Michael J. Davies
Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- 2006
Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides
Headlam, H. A., Gracanin, M., Rodgers, K. J. & Davies, Michael J., 1 May 2006, In: Free Radical Biology & Medicine. 40, 9, p. 1539-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-acid-mediated damage
Pattison, D. I. & Davies, Michael J., 4 Jul 2006, In: Biochemistry. 45, 26, p. 8152-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of side chains on competing pathways for beta-scission reactions of peptide-backbone alkoxyl radicals
Wood, G. P. F., Easton, C. J., Rauk, A., Davies, Michael J. & Radom, L., 31 Aug 2006, In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. 110, 34, p. 10316-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols
Zeng, J., Dunlop, R. A., Rodgers, K. J. & Davies, Michael J., 1 Sep 2006, In: Biochemical Journal. 398, 2, p. 197-206 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein and low molecular mass thiols as targets and inhibitors of glycation reactions
Zeng, J. & Davies, Michael J., Dec 2006, In: Chemical Research in Toxicology. 19, 12, p. 1668-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diabetes education and self-management for ongoing and newly diagnosed (DESMOND): Process modelling of pilot study
Skinner, Timothy, Carey, M. E., Cradock, S., Daly, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Dec 2006, In: Patient Education and Counseling. 64, 1-3, p. 369-377 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Degradation of extracellular matrix and its components by hypobromous acid
Rees, M. D., McNiven, T. N. & Davies, Michael J., 15 Jan 2007, In: Biochemical Journal. 401, 2, p. 587-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages
Brown, B. E., Rashid, I., van Reyk, D. M. & Davies, Michael J., Mar 2007, In: F E B S Journal. 274, 6, p. 1530-41 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin: cholesterol acyltransferase
Nobecourt, E., Davies, Michael J., Brown, B. E., Curtiss, L. K., Bonnet, D. J., Charlton, F., Januszewski, A. S., Jenkins, A. J., Barter, P. J. & Rye, K. -., Mar 2007, In: Diabetologia. 50, 3, p. 643-653 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro
Rashid, I., van Reyk, D. M. & Davies, Michael J., 6 Mar 2007, In: FEBS Letters. 581, 5, p. 1067-70 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism
Kennett, E. C. & Davies, Michael J., 15 Apr 2007, In: Free Radical Biology & Medicine. 42, 8, p. 1278-89 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products
Gracanin, M. & Davies, Michael J., 15 May 2007, In: Free Radical Biology & Medicine. 42, 10, p. 1543-51 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses
Parker, N. R., Korlimbinis, A., Jamie, J. F., Davies, Michael J. & Truscott, R. J. W., Aug 2007, In: Investigative Ophthalmology & Visual Science. 48, 8, p. 3705-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?
Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 28 Aug 2007, In: Biochemistry. 46, 34, p. 9853-64 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides
Dremina, E. S., Sharov, V. S., Davies, Michael J. & Schöneich, C., Oct 2007, In: Chemical Research in Toxicology. 20, 10, p. 1462-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants
Skaff, O., Pattison, D. I. & Davies, Michael J., Dec 2007, In: Chemical Research in Toxicology. 20, 12, p. 1980-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis
Morgan, P. E., Sturgess, A. D., Hennessy, A. & Davies, Michael J., Dec 2007, In: Free Radical Research. 41, 12, p. 1301-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links
Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael J., 2008, In: Biochemical Journal. 410, 3, p. 565-574Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cluster randomised controlled trial
Davies, Michael J., Heller, S., Skinner, Timothy, Campbell, M. J., Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Doherty, Y., Eaton, S., Fox, C., Oliver, L., Rantell, K., Rayman, G. & Khunti, K., 1 Mar 2008, In: BMJ. 336, 7642, p. 491-495 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The DESMOND educational intervention
Davies, Michael J., Heller, S., Khunti, K. & Skinner, Timothy, 1 Mar 2008, In: Chronic Illness. 4, 1, p. 38-40 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
Mizdrak, J., Hains, P. G., Truscott, R. J. W., Jamie, J. F. & Davies, Michael J., 15 Mar 2008, In: Free Radical Biology & Medicine. 44, 6, p. 1108-19 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation
Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M. J. A. P., Bannon, P. G., Waltenberger, J. & Davies, Michael J., May 2008, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 5, p. 1024-30 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I
Nobecourt, E., Zeng, J., Davies, Michael J., Brown, B. E., Yadav, S., Barter, P. J. & Rye, K. -., Jun 2008, In: Diabetologia. 51, 6, p. 1008-1017 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Oxidative damage to extracellular matrix and its role in human pathologies
Rees, M. D., Kennett, E. C., Whitelock, J. M. & Davies, Michael J., 15 Jun 2008, In: Free Radical Biology & Medicine. 44, 12, p. 1973-2001 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mammalian heme peroxidases: from molecular mechanisms to health implications
Davies, Michael J., Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Waiting for diabetes: Perceptions of people with pre-diabetes: A qualitative study
Troughton, J., Jarvis, J., Skinner, Timothy, Robertson, N., Khunti, K. & Davies, Michael J., 1 Jul 2008, In: Patient Education and Counseling. 72, 1, p. 88-93 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study
Skaff, O., Pattison, D. I. & Davies, Michael J., 5 Aug 2008, In: Biochemistry. 47, 31, p. 8237-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines
Summers, F. A., Morgan, P. E., Davies, Michael J. & Hawkins, Clare Louise, Sep 2008, In: Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
'Educator talk' and patient change: Some insights from the DESMOND (Diabetes Education and Self Management for Ongoing and Newly Diagnosed) randomized controlled trial
Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Sep 2008, In: Diabetic Medicine. 25, 9, p. 1117-1120 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid
Kennett, E. C. & Davies, Michael J., 1 Sep 2008, In: Free Radical Biology & Medicine. 45, 5, p. 716-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
Lloyd, M. M., van Reyk, D. M., Davies, Michael J. & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin
Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael J. & Witting, P. K., 15 Sep 2008, In: Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals
Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins
Morgan, P. E., Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2008, In: Free Radical Biology & Medicine. 45, 9, p. 1279-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes: Baseline data from the DESMOND randomized controlled trial
Khunti, K., Skinner, Timothy, Heller, S., Carey, M. E., Dallosso, H. M. & Davies, Michael J., 1 Dec 2008, In: Diabetic Medicine. 25, 12, p. 1454-1461 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation
Hawkins, Clare Louise, Pattison, D. I., Stanley, N. R. & Davies, Michael J., 15 Dec 2008, In: Biochemical Journal. 416, 3, p. 441-52 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients
Morgan, P. E., Sturgess, A. D. & Davies, Michael J., Feb 2009, In: Free Radical Research. 43, 2, p. 117-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypobromous acid and bromamine production by neutrophils and modulation by superoxide
Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J. & Davies, Michael J., 1 Feb 2009, In: Biochemical Journal. 417, 3, p. 773-81 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Quantification of protein modification by oxidants
Hawkins, Clare Louise, Morgan, P. E. & Davies, Michael J., 15 Apr 2009, In: Free Radical Biology & Medicine. 46, 8, p. 965-88 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach
Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., May 2009, In: Chemical Research in Toxicology. 22, 5, p. 807-17 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides
Rees, M. D., Bottle, S. E., Fairfull-Smith, K. E., Malle, E., Whitelock, J. M. & Davies, Michael J., 1 Jul 2009, In: Biochemical Journal. 421, 1, p. 79-86 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products
Gracanin, M., Hawkins, Clare Louise, Pattison, D. I. & Davies, Michael J., 1 Jul 2009, In: Free Radical Biology & Medicine. 47, 1, p. 92-102 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation
Kennett, E. C. & Davies, Michael J., 15 Aug 2009, In: Free Radical Biology & Medicine. 47, 4, p. 389-400 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance
Skaff, O., Pattison, D. I. & Davies, Michael J., 15 Aug 2009, In: Biochemical Journal. 422, 1, p. 111-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prevalence of depression in White-European and South-Asian people with impaired glucose regulation and screen-detected type 2 diabetes mellitus
Aujla, N., Abrams, K. R., Davies, Michael J., Taub, N., Skinner, Timothy & Khunti, K., 9 Nov 2009, In: PLoS ONE. 4, 11, e7755.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy
Sourris, K. C., Harcourt, B. E., Penfold, S. A., Yap, F. Y. T., Morley, A. L., Morgan, P. E., Davies, Michael J., Baker, S. T., Jerums, G. & Forbes, J. M., 2010, In: Journal of Diabetes Research. 2010, p. 974681Research output: Contribution to journal › Journal article › Research › peer-review
Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan
Rees, M. D., Whitelock, J. M., Malle, E., Chuang, Christine, Iozzo, R. V., Nilasaroya, A. & Davies, Michael J., Jan 2010, In: Matrix Biology. 29, 1, p. 63-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction
Szuchman-Sapir, A. J., Pattison, D. I., Davies, Michael J. & Witting, P. K., 1 Jan 2010, In: Free Radical Biology & Medicine. 48, 1, p. 35-46 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association between depression and health-related quality of life in people with type 2 diabetes: A systematic literature review
Ali, S., Stone, M., Skinner, Timothy, Robertson, N., Davies, Michael J. & Khunti, K., 1 Feb 2010, In: Diabetes/Metabolism Research and Reviews. 26, 2, p. 75-89 15 p.Research output: Contribution to journal › Review › Research › peer-review
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I
Nobécourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, Michael J., Brown, B. E., Jenkins, A. J., Dusting, G. J., Bonnet, D. J., Curtiss, L. K., Barter, P. J. & Rye, K., Apr 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 4, p. 766-72 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 38036205
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Protein oxidation and peroxidation
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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
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Cardiac spheroids as promising in vitro models to study the human heart microenvironment
Research output: Contribution to journal › Journal article › Research › peer-review
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