Ochala Group - Muscle Cell Biophysics

Julien Ochala's pioneering research combines evolutionary biology, biophysics, and molecular medicine to uncover how nature's diverse myosin variants dynamically reshape muscle metabolism and mechanics under extreme physiological and pathological contexts.

By dissecting the molecular "code" embedded in sarcomeric proteins, his team aims to engineer next-generation, precision-targeted therapies that reprogramme dysfunctional muscle cells at their core.

This visionary programme not only bridges fundamental muscle mechanobiology with translational breakthroughs but also pioneers the use of comparative vertebrate models as living blueprints to inspire innovative interventions addressing critical illnesses, genetic myopathies, and metabolic syndromes.

This approach positions muscle myosin not merely as a biomolecule but as a molecular switchboard for tailoring muscle resilience and recovery in diverse thoracic and systemic conditions.’