Morten Schak Nielsen
Associate Professor
Physiology of circulation, kidney and lung
Blegdamsvej 3
2200 København N.
- Published
ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.
Xing, D., Kjølbye, A. L., Nielsen, Morten Schak, Petersen, J. S., Harlow, K. W., Martins, J. B. & von Holstein-Rathlou, Niels-Henrik, 2003, In: Cardiovascular Electrophysiology. 14, 5, p. 510-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synopsis of the International Gap Junction Conference in Elsinore, Denmark August 5-9, 2007.
Willecke, K. & Nielsen, Morten Schak, 2008, In: Cell Communication & Adhesion (Print Edition). 14, 6, p. 251-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Thorsen, K., Dam, V. S., Kjaer-Sorensen, K., Pedersen, L. N., Skeberdis, V. A., Jurevicius, J., Treinys, R., Petersen, I. M. B. S., Nielsen, Morten Schak, Oxvig, C., Morth, J. P., Matchkov, V. V., Aalkjær, Christian, Bundgård, Henning & Jensen, H. K., 22 Nov 2017, In: Nature Communications. 8, 10 p., 1696.Research output: Contribution to journal › Journal article › Research › peer-review
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Uremia increases QRS duration after β-adrenergic stimulation in mice
Thomsen, Morten Bækgaard, Nielsen, Morten Schak, Aarup, A., Bisgaard, Line & Pedersen, T. X., 1 Jul 2018, In: Physiological Reports. 6, 13, 13 p., e13720.Research output: Contribution to journal › Journal article › Research › peer-review
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Maxi K+ channels co-localised with CFTR in the apical membrane of an exocrine gland acinus: possible involvement in secretion
Sørensen, J. B., Nielsen, Morten Schak, Gudme, C. N., Larsen, Erik Hviid & Nielsen, R., 2001, In: Pflügers Archiv: European Journal of Physiology. 442, p. 1-11Research output: Contribution to journal › Journal article › Research › peer-review
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Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles.
Sorensen, Charlotte Mehlin, Salomonsson, M., Braunstein, T. H., Nielsen, Morten Schak & von Holstein-Rathlou, Niels-Henrik, 2008, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 295, 3, p. R840-7Research output: Contribution to journal › Journal article › Research › peer-review
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Gap junctions-guards of excitability
Stroemlund, L. W., Jensen, C. F., Qvortrup, Klaus, Delmar, M. & Nielsen, Morten Schak, 1 Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 508-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein⁻Protein Interactions with Connexin 43: Regulation and Function
Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M. & Nielsen, Morten Schak, 10 May 2018, In: International Journal of Molecular Sciences. 19, 5, 21 p., 1428.Research output: Contribution to journal › Review › Research › peer-review
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Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles (American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2008) 295, (R840-R847) DOI:10.1152/ajpregu.00491.2007)
Sorensen, Charlotte Mehlin, Salomonsson, M., Braunstein, T. H., Nielsen, Morten Schak & Holstein-Rathlou, N. H., 1 Jan 2010, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 1Research output: Contribution to journal › Comment/debate › Research › peer-review
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Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium
Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, Sofia Hammami, Nielsen, Morten Schak, Grunnet, Morten, Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathetic vasoconstriction takes an unexpected pannexin detour
Nielsen, Morten Schak, 17 Feb 2015, In: Science Signaling. 8, 364, p. 1-2 2 p., fs4.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury
Rusiecka, O. M., Molica, F., Nielsen, Morten Schak, Tollance, A., Morel, S., Frieden, M., Chanson, M., Boengler, K. & Kwak, B. R., 2023, In: Cardiovascular Research. 119, 13, p. 2342-2354Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of connexin43 on serine 306 regulates electrical coupling
Procida, Kristina, Jørgensen, L., Schmitt, Nicole, Delmar, M., Taffet, S. M., von Holstein-Rathlou, Niels-Henrik, Nielsen, Morten Schak & Braunstein, T. H., 2009, In: Heart Rhythm. 6, 11, p. 1632-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative proteomics characterization of acutely isolated primary adult rat cardiomyocytes and fibroblasts
Poulsen, P. C., Schrölkamp, Maren, Bagwan, N., Leurs, U., Humphries, E. S. A., Bomholzt, S. H., Nielsen, Morten Schak, Bentzen, Bo Hjorth, Olsen, Jesper Velgaard & Lundby, Alicia, 2020, In: Journal of Molecular and Cellular Cardiology. 143, p. 63-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats
Olsen, Kristine Boisen, Axelsen, L. N., Braunstein, T. H., Sorensen, Charlotte Mehlin, Andersen, C. B., Ploug, Thorkil, von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 2013, In: Cardiovascular Diabetology. 12, p. 19 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Angiotensin II does not acutely regulate conduction velocity in rat atrial tissue
Olsen, Kristine Boisen, Braunstein, T. H., Sorensen, Charlotte Mehlin, Axelsen, L. N., von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 6 Jul 2011, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 71, 6, p. 492 499 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Estimation of the effective intercellular diffusion coefficient in cell monolayers coupled by gap junctions
Olesen, N. E., Hofgaard, J. P., von Holstein-Rathlou, Niels-Henrik, Nielsen, Morten Schak & Jacobsen, Jens Christian Brings, 2012, In: European Journal of Pharmaceutical Sciences. 46, 4, p. 222-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probenecid inhibits α-adrenergic receptor-mediated vasoconstriction in the human leg vasculature
Nyberg, M. P., Piil, P. B., Kiehn, O. T., Maagaard, C., Jørgensen, T. S., Egelund, J., Isakson, B. E., Nielsen, Morten Schak, Gliemann, Lasse & Hellsten, Ylva, 2018, In: Hypertension. 71, 1, p. 151-159 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gap Junctions
Nielsen, Morten Schak, Axelsen, L. N., Sorgen, P., Verma, V., Mario, D. & von Holstein-Rathlou, Niels-Henrik, 2012, In: Comprehensive Physiology. 2, p. 1981-2035Research output: Contribution to journal › Review › Research › peer-review
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Effect of carbachol and prostaglandin E2 on chloride secretion and signal transduction in the exocrine glands of frog skin (Rana esculenta)
Nielsen, Morten Schak & Nielsen, R., 1999, In: Pflügers Archiv: European Journal of Physiology. 438, p. 732-740Research output: Contribution to journal › Journal article › Research › peer-review
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Myocyte-fibroblast interactions--risky connections
Nielsen, Morten Schak, 2009, In: Heart Rhythm. 6, 11, p. 1650-1 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lateralized gap junctions in pulmonary hypertension - lost but not alone
Nielsen, Morten Schak, 2012, In: Heart Rhythm. 9, 7, p. 1141-1142 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
Nielsen, Morten Schak, van Opbergen, C. J. M., van Veen, T. A. B. & Delmar, M., 2023, In: Physiological Reviews. 103, 3, p. 2271-2319Research output: Contribution to journal › Review › Research › peer-review
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The basolateral Ca2+-dependent K+ channel in rat colonic crypt cells
Nielsen, Morten Schak, Warth, R., Bleich, M., Weyand, B. & Greger, R., 1998, In: Pflügers Archiv: European Journal of Physiology. 435, p. 267-272Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of cellular and paracellular ion fluxes in frog skin glands.
Nielsen, Morten Schak & Nielsen, R., 1993, Glasgow: XXXII Congress of the International Uni3. 21 p.Research output: Book/Report › Book › Research
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K+ is actively secreted in the frog skin gland.
Nielsen, Morten Schak & Nielsen, R., 1994, In: Acta Physiologica (Print Edition). 151, p. 26AResearch output: Contribution to journal › Journal article › Research › peer-review
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Structural determinants underlying permeant discrimination of the Cx43 hemichannel
Nielsen, B. S., Zonta, F., Farkas, T., Litman, Thomas, Nielsen, Morten Schak & MacAulay, Nanna, 2019, In: Journal of Biological Chemistry. 294, 45, p. 16789-16803 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pannexin 1 activation and inhibition is permeant-selective
Nielsen, B. S., Toft-Bertelsen, Trine Lisberg, Lolansen, Sara Diana, Anderson, C. L., Nielsen, Morten Schak, Thompson, R. J. & MacAulay, Nanna, 2020, In: The Journal of Physiology. 598, 2, p. 361-379 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics
Nielsen, B. S., Hansen, D. B., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, Sep 2017, In: Neurochemical Research. 42, 9, p. 2537–2550 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Permeant-specific gating of connexin 30 hemichannels
Nielsen, B. S., Alstrom, J. S., Nicholson, B., Nielsen, Morten Schak & MacAulay, Nanna, 2017, In: Journal of Biological Chemistry. 292, 49, p. 19999-20009Research output: Contribution to journal › Journal article › Research › peer-review
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Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43
Morel, S., Christoffersen, Christina, Axelsen, L. N., Montecucco, F., Rochemont, V., Frias, M. A., Mach, F., James, R. W., Naus, C. C., Chanson, M., Lampe, P. D., Nielsen, Morten Schak, Nielsen, L. B. & Kwak, B. R., 13 Jan 2016, In: Cardiovascular Research. 109, p. 385-396 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions
Mollerup, S., Hofgaard, J. P., Braunstein, T. H., Kjenseth, A., Leithe, E., Rivedal, E., von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 21 Sep 2011, In: Cell Communication & Adhesion (Print Edition). 18, 4, p. 57-65 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic connexin hemichannels are regulated by PKC phosphorylation in an isoform-specific manner
MacAulay, Nanna, Alstrom, J. S., Hansen, D. B. & Nielsen, Morten Schak, 2017, In: Glia. 65, S1, p. E64-E64 S17-01.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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RXP-E: a connexin43-binding peptide that prevents action potential propagation block
Lewandowski, R., Procida, Kristina, Vaidyanathan, R., Coombs, W., Jalife, J., Nielsen, Morten Schak, Taffet, S. M. & Delmar, M., 2008, In: Circulation Research. 103, 5, p. 519-26 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Connexins and Pannexins in Cardiovascular Disease
Kwak, B. R. & Nielsen, Morten Schak, 2021, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside. Jalife, J. & Stevenson, W. G. (eds.). 8 ed. Philadelphia, PA, USA: Elsevier, p. 168-177 10 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Phase-2 Re-Entry in Brugada Syndrome: More to Understand Than “Just” Ito
Kanters, Jørgen K. & Nielsen, Morten Schak, 2023, In: JACC: Clinical Electrophysiology. 9, 12, p. 2475-2476Research output: Contribution to journal › Editorial › Research › peer-review
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T-type Ca(2+) channels and Autoregulation of Local Blood Flow
Jensen, Lars Jørn, Nielsen, Morten Schak, Salomonsson, M. & Sorensen, Charlotte Mehlin, 2017, In: Channels (Austin). 11, 3, p. 183-195 13 p.Research output: Contribution to journal › Review › Research › peer-review
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T-type Ca2+ channels and autoregulation of local blood flow
Jensen, Lars Jørn, Nielsen, Morten Schak, Salomonsson, M. & Sorensen, Charlotte Mehlin, 4 May 2017, In: Channels (Austin). 11, 3, p. 183-195Research output: Contribution to journal › Journal article › Research › peer-review
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Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se
Jensen, C. F., Bartels, E. D., Braunstein, T. H., Nielsen, L. B., von Holstein-Rathlou, Niels-Henrik, Axelsen, L. N. & Nielsen, Morten Schak, Apr 2019, In: Physiological Reports. 7, 7, 13 p., e14049.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantification of gap junctional intercellular communication based on digital image analysis
Hofgaard, J. P., Mollerup, S., von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 2009, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 297, 2, p. R243-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes
Hofgaard, J. P., Banach, K., Mollerup, S., Jørgensen, H. K., Olesen, S. P., von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 2008, In: Pflügers Archiv: European Journal of Physiology. 457, 2, p. 303-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress.
Haugan, K., Olsen, Kristine Boisen, Hartvig, L., Petersen, J. S., Hennan, J. K., Nielsen, Morten Schak & von Holstein-Rathlou, Niels-Henrik, 2005, In: Cardiovascular Electrophysiology. 16, 5, p. 537-45 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction.
Haugan, K., Marcussen, N., Kjølbye, A. L., Nielsen, Morten Schak, Hennan, J. K. & Petersen, J. S., 2006, In: Journal of Cardiovascular Pharmacology. 47, 2, p. 236-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels
Hansen, D. B., Ye, Z., Callø, Kirstine, Braunstein, T. H., Hofgaard, J. P., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, 19 Sep 2014, In: The Journal of Biological Chemistry. 289, 38, p. 26058-73 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct permeation profiles of the connexin 30 and 43 hemichannels
Hansen, D. B., Braunstein, T. H., Nielsen, Morten Schak & MacAulay, Nanna, 17 Apr 2014, In: FEBS Letters. 588, 8, p. 1446-57 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The K+ channels of colonic crypts and their regulation
Greger, R., Hamm, K., Warth, R., Nielsen, Morten Schak, Weyand, B., Ecke, D., Riedemann, N., Gerlach, U., Busch, A. E., Englert, H. C., Hropot, M., Lang, H. J. & Bleich, M., 1998, In: Korean Journal of Physiology and Pharmacology. 2, 4, p. 403-409 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels
Gnanasambandam, R., Nielsen, Morten Schak, Nicolai, C., Sachs, F., Hofgaard, J. P. & Dreyer, J. K., 2017, In: Frontiers in Neuroinformatics. 11, 16 p., 31.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts
George, S. A., Hoeker, G., Calhoun, P. J., Entz, M., Raisch, T. B., King, D. R., Khan, M., Baker, C., Gourdie, R. G., Smyth, J. W., Nielsen, Morten Schak & Poelzing, S., 1 Feb 2019, In: American Journal of Physiology: Heart and Circulatory Physiology. 316, 4, p. H849-H861Research output: Contribution to journal › Journal article › Research › peer-review
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Connexins and Disease
Delmar, M., Laird, D. W., Naus, C. C., Nielsen, Morten Schak, Verselis, V. K. & White, T. W., 2018, In: Cold Spring Harbor perspectives in biology. 10, 9, p. 1-18 a029348.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetically modified animals as tools to personalize the study of arrhythmia mechanisms and treatment
Cerrone, M., Nielsen, Morten Schak & Delmar, M., 2018, ESC CardioMed. Camm, A. J., Lüscher, T. F., Maurer, G. & Serruys, P. W. (eds.). 3 ed. Oxford University PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.
Callø, Kirstine, Nielsen, Morten Schak, Grunnet, Morten, Schmitt, Nicole & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling
Bonde, M. M., Olsen, Kristine Boisen, Erikstrup, N., Speerschneider, T., Lyngsø, C., Haunsø, Stig, Nielsen, Morten Schak, Sheikh, S. P. & Hansen, J. L., 2011, In: Regulatory Peptides. 167, 1, p. 21-25 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intracelllular calcium and ADH stimulated sodium transport in frog skin.
Bjerregaard, H., Nielsen, Morten Schak & Brodin, B., 1995, In: Pflügers Archiv: European Journal of Physiology. 430, p. R135 (Abstract)Research output: Contribution to journal › Conference abstract in journal › Research
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Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.
Axelsen, L. N., Haugan, K., Stahlhut, M., Kjølbye, A., Hennan, J. K., Petersen, J. S., Nielsen, Morten Schak & von Holstein-Rathlou, Niels-Henrik, 2007, In: Journal of Membrane Biology. 216, 1, p. 23-35 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Managing the complexity of communication: regulation of gap junctions by post-translational modification
Axelsen, L. N., Callø, Kirstine, von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, Oct 2013, In: Frontiers in Pharmacology. 4, p. 1-18 18 p., 130.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).
Axelsen, L. N., Stahlhut, M., Mohammed, S., Larsen, B. D., Nielsen, Morten Schak, Andersen, S., Jensen, O. N., Hennan, J. K., Kjølbye, A. L. & von Holstein-Rathlou, Niels-Henrik, 2006, In: Journal of Molecular and Cellular Cardiology. 40, 6, p. 790-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis
Axelsen, L. N., Callø, Kirstine, Braunstein, T. H., Riemann, Mads, Hofgaard, J. P., Liang, B., Jensen, C. F., Olsen, Kristine Boisen, Bartels, Emil Daniel, Baandrup, U., Jespersen, Thomas, Nielsen, L. B., von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 14 Jul 2015, In: Cardiovascular Diabetology. 14, 14 p., 87.Research output: Contribution to journal › Journal article › Research › peer-review
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KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.
Angelo, K., Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, S., 2002, In: Biophysical Journal. 83, 4, p. 1997-2006 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isoform-specific phosphorylation-dependent regulation of connexin hemichannels
Alstrøm, J. S., Hansen, D. B., Nielsen, Morten Schak & MacAulay, Nanna, 15 Nov 2015, In: Journal of Neurophysiology. 114, 5, p. 3014-22 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels
Alstrøm, J. S., Stroemlund, L. W., Nielsen, Morten Schak & MacAulay, Nanna, Jun 2015, In: Biochemical Society Transactions. 43, 3, p. 519-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis
Research output: Contribution to journal › Journal article › Research › peer-review
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246
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Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
218
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Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels
Research output: Contribution to journal › Journal article › Research › peer-review
Published