |
Validation of method to determine maximal oxygen uptake at rest using Ventriject equipment and validated towards direct measurement of VO2max. |
JWH |
MTH, TR |
|
Østersøen rundt |
Study of extreme long term exercise. Study in progress, testing controls |
JWH |
MTH, TR, JF, SL, FD, RES, |
|
Ubberup - bioage validation |
Validating measurement of Biological age at Ubberup. |
JWH |
KSH, FD, SL, |
|
SGLT2 infarct |
The effect of SGLT2 inhibitors on mitochondrial function after an infarct. |
SL |
KD, TJ, LO, FD, JWH |
|
HiLoMFO |
Maximal fat oxidation and fuel use during exercise |
JWH |
SGV |
In writing
| Acronym | Title/content | PI | Collaborators |
|---|---|---|---|
|
GREENLAND |
The influence of prolonged low intensity exercise on metabolism |
JWH |
RB, AVH, TMA |
|
HR-MAX |
Influence of CVP and maximal heart rate in trained and untrained individuals |
JWH |
RB, JC, FP, MH |
|
Local Kick |
The influence of graded exercise on VLDL uptake |
JWH |
FD, BS, LBN, EB, MP |
|
LEPTIN RESP |
The in vitro influence of leptin on respirometry |
JWH |
FD, SL, MTL, AGG |
|
HIGH FAT DIET II |
The effect of HFD and training on mitochondrial respiration |
FD |
MSK, CPG, JWH, CNH |
|
GIP, GLP-1 AFTER HIT |
The effects of HIT on GIP and GLP-1 |
JWH |
MHi, TLD, MTL, SL, (JK), FD, JWH |
|
Mito O2 |
Investigating the effect of different O2 concentrations on mitochondrial function |
SL |
FD, JWH |
|
Mito-met |
Method paper. Blebistatin + |
SL |
RK, MG, SL, TLD, MTL, JWH, FD |
|
IFAST mito |
The effect of intermittent fasting on ROS production and mitochondrial respiration in patients with type 2 diabetes |
FD |
SL, SS, JWH, AI |
|
ROS and HIT |
The effect of HIT on ROS production |
SL |
RK, JWH, FD, MG |
|
EPO - acute |
Double blind infusion of EPO / Saline; effect on mito resp., muscle signaling |
SL |
SDS, JWH, THM, JF, RS, FD |
|
E DM2 |
Energy storage quality and DM2 |
CPG |
AG, JWH, FD |
|
Bioage |
Establishing and validating a new method to determine biological age. Initial protocol article submitted - main article in writing. |
JWH |
KSH, MF, PH |
|
HVIDOVRE |
Liver and adipose samples from Hvidovre - respiration |
FD |
JWH, SL, KK, MA |
Submitted
| Acronym | Title/content | PI | Collaborators |
|---|---|---|---|
|
KO ampkα2 |
AMPK KO inducible method |
SL |
JW, TLD |
|
PIGS |
Mitochondrial function in liver, heart and muscle (submitted) |
SL |
LBC, JWH, FD, TLD |
|
DIMITOS |
Glutathione supplementation in patients with type 2 diabetes and matched controls |
SL |
SDS, MA, FD, JWH |
|
VASA |
Vasa race performance and validation Thorax test. Submitted. |
JWH |
MTH, TR, JF, FD, SL |
|
LIFESTAT |
Living with Statins (blood and muscle analyses). 2 final manuscripts submitted. |
FD |
JWH, SL, TLD, THM, ABK |
|
EMT |
Eccentric training in the elderly. Manuscript submitted |
FD |
AKK, FOL, SR |
|
SUND |
Health evaluation at Sundhedsdoktor (submitted) |
JWH |
KSH, SGV, CR |
Abbreviations
| Abbreviation | Name |
|---|---|
| ABK | Anja Birk Kuhlman |
| ABN | Andreas Blåholm Nielsen |
| AGG | Amelia Guadalupe Grau |
| AI | Arthur Ingersen |
| AKK | Anna Karnøe Knudsen |
| ALJ | Anne Line Jørgensen |
| AV | Allan Vaag |
| AVH | Andreas Vigelsø Hansen |
| BS | Bente Stallknecht |
| CNH | Christina Neigaard Hansen |
| CP | Charlotte Præst |
| CPG | Clara Prats Gavalda |
| CS | Camilla Skovborg |
| DS | Ditte Søgaard |
| EB | Emil Bartels |
| FD | Flemming Dela |
| FJAP | Fransisco J. Amaro Gahete |
| FLC | Francisco Llorente Cantarero |
| FON | Filippa Orlien Lindskov |
| FP | Frank Pott |
| HHHP | Helga Huld Halldórsdóttir Petersen |
| IA | Ignacio Ara |
| JB | Jens Bruun |
| JBJ | Jette Bork-Jensen |
| JC | Jim Cotter |
| JF | Jacob Frandsen |
| JK | Jonas Kuylenstierna |
| JP | Julia Prats |
| JT | Jonas Treebak |
| JW | Jørgen Wøjtaszewski |
| JWH | Jørn Wulff Helge |
| KBC | Kasper Bøgh Christensen |
| KH | Karina Husted |
| LBC | Liselotte Bruun Christiansen |
| MA | Magnus Asping |
| MGN | Malene Glerup Nielsen |
| MH | Mikkel Holst |
| MHa | Merethe Hansen |
| MHi | Morten Hindsø |
| MMK | Malene Maag Kristensen |
| MML-O | Michelle Munk Lie-Olsen |
| MP | Martin Petersen |
| MSk | Mette Skovbro |
| MTL | Michael Taulo Lund |
| NBA | Nynne Bjerre Andersen |
| NP | Nina Pistoljevic |
| PA | Pernille Auerbach |
| RB | Rob Boushel |
| RK | Regitze Kraunsøe |
| RS | Ronni Sahl |
| SGV | Sofie Greve Vestergaard |
| SDJ | Sune Dandanell Jørgensen |
| SDS | Stine Dam Søndergård |
| SDV | Stine Dahl Vest |
| SL | Steen Larsen |
| SoDJ | Sofie Drevsholt Jørgensen |
| SoL | Sofie Lionett |
| SR | Signe Regnersgaard |
| SS | Stinna Skaaby |
| TB | Thomas Beck |
| THM | Thomas Hoffmann Morville |
| TLD | Tine Lovsø Dohlmann |
| TMA | Thor Munch Andersen |
| TP | Thorkil Ploug |
| TR | Tue Rømer |
| ZG-H | Zach Gerhart-Hines |
Major Grants (> DKK 500,000)
The Danish Diabetes Academy, DKK 1,500,000
3x1/3 PhD stipend salary (2014-2017, 2014-2017, 2016-2018)
Grant recipient: Jørn Wulff Helge
UCPH Excellence Programme for Interdisciplinary Research
(2016 Funds, University of Copenhagen) (2013). PI: Flemming Dela
Project: Living with Statins - high cholesterol values in the blood; a social, medical and personal perspective (LIFESTAT)
Interdisciplinary project: Faculty of Health and Medical Sciences, Faculty of Social Sciences, Faculty of Humanities.
The Danish Council for Independent Research Individual Postdoc stipend
DKK 2,807,204 (2015)
Grant recipient: Steen Larsen
The Danish Council for Independent Research | Medical Sciences,
DKK 2,839,608 (2012-2016)
Grant recipient: Flemming Dela
Project: Oscillations in skeletal muscle energy stores as a regulator of insulin resistance.
EU, 7th framework programme, EURO 6,000,000 (2011-2015)
Co-PI: Jørn Wulff Helge
Project: "META-PREDICT" - "Developing predictors of the health benefits of exercise for individuals".
The Danish Council for Strategic Research, DKK 18,700,304 (2011-2015)
Grant recipient: Flemming Dela
Project: GASMITO: The effect of gastric bypass surgery on glucose and lipid metabolism and mitochondrial respiration.
The Danish Council for Independent Research | Medical Sciences, DKK 2,992,680 (2010-2012)
Grant recipient: Flemming Dela
Project: Mitochondrial function in the failing human heart.
Hørslev Foundation
DKK 715,500 (2010)
Grant recipient: Flemming Dela
Project: Metabolic changes after weight loss with gastric bypass: studies of overweight people with and without type 2 diabetes.
Nordea Foundation
DKK 150,000,000 (2009-2013)
Co-PI: Flemming Dela
Project: "Molekyler og celler: Muskel- og bindevæv".
Beckett Foundation
DKK 300,000 (2009-2011)
Grant recipient: Flemming Dela
Project: Metabolic changes after weight loss with gastric bypass: studies of overweight people with and without type 2 diabetes.
The Danish Council for Independent Research | Medical Sciences
DKK 1,440,000 (2008-2010)
Grant recipient: Flemming Dela
Project: Mitochondrial function in healthy and insulin resistant human skeletal muscle and adipose tissue.
Købmand i Odense Johann og Hanne Weimann f. Seedorffs Legat
DKK 1,013,000 (2008)
Grant recipient: Clara Prats Gavalda
Two years postdoctoral Fellowship.
Tryg Foundation & Danish Ministry of Health
DKK 24,000,000 (2006-2009)
Co-PI: Jørn Wulff Helge
Project: KRAM - Investigation of the Health of Danes, DANHES.
The Danish Council for Independent Research | Medical Sciences
DKK 840,000 (2006-2007)
Grant recipient: Flemming Dela
Project: Mitochondrial function in human skeletal muscle.
Lundbeck foundation
DKK 1,000,000 (2005)
Grant recipient: Flemming Dela
Project: Mitochondrial function in human skeletal muscle.
EU, 6th framework programme, EURO 600,000 (2004-2009)
Co-PI: Flemming Dela
Project: "EXGENESIS": Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome.
Birthe & John Meyer Foundation
DKK 2,000,000 (2004-2006)
Co-PI: Jørn Wulff Helge
Project: Effekt af helkropstræning på arm og ben metabolismen.
Ministry of Culture. Committee on Exercise Sports Science Research
DKK 600,000, (2000)
Grant recipient: Flemming Dela
Project: Exercise and insulin action.
The Danish Council for Independent Research | Natural Sciences; Technology by Highly Oriented Research (THOR), DKK 520,000 (1998)
Grant recipient: Flemming Dela
Project: Proteome analysis of insulin resistance.
Danish Medical Research Council - Danish Research Agency
DKK 523,200 (1998)
Grant recipient: Flemming Dela
Project: Insulin mediated regulation of human glucose and protein metabolism. Importance of physical activity and training.
Team Danmark
DKK 1,150,000 (1993-1996)
Grant recipient: Jørn Wulff Helge
Project: Kostens betydning for adaptation til træning.
Grants < DKK 500,000
- All@once EIT Health Education (2018)
- Augustinus Foundation (2008, 2012, 2018)
- Astra Zeneca (2005)
- Beckett Foundation (2009, 2017, 2018, 2019)
- Bjarne Jensens Foundation (2017)
- Brødrene Hartmanns Fonden (2018, 2019)
- Carl Ellen Hertz family legacy (2004)
- Danish Diabetes Association (1987, 1988, 1989, 1990, 1991, 1994, 1997, 1998, 2000, 2002, 2003, 2004, 2005, 2007)
- Danish Medical Association (1994, 1988).
- Danish Medical Research Council (1988, 1995, 1996, 1999, 2003)
- Ib Henriksens Foundation (1989, 1990, 1991, 1995, 1998, 2000, 2001, 2016)
- J. Madsen and Olga Madsen Foundation (1990, 1991, 1992, 1999, 2000, 2003, 2010)
- and H.C. Adolf Holms Memorial Legacy (2005)
- and M. Wedell-Wedellsborgs Foundation (1991, 2002, 2003, 2005, 2006, 2009, 2010, 2012)
- EIT Health (2018)
- Eva and Henry Frænkels Memorial Fund (2014)
- Foundation of 1870 (1990, 1991, 1997, 1998, 1999, 2000, 2003, 2004, 2005, 2015)
- Fonden til Lægevidenskabelig Fremme (A.P. Møller) (1987, 1988, 1996, 1997, 2006, 2007, 2008, 2010, 2019)
- Gerda and Aage Haensch Foundation (1988)
- Helsefonden (2018, 2019)
- Kathrine and Vigo Skovgaards Foundation (2008, 2009, 2010, 2012, 2013, 2014, 2015)
- King Christian X Foundation (1987, 1991, 1995, 2004, 2007, 2014, 2017)
- Kurt Bønnelycke and Grethe Bønnelyckes Foundation (2010)
- Lundbeck Foundation (2012)
- Ministry of Culture (2005, 2019)
- Ministry of Culture, Committee on Exercise Sports Science Research (1997, 1998, 1999, 2001, 2002, 2003)
- Merchant Ernst Fischers legacy (2008)
- Meyer Nielsens and wife memorial award (2010)
- Miss P.A. Brandts legacy (2004)
- Mogens and Jenny Vissings Foundation (1991)
- Novo Nordisk Foundation (1987, 1988, 1989, 1991, 1993, 1998, 1999, 1990, 1995, 1994, 1997, 2001, 2002, 2004, 2005, 2006, 2007, 2010)
- Novo Nordisk Foundation, Nordic Research Committee (1989, 1990, 1991, 1992, 1993, 1997, 1999, 2002, 2004, 2005)
- Novo Nordisk Foundation, Nordic Insulin Committee (2989, 1991, 1992, 1993)
- Novo-Fab. V. Pedersen Memorial Legacy (2003, 2004)
- Oda and Hans Svenningsens Foundation (2007, 2013, 2017)
- Carl Petersens Foundation (1988, 1990, 1998, 2000, 2012, 2013, 2015)
- Pharmacy Foundation
- Research Academy (1994)
- Simon Fougner Hartmanns Family Foundation (2005, 2013)
- Snedkermester Jacobsens Foundation (2016)
- Sophus and Astrid Jacobsens Foundation (2016)
- SUND (2016)
- Sygekassernes Helsefond (1991)
- Team Danmark (1991, 1994, 1997, 1998, 1999, 2000, 2007, 2016)
- The Danish Heart Association (1990, 1991, 1992, 1994, 1999, 2001, 2014)
- The Ministry of Culture Committee on Sports Research (1987, 1988, 1989, 1990, 1996, 1997, 1998, 1999, 2016)
- University of Copenhagen Faculty of Health Sciences (1999)
- Verner Richter and wife legacy (2003)
- Aage Louis-Hansens Memorial Foundation (1990, 1997)
- Aase and Ejnar Danielsens Foundation (2005, 2006, 2008, 2010, 2012, 2015, 2016, 2019)
Xlab is responsible for multiple events and courses. You can read about upcoming events and courses as well as past events and courses.
Upcoming Events and Courses
Currently no upcoming events
Past Events and Courses
- Mitochondrial Physiology Summer School 2019 – From Organelle to Organism, 19-23 August
- Mitochondrial Medicine Symposium, 9 March 2018
- Cellular Bioenergetics Course 5-8 March 2018
- Mitochondrial Physiology Summer School 2017
- Mitochondrial Physiology Summer School 2015 - From Organelle to Organism
- Mitochondrial Physiology Summer School 2013
- Graduate Course 2010
Stine Dam Søndergård - PhD defence
“The production of reactive oxygen species in response to glutathione supplementation and acute exercise in patients with type 2 diabetes”
The defence took place on 1 April 2019
Supervisor: Associate Professor Steen Larsen
Anja Birk Kuhlmann - PhD defence
“The influence of statin use, CoQ10 supplementation and exercise on glucose homeostasis”
The defence took place on 13 December, 2018
Principal supervisor: Professor Flemming Dela
Co-supervisor: Professor Jørn Wulff Helge
Thomas Hoffmann Morville - PhD defence
“Glucose homeostasis and physical performance in Danish statin users in primary prevention”
The defence took place on 9 November, 2018
Principal supervisor: Professor Jørn Wulff Helge
Ditte Søgaard - PhD defence
“The influence of age and training on human muscle bioactive lipids and coupling to insulin resistance”
The defence took place on 11 January, 2018
Principal supervisor Professor Jørn Wulff Helge
Tine Lovsø Dohlmann - PhD defence
“Role of mitochondria in statin induced myalgia”
The defence took place on 21 December 2017
Principal supervisor: Professor Flemming Dela
Marianne Dalsgaard Kristensen - PhD defence
"Lipid stress and chronic low grade inflammation with obesity and weight loss - association with insulin sensitivity"
The defence took place on 7 September, 2017
Principal supervisor: Associate Professor Clara Gavalda Prats
Co-supervisor: Professor Flemming Dela
Malene Maag Kristensen - PhD defence
"Influence of changes in levels of activity and weight loss on the expression of miRNAs in human adipose and muscle tissue"
The defence took place on 20 April, 2017
Principal supervisor: Professor Flemming Dela
Sune Dandanell - PhD defence
"Physiological factors that influence weight loss maintenance after a lifestyle intervention"
The defence took place on 23 March, 2017
Principal supervisor: Professor Jørn Wulff Helge
Co-Supervisor: Professor Flemming Dela
Merethe Hansen - PhD defence
"Effects of Exercise, Metformin, Diet and Roux-en-Y Gastric Bypass on Glucose Homeostasis in Type 2 Diabetes Patients - Studies on different treatment approaches"
The defence took place on 24 October, 2016
Principal supervisor: Professor Flemming Dela
Co-Supervisor: Professor Jørn Wulff Helge
Cathrine Lawaetz Wimmelmann - PhD defence
"Psychological aspects of obesity and bariatric surgery: A prospective study of psychological factors among bariatric patients undergoing Roux-en Y gastric bypass"
The defence took place on 19 January, 2016
Supervisors: Professor Flemming Dela and Professor Erik Lykke Mortensen, Section of Environmental health, University of Copenhagen
Andreas Vigelsø Hansen - PhD defence
"The effect of 2 weeks’ immobilization and 6 weeks’ aerobic training on muscle function and metabolism in young and older men”
The defence took place on 4 June, 2015
Principal supervisor: Professor Jørn Wulff Helge
Co-Supervisors: Professor Flemming Dela and Associate professor Clara Prats
Jayson Reed Gifford - PhD defence (University of Utah, Dept. of Exercise and Sport Science)
“N/A”
The defence took place in 2015
Supervisors: Professor Flemming Dela & Professor Russ Richardson (University of Utah, Vascular Research Lab.)
Steen Larsen - Doctoral thesis defence
”Mitochondrial function in human skeletal muscle: Influence of age, physical fitness and insulin sensitivity”
The defence took place on 5 February 2014
Martin Gram - PhD defence
"Mitochondrial function in young and elderly men after immobilization and aerobic retraining"
The defence took place on 19 December, 2014
Principal supervisor: Professor Flemming Dela
Co-Supervisors: Postdoc Martin Hey-Mogensen, Sciences, Professor Jørn Wulff Helge
Michael Taulo Lund - PhD defence
“The influence of lifestyle interventions on glucose homeostasis”
The defence took place on 4 September, 2014
Supervisors: Professor Flemming Dela, Associate Professor Jørn Wulff Helge, and Karsten Bech, MD, DMSc, MPA, Centerchef ”Organkirurgisk Klinik”, Sønderjylland Hospital, Denmark
Dace Reihmane - PhD defence (University of Riga, Latvia).
“Inflammation in trained and untrained humans”
The defence took place in 2014
Supervisors: Professor Flemming Dela & professor P Tretjakovs University of Riga, Latvia.
Liselotte B. Christiansen - PhD defence (Dept. of Biomedical Sciences/ Dept. of Small Animal Research)
“Mitochondrial structure and function in feline hypertrophic cardiomyopathy – An animal model of spontaneous disease”
The defence took place December 17th , 2014
Supervisors: Professor Flemming Dela & Associate professor Jørgen Koch
Thor Munch-Andersen - PhD defence
“Metabolic health in children and adult Greenlandic Inuit”
The defence took place on 11 December, 2013
Supervisor: Associate Professor Jørn Wulff Helge
Nis Stride - PhD defence
"Mitochondrial function in hear failure and cardiac ischemia"
The defence took place on 16 November, 2012
Supervisor: Professor Flemming Dela
Mette Skovbro-Grønvall - PhD defence
"The effect of high fat diet with or without concomitant exercise training on mitochondrial function and insulin sensitivity in healthy human skeletal muscle"
The defence took place on 27 June, 2011
Supervisors: Professor Flemming Dela and Associate professor Robert Boushel
Pernille Nordby - PhD defence
"Exercise vs. dieting in improving health in overweight men"
The defence took place on 15 April, 2011
Supervisors: Associate professor Bente Merete Stallknecht, Associate professor Jørn Wulff Helge, Professor Flemming, and Professor Jens Juul Holst
Lise Højbjerre - PhD defence
"Physical inactivity, adipose tissue metabolism and inflammation in type 2 diabetes predisposition"
The defence took place on 2 December, 2010
Supervisors: Associate professor Bente Merete Stallknecht, Professor Flemming Dela, Professor Allan Vaag, Steno Diabetes Center
Iben Kynde - PhD defence
”Associations between dietary carbohydrates and metabolic risk factors in Danish children and adolescents” based on cross-sectional and prospective analyses of the European Youth Heart Studies I and II.
The defence took place on 11 February, 2010
Supervisors: Associate professor Jørn Wulff Helge, Professor Berit Lilienthal Heitman, Research Unit for Dietary Studies, Institute of Preventive Medicine, Copenhagen University Hospital, Professor Ib Christian Bygbjerg, Department of International Health, Immunology & Microbiology, Copenhagen University.
Celena Scheede-Bergdahl - PhD defence
Insulin action and endothelial function in type 2 diabetes: effects of a moderate intensity home-based training programme.
The defence took place on 23 September, 2009
Supervisor: Professor Flemming Dela
Mette Pauli Sonne - PhD defence
The effect of physical inactivity on insulin sensitivity and endothelial function in humans at risk of developing type 2 diabetes.
The defence took place on 15 June 15, 2009
Supervisor: Professor Flemming Dela
Rasmus Rabøl - PhD defence
Mitochondrial function in skeletal muscle in type 2 diabetes.
The defence took place on 9 January, 2009
Supervisor: Professor Flemming Dela
Danielle Battram - PhD defence (University of Guelph, Canada)
“The effect of caffeine on glucose kinetics”
The defence took place in 2006
Supervisors: Professor Flemming Dela & professor Terry Graham University of Guelph, Canada.
Alle studieretninger – emner egnet til både BA og MA specialer.
Vi beskæftiger os med fysisk aktivitet og inaktivitet indflydelse betydning for organismens funktioner. Nedenfor ses en liste af emner/stikord som du måske kan genkende dig selv i?
- Kardiovaskulær, metabolisk og morfologisk adaptation til fysisk træning og inaktivitet
- Fysisk træning i forebyggelsen og behandlingen af Type 2 diabetes
- Insulin sekretion og insulin resistens
- Mitokondrie fysiologi – hvordan omsættes næringsstofferne til energi?
- Intramuskulært fedt hos atleter og insulin resistente personer. Hvordan hænger det sammen?
- FatMax – evnen til af forbruge fedt som brændstof under fysisk aktivitet
- Mitokondrielle netværk i muskler hos patienter med diabetes og/eller fedme. Belyst ved avanceret mikroskopi
- Carnitine transport regulation by insulin
- Fysisk træning af ældre mennesker mhp. at forebygge tab af muskelmasse- og styrke
- Sarcopeni – betydning, forebyggelse og behandling
- Body-Age – er det rent fup?
- Livsstilsintervention - fastholdelse af gode livsstilsvaner
+ Mange andre muligheder, gerne tilpasset dine interesser inden for fysisk aktivitet og sundhed.
Er du interesseret, så skriv til:
Professor Flemming Dela,fdela@sund.ku.dk
Professor Jørn Wulff Helge,jhelge@sund.ku.dk
Lektor Steen Larsen,stelar@sund.ku.dk
Lektor Clara Prats,cprats@sund.ku.dk
Specifikke projekter:
- Metabolic and mitochondrial effects of Breast Cancer Treatment
Kontakt postdoc Linn Gillberg - Physiological and Nutritional Effects on Maximal Fat Oxidation
Kontakt: PhD Sofie Vestergaard
Location of Xlab
Xlab is part of the Department of Biomedical Sciences located in the Maersk Tower at floor 2.
How to get to Panum when arriving at the airport
When you arrive at Copenhagen International Airport Kastrup, take the metro to Nørreport Station. This takes about 15 minutes. Tickets can be purchased at the ticket stand (DSB) located in the airport terminal.
From Nørreport Station take bus 6A, 42, 43, 150S or 185 to the bus stop Tagensvej/Blegdamsvej. This takes about 10 minutes, and you can use the ticket which you have bought in the airport. Use the journey planner to plan your trip.
Taxi: A taxi fare from the airport to Panum costs about DKK 250. Taxi fares include VAT and tips, and you can normally pay by credit card.
How to get to Panum when arriving by train
From Copenhagen Central Station (Hovedbanegården) take bus 5A or 6A to the bus stop Tagensvej/Blegdamsvej. It takes about 20 minutes. Tickets can be purchased on the bus and cost about DKK 24. Use the journey planner to plan your trip.
Information to foreigners
When your start working at the Xlab, secretary Jacqueline van Hall can help you with practical matters.
By clicking at the links below, you can find some general information for foreign researchers and students working at the University of Copenhagen. Please note that the two sites are only meant to give you some preliminary guidance. You should always contact the relevant Danish authorities for the most updated and precise information.
Xlab is currently looking for participants for several studies
We are looking for both fit and unfit women for a study
We are looking for women who is either very fit or unfit in between the age of 18-35 years old, 50-65 years old and 70-80 years old. In the unfit group are we looking for women with normal BMI as well as BMI above 30. The aim of the study is to examine the effect of age, degree of fat and fitness level on the maximum fat oxidation in women.
Read more about participating in the study of maximum fat oxidation in women
We are looking for participants with type-2 diabetes for exercise study
We are looking for participants with type-2 diabetes for an exercise study. The aim of the study is to find out how physical exercise and medical treatment of your diabetes work together.
Read more about the exercise study
We are looking for male participants for a study
We are looking for participants for a study on the effect of beetroot juice on the oxygen delivery in the muscles during rest and work. The participant must be a male between the ages of 40-80.
Read more about participating in the study
We are looking for healthy and fit women for a study
We are looking for healthy and fit women between the age of 20-40 years old for the research project, ”Maximum fat oxidation; effect of fasting and relation to performance”, where we want to examine the effect of fasting on the maximum fat oxidation.
Read more about the "Maximum fat oxidation" study
We are looking for moderate to well trained male participants for the study from September 2020
We are looking for healthy and moderate to well-trained male participants for a study investigating the effect of a 3 days diet on the maximal fat oxidation during exercise. The participants have to be between 18 and 40 years old.
Read more about the requirements for participating in the study
Senior researchers in Xlab
| Name | Title | Phone | |
|---|---|---|---|
| Flemming Dela | Professor | +45 353-27425 | |
| Jørn Wulff Helge | Professor | +45 287-57506 | |
| Clara Prats | Associate professor | +45 353-30706 | |
| Steen Larsen | Associate professor | +45 211-51924 | |
| Julien Ochala | Associate professor |
Group members
Xlab is part of
