Mette Rosenkilde
Professor
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
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Probing Biased Signaling in Chemokine Receptors
Amarandi, R. M., Hjortø, Gertrud Malene, Rosenkilde, Mette & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Ligand-selective small molecule modulators of the constitutively active vGPCR US28
Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics of high-dose intravenous melatonin in humans
Andersen, Lars Peter Kloster, Werner, M. U., Rosenkilde, Mette, Fenger, A. Q., Petersen, M. C., Rosenberg, Jacob & Gögenur, Ismail, Mar 2016, In: Journal of Clinical Pharmacology. 56, 3, p. 324-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
Andersen, Lars Peter Kloster, Werner, M. U., Rosenkilde, Mette, Harpsøe, N. G., Fuglsang, H., Rosenberg, Jacob & Gögenur, Ismail, 2016, In: BMC Pharmacology and Toxicology. 17, p. 1-5 5 p., 8.Research output: Contribution to journal › Journal article › Research › peer-review
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Signaling via G proteins mediates tumorigenic effects of GPR87
Arfelt, K. N., Fares, S., wbf943, wbf943, Hjortø, Gertrud Malene, Gasbjerg, Lærke Smidt, Molleskov-Jensen, A., Benned-Jensen, T. & Rosenkilde, Mette, Jan 2017, In: Cellular Signalling. 30, p. 9-18Research output: Contribution to journal › Journal article › Research › peer-review
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EBV, the Human Host, and the 7TM Receptors: Defense or Offense?
Arfelt, K. N., Fares, S. & Rosenkilde, Mette, 2015, The Molecular Basis of Viral Infection. Klasse, P. J. (ed.). Academic Press, Vol. 129. p. 395-427 (Progress in Molecular Biology and Translational Science, Vol. 129).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119
Arifin, S. A., Paternoster, S., Carlessi, R., Casari, I., Ekberg, J. H., Maffucci, T., Newsholme, P., Rosenkilde, Mette & Falasca, M., 2018, In: B B A - Molecular and Cell Biology of Lipids. 1863, 9, p. 1132-1141Research output: Contribution to journal › Journal article › Research › peer-review
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The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor
Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats
Baidassano, S., Gasbjerg, Lærke Smidt, Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Holst, Jens Juul & Hartmann, Bolette, 2019, In: Frontiers in Endocrinology. 10, 11 p., 492.Research output: Contribution to journal › Journal article › Research › peer-review
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EBI2 in splenic and local immune responses and in autoimmunity
Barington, L., Wanke, F., Niss Arfelt, K., Holst, Peter Johannes, Kurschus, F. C. & Rosenkilde, Mette, 2018, In: Journal of Leukocyte Biology. 104, 2, p. 313-322 10 p.Research output: Contribution to journal › Review › Research › peer-review
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GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity
Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding
Barington, L., Rummel, P. C., Lückmann, Michael, Pihl, H., Larsen, Olav, Daugvilaite, V., Johnsen, A. H., Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 19 May 2016, In: The Journal of Biological Chemistry. 291, 31, p. 16208-16220Research output: Contribution to journal › Journal article › Research › peer-review
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GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Bartlett, S., Gemiarto, A. T., Ngo, M. D., Sajiir, H., Hailu, S., Sinha, R., Foo, C. X., Kleynhans, L., Tshivhula, H., Webber, T., Bielefeldt-Ohmann, H., West, N. P., Hiemstra, A. M., MacDonald, C. E., Christensen, Liv von Voss, Schlesinger, L. S., Walzl, G., Rosenkilde, Mette, Mandrup-Poulsen, Thomas & Ronacher, K., 2020, In: Frontiers in Immunology. 11, 11 p., 601534.Research output: Contribution to journal › Journal article › Research › peer-review
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Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells
Bauer, A., Madela, J., Berg, Christian, Daugvilaite, V., Gurka, S., Mages, H. W., Kroczek, R. A., Rosenkilde, Mette & Voigt, S., 2020, In: Journal of Cell Science. 133, 5, 11 p., jcs236190.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Baumann, M., Hussain, M. M., Henne, N., Garrote, D. M., Karlshoj, S., Fossen, T., Rosenkilde, Mette, Vabeno, J. & Haug, B. E., 15 Jan 2017, In: Bioorganic & Medicinal Chemistry. 25, 2, p. 646-657Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism
Baumann, M., Nome, L. M., Zachariassen, Z. G., Karlshoj, S., Fossen, T., Rosenkilde, Mette, Vabeno, J. & Haug, B. E., 2017, In: Tetrahedron. 73, 27-28, p. 3866-3877Research output: Contribution to journal › Journal article › Research › peer-review
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Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation
Benned-Jensen, T., Madsen, C. M., Arfelt, K. N., Smethurts, C., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 2013, In: FEBS Open Bio. 3, p. 156-60 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of transmembrane segment II in 7TM receptor activation
Benned-Jensen, T. & Rosenkilde, Mette, Jun 2009, In: Current Molecular Pharmacology. 2, 2, p. 140-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling
Benned-Jensen, T., Mokrosinski, J. & Rosenkilde, Mette, 2011, In: P L o S One. 6, 9, p. e24644Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)
Benned-Jensen, T., Norn, C., Laurent, S., Madsen, C. M., Larsen, H. M., Arfelt, K. N., Wolf, R. M., Frimurer, Thomas Michael, Sailer, A. W. & Rosenkilde, Mette, 12 Oct 2012, In: The Journal of Biological Chemistry. 287, 42, p. 35470-83 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist
Benned-Jensen, T. & Rosenkilde, Mette, 2008, In: Molecular Pharmacology. 74, 4, p. 1008-21 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST
Benned-Jensen, T., Smethurst, C., Holst, Peter Johannes, Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, Thue W., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4
Berg, Christian, Daugvilaite, V., Steen, A., Jørgensen, Astrid Sissel, Våbenø, J. & Rosenkilde, Mette, 20 Apr 2018, In: ACS chemical biology. 13, 4, p. 881-886 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges
Berg, Christian & Rosenkilde, Mette, 2023, In: Frontiers in Immunology. 14, 8 p., 1135280.Research output: Contribution to journal › Review › Research › peer-review
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Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5
Berg, Christian, Spiess, Katja, von Lüttichau, H. R. & Rosenkilde, Mette, Dec 2016, In: Pharmacology Research & Perspectives. 4, 6, 14 p., e00262.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
Berg, Christian, Friis, M. B., Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Lüttichau, H. R. & Sundelin, T., 2019, In: PLoS ONE. 14, 9, 14 p., e0222053.Research output: Contribution to journal › Journal article › Research › peer-review
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The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population
Berg, Christian, Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Sundelin, T. & Luttichau, H. R., 2021, In: BMC Infectious Diseases. 21, 1, 12 p., 386.Research output: Contribution to journal › Journal article › Research › peer-review
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The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-Terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist
Berg, Christian, Wedemeyer, M. J., Melynis, M., Schlimgen, R. R., Hansen, L. H., Vabenø, J., Peterson, F. C., Volkman, B. F., Rosenkilde, Mette & Lüttichau, H. R., 2022, In: PLOS Pathogens. 18, 3, e1010355.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice
Boer, G. A., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Sparre-Ulrich, A. H., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4486-4499Research output: Contribution to journal › Journal article › Research › peer-review
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Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails
Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.Research output: Contribution to journal › Journal article › Research › peer-review
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G protein-coupled receptor pharmacology-The next generation
Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.Research output: Contribution to journal › Editorial › Research
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Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer
Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, Mette, Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2018, In: Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631Research output: Contribution to journal › Journal article › Research › peer-review
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Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo
Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, Mette, Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators
Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
Christensen, M., wbf943, wbf943, Hartmann, Bolette, Grevstad, U., Rosenkilde, Mette, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Nov 2015, In: International journal of obesity (2005). 39, 11, p. 1651-1654 4 p.Research output: Contribution to journal › Letter › Research › peer-review
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Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes
Christensen, Mikkel Bring, Calanna, S., wbf943, wbf943, Kristensen, P. L., Rosenkilde, Mette, Faber, Jens, Purrello, F., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Jan 2015, In: Diabetes. 64, 1, p. 72-78 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon
Christiansen, Charlotte Bayer, Gabe, M. B. N., Svendsen, B., Dragsted, Lars Ove, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 315, 1, p. G53-G65 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling
Conceição, F., Sousa, D. M., Tojal, S., Lourenço, C., Carvalho-Maia, C., Estevão-Pereira, H., Lobo, J., Couto, M., Rosenkilde, Mette, Jerónimo, C. & Lamghari, M., 2023, In: Biomolecules. 13, 4, 25 p., 622.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2
Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042Research output: Contribution to journal › Journal article › Research › peer-review
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Oxysterol-EBI2 signaling in immune regulation and viral infection
Daugvilaite, V., Arfelt, K. N., Benned-Jensen, T., Sailer, A. W. & Rosenkilde, Mette, Jul 2014, In: European Journal of Immunology. 44, 7, p. 1904-12 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of potent and proteolytically stable human neuromedin U receptor agonists
De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75Research output: Contribution to journal › Journal article › Research › peer-review
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Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
Dillemans, L., Yu, K., De Zutter, A., Noppen, S., Gouwy, M., Berghmans, N., Verhallen, L., De Bondt, M., Vanbrabant, L., Brusselmans, S., Martens, E., Schols, D., Verschueren, P., Rosenkilde, Mette, Marques, P. E., Struyf, S. & Proost, P., 2024, In: Cell Communication and Signaling. 22, 1, 23 p., 94.Research output: Contribution to journal › Journal article › Research › peer-review
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The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies
Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial
Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, Jacob, Jonsson, G., Aarøe, J., Gasbjerg, Lærke Smidt, Rosenkilde, Mette & Gögenur, Ismail, Dec 2017, In: Journal of Cardiovascular Translational Research. 10, 5-6, p. 470-479 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2
Ewart, G., Bobardt, M., Bentzen, Bo Hjorth, Yan, Y., Thomson, A., Klumpp, K., Becker, S., Rosenkilde, Mette, Miller, M. & Gallay, P., 2023, In: PLoS Pathogens. 19, 8 August, 20 p., e1011328.Research output: Contribution to journal › Journal article › Research › peer-review
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Re-routing GPR56 signalling using Gα12/13 G protein chimeras
Faas, Felix, Nørskov, Amalie, Holst, Peter Johannes, Andersson, A. M., Qvortrup, K., Mathiasen, Signe & Rosenkilde, Mette, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 378-389Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation
Fares, S., Spiess, Katja, Olesen, Emma Tina Bisgaard, Zuo, J., Jackson, S., Kledal, T. N., Wills, M. R. & Rosenkilde, Mette, 2019, In: mBio. 10, 1, e01707-18.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model
Farrell, H. E., Abraham, A. M., Cardin, R. D., Mølleskov-Jensen, A., Rosenkilde, Mette & Davis-Poynter, N., Apr 2013, In: Journal of Virology. 87, 7, p. 4112-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues
Farrell, H. E., Abraham, A. M., Cardin, R. D., wbf943, wbf943, Rosenkilde, Mette, Spiess, Katja, Jensen, T. H., Kledal, T. N. & Davis-Poynter, N., Jun 2011, In: Journal of Virology. 85, 12, p. 6091-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection
Foo, C. X., Bartlett, S., Chew, K. Y., Ngo, M. D., Bielefeldt-Ohmann, H., Arachchige, B. J., Matthews, B., Reed, S., Wang, R., Smith, C., Sweet, M. J., Burr, L., Bisht, K., Shatunova, S., Sinclair, J. E., Parry, R., Yang, Y., Lévesque, J. P., Khromykh, A., Rosenkilde, M. M. & 2 others, , 2023, In: The European respiratory journal. 61, 3, 15 p., 2201306.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1
Fox, J. C., Thomas, M. A., Dishman, A. F., Larsen, Olav, Nakayama, T., Yoshie, O., Rosenkilde, Mette & Volkman, B. F., 2019, In: Science Signaling. 12, 597, 15 p., eaat4128.Research output: Contribution to journal › Journal article › Research › peer-review
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Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28
Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review
Gabe, M. B. N., van der Velden, W. J. C., Smit, F. X., Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2020, In: Peptides. 125, 8 p., 170224.Research output: Contribution to journal › Review › Research › peer-review
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Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system
Gabe, M. B. N., van der Velden, W. J. C., Gadgaard, S., Smit, F. X., Hartmann, Bolette, Bräuner, Hans & Rosenkilde, Mette, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 122-132Research output: Contribution to journal › Journal article › Research › peer-review
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Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice
Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction
Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485Research output: Contribution to journal › Journal article › Research › peer-review
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Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system
Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose and Amino Acid Metabolism in Mice Depend Mutually on Glucagon and Insulin Receptor Signaling
Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Rosenkilde, Mette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E660-E673Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2
Gasbjerg, Lærke Smidt, Hartmann, Bolette, Christensen, Mikkel Bring, Lanng, A. R., Vilsbøll, Tina, Jørgensen, Niklas Rye, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 130, 6 p., 115079 .Research output: Contribution to journal › Journal article › Research › peer-review
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Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans
Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74Research output: Contribution to journal › Journal article › Research › peer-review
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GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Hartmann, Bolette, Lanng, A. R., wbf943, wbf943, Gabe, M. B. N., Dela, Flemming, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, Feb 2018, In: Diabetologia. 61, 2, p. 413-423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, Jensen, M. H., Gabe, M. B. N., wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2019, In: Diabetes. 68, 3, p. 906-917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e725-e738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.Research output: Contribution to journal › Review › Research › peer-review
- Published
The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide
Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
Gasbjerg, Lærke Smidt, Gabe, M. B. N., Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Feb 2018, In: Peptides. 100, p. 173-181Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor
Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor
Gessier, F., Preuss, I., Yin, H., Rosenkilde, Mette, Laurent, S., Endres, R., Chen, Y. A., Marsilje, T. H., Seuwen, K., Nguyen, D. G. & Sailer, A. W., 24 Apr 2014, In: Journal of Medicinal Chemistry. 57, 8, p. 3358-68 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice
Gobron, B., Bouvard, B., Vyavahare, S., Blom, L. V. V., Pedersen, K. K., Windeløv, Johanne Agerlin, Boer, G. A., Harada, N., Zhang, S., Shimazu-Kuwahara, S., Wice, B., Inagaki, N., Legrand, E., Flatt, P. R., Chappard, D., Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette, Irwin, N. & Mabilleau, G., 2020, In: Journal of Bone and Mineral Research. 35, 7, p. 1363-1374 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration
González-Motos, V., Jürgens, C., Ritter, B., Kropp, K. A., Durán, V., Larsen, Olav, Binz, A., Ouwendijk, W. J. D., Lenac Rovis, T., Jonjic, S., Verjans, G. M. G. M., Sodeik, B., Krey, T., Bauerfeind, R., Schulz, T. F., Kaufer, B. B., Kalinke, U., Proudfoot, A. E. I., Rosenkilde, Mette & Viejo-Borbolla, A., May 2017, In: PLOS Pathogens. 13, 5, 28 p., e1006346.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications
Goth, C. K., Petaja-Repo, U. E. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 237-245Research output: Contribution to journal › Review › Research › peer-review
- Published
Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats
Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031Research output: Contribution to journal › Journal article › Research › peer-review
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High content screening for G protein-coupled receptors using cell-based protein translocation assays
Grånäs, C., Lundholt, B. K., Heydorn, A., Linde, V., Pedersen, H., Krog-Jensen, C., Rosenkilde, Mette & Pagliaro, L., 2005, In: Combinatorial Chemistry & High Throughput Screening. 8, 4, p. 301-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR119 as a fat sensor
Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Treatment of insulin resistance and obesity by stimulating GLP-1 release
Hansen, Harald S., Diep, T. A., Holst, Jens Juul, Rosenkilde, Mette & Andersen, N. W., 29 Dec 2010, IPC No. A61K 31/23, Patent No. PCT/DK2010/050161, 24 Jun 2010Research output: Patent
- Published
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N- and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor
Hansen, L. S., wbf943, wbf943, Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 826-838 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists
Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21
Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells
Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor
Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor
Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry
Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis
Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction
Heydorn, A., Ward, R. J., Jorgensen, R., Rosenkilde, Mette, Frimurer, T. M., Milligan, G. & Kostenis, E., 2004, In: Molecular Pharmacology. Vol. 66, no. 2, p. 250-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery
Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery
Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications
Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent advances of GIP and future horizons
Holst, Jens Juul & Rosenkilde, Mette, 2020, In: Peptides. 125, 6 p., 170230.Research output: Contribution to journal › Review › Research › peer-review
- Published
The role of incretins on insulin function and glucose homeostasis
Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.Research output: Contribution to journal › Review › Research › peer-review
- Published
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity
Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virally encoded chemokines and chemokine receptors in the role of viral infections
Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
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