Martin Gustavsson

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G protein-coupled receptors (GPCRs) relay signals from the outside to the inside of the cell by coupling to G proteins and other intracellular mediators. GPCRs are the targets of around 30% of approved drugs and development of new and therapies is a major focus of academic groups and companies worldwide. In the Gustavsson group, we aim to understand the molecular details of receptor function and regulation and translate our findings to receptor physiology.

We combine characterization of receptor pharmacology in cells and reconstituted systems with characterization of receptor structure and dynamics. Our key methods are:

• Protein expression and purification in prokaryotic and eukaryotic systems
• Functional characterization by binding and signaling assays (BRET, FRET, radioligand binding, SPR etc)
• Receptor structure and dynamics (cryo-EM, NMR, FRET etc.)

Read more about the Gustavsson Group by clicking here

 

Primary fields of research

• Structural biology
• Receptor pharmacology and signaling
• G protein-coupled receptors
• Chemokine receptors