Mette Rosenkilde
Professor
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Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium
Petersen, N., Pedersen, Lola Julie Torz, Jensen, Kristian HR, Hjortø, Gertrud Malene, Spiess, Katja & Rosenkilde, Mette, 2020, In: Frontiers in Cellular Neuroscience. 14, 11 p., 108.Research output: Contribution to journal › Journal article › Research › peer-review
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Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects
Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, Cathrine, Rosenkilde, Mette, Hartmann, B. & Holst, Jens Juul, 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vasopressin receptors V1a and V2 are not osmosensors
Pedersen, K. L., Assentoft, M., Fenton, R. A., Rosenkilde, Mette & MacAulay, Nanna, Aug 2015, In: Physiological Reports. 3, 8, 11 p., e12519.Research output: Contribution to journal › Journal article › Research › peer-review
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The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine
Pedersen, Jens, B. Pedersen, N., Brix, S. W., Grunddal, Kaare Villum, Rosenkilde, Mette, Hartmann, Bolette, Ørskov, Cathrine, Poulsen, Steen Seier & Holst, Jens Juul, May 2015, In: Peptides. 67, p. 20-28 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats
Pedersen, C., Bouman, S. D., Porsgaard, T., Rosenkilde, Mette & Roed, N. K., 2018, In: Physiological Reports. 6, 6, 9 p., e13657 .Research output: Contribution to journal › Journal article › Research › peer-review
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Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats
Pedersen, C., Porsgaard, T., Thomsen, M., Rosenkilde, Mette & Roed, N. K., 2018, In: PLoS ONE. 13, 3, 17 p., .0194468.Research output: Contribution to journal › Journal article › Research › peer-review
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Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor
Paulsen, S. J., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor
Paulsen, S., Rosenkilde, Mette, Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics
Paternoster, S., Simpson, P. V., Kokh, E., Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Mancera, R. L., Keating, D. J., Massi, M. & Falasca, M., 2021, In: Pharmacological Research. 172, 105822.Research output: Contribution to journal › Journal article › Research › peer-review
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The Gβγ-subunit interacts directly with aquaporin-2 (AQP2) and regulates its membrane targeting
Olesen, Emma Tina Bisgaard, Poulsen, S. B., Rosenkilde, Mette, Sorensen, Charlotte Mehlin & Fenton, R. A., 2018.Research output: Contribution to conference › Conference abstract for conference › Research
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EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
Nørregaard, K., Benned-Jensen, T. & Rosenkilde, Mette, 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand binding and micro-switches in 7TM receptor structures
Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice
Nybo, Maja Lind, Kvam, J. M., Nielsen, J. E., Frederiksen, H., Spiess, Katja, Jensen, Kristian HR, Gadgaard, S., Walser, Anna Louise Silvia, Thomsen, J. S., Cowin, P., Juul, Anders, Jensen, M. B. & Rosenkilde, Mette, 2023, In: FASEB Journal. 37, 2, 13 p., 22781.Research output: Contribution to journal › Journal article › Research › peer-review
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EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies
Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878Research output: Contribution to journal › Journal article › Research › peer-review
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A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection
Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?
Mølleskov-Jensen, A., wbf943, wbf943, Davis-Poynter, N. & Rosenkilde, Mette, 2012, In: Advances in Virology. 2012, p. 231813Research output: Contribution to journal › Journal article › Research › peer-review
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Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4)
Mungalpara, J., Thiele, S., Eriksen, Ø., Eksteen, J., Rosenkilde, Mette & Våbenø, J., 9 Oct 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10287-10291 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists
Mungalpara, J., Zachariassen, Z. G., Thiele, S., Rosenkilde, Mette & Våbenø, J., 21 Dec 2013, In: Organic & Biomolecular Chemistry. 11, 47, p. 8202-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21
Moussouras, N. A., Hjortø, Gertrud Malene, Peterson, F. C., Szpakowska, M., Chevigné, A., Rosenkilde, Mette, Volkman, B. F. & Dwinell, M. B., 7 Apr 2020, In: Biochemistry. 59, 13, p. 1338-1350 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms
Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .Research output: Contribution to journal › Journal article › Research › peer-review
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Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes
Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74
McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation
Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.Research output: Contribution to journal › Journal article › Research › peer-review
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Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality
Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.Research output: Contribution to journal › Journal article › Research › peer-review
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Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Mavri, M., Glišić, S., Senćanski, M., Vrecl, M., Rosenkilde, Mette, Spiess, Katja & Kubale, V., 2023, In: Cellular and Molecular Biology Letters. 28, 1, 19 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
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Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors
Mavri, M., Spiess, Katja, Rosenkilde, Mette, Rutland, C. S., Vrecl, M. & Kubale, V., 2020, In: Molecules. 25, 23, 23 p., 5710.Research output: Contribution to journal › Review › Research › peer-review
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The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease
Maskery, M., Goulding, E. M., Gengler, S., Melchiorsen, J. U., Rosenkilde, Mette & Holscher, C., 2020, In: American Journal of Alzheimer's Disease and Other Dementias. 35, 11 p., 1533317520953041.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.Research output: Contribution to journal › Journal article › Research › peer-review
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An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Madsen, Thomas Daugbjerg, Hansen, L. H., Hintze, John, Ye, Z., Jebari, S., Andersen, Daniel Bjørklund, Joshi, Hiren Jitendra, Ju, T., Goetze, Jens P. , Martin, C., Rosenkilde, Mette, Holst, Jens Juul, Kuhre, Rune Ehrenreich, Goth, C. K., Vakhrushev, Sergey & Schjoldager, Katrine Ter-Borch Gram, 2020, In: Nature Communications. 11, 1, 13 p., 4033.Research output: Contribution to journal › Journal article › Research › peer-review
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Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3
Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-based discovery of novel US28 small molecule ligands with different modes of action
Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296Research output: Contribution to journal › Journal article › Research › peer-review
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GPR162 is a beta cell CART receptor
Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.Research output: Contribution to journal › Journal article › Research › peer-review
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The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection
Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1
Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.Research output: Contribution to journal › Letter › Research › peer-review
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Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of a conserved chemokine receptor motif that enables ligand discrimination
Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.Research output: Contribution to journal › Journal article › Research › peer-review
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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
Krishna, B. A., Spiess, Katja, Poole, E. L., Lau, B., Voigt, S., Kledal, T. N., Rosenkilde, Mette & Sinclair, J. H., 2 Feb 2017, In: Nature Communications. 8, 14321.Research output: Contribution to journal › Journal article › Research › peer-review
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A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity
Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, Mette, Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular properties and therapeutic targeting of the ebv-encoded receptor bilf1
Knerr, J. M., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Cancers. 13, 16, 26 p., 4079.Research output: Contribution to journal › Review › Research › peer-review
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A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus
Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659Research output: Contribution to journal › Journal article › Research › peer-review
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Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28
Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214Research output: Contribution to journal › Journal article › Research › peer-review
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CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection
Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand entry pathways control the chemical space recognized by GPR183
Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683Research output: Contribution to journal › Journal article › Research › peer-review
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Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Stepniewski, T. M., Madsen, C. M., Jørgensen, Astrid Sissel, Bhuskute, K. R., Inoue, A., Ulven, Trond, Benned-Jensen, T., Hjorth, Siv Annegrethe, Hjortø, Gertrud Malene, Moo, Ee Von, Selent, J. & Rosenkilde, Mette, 2023, In: Science Signaling. 16, 779, 13 p., eabl4283.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 3361
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Pharmacokinetics of oral and intravenous melatonin in healthy volunteers
Research output: Contribution to journal › Journal article › Research › peer-review
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442
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Research output: Contribution to journal › Journal article › Research › peer-review
Published