Helge Group – Integrative Exercise Physiology

Whole body

• Body composition Dual-Energy X-ray Absorptiometry (DEXA scan)
• Fat oxidation at rest and during exercise (Maximal fat oxidation)
• Maximal oxygen uptake VO_2max (bike, treadmill, skiing ergometer)
• Assessment of VO_2max using a medical device Seismofit (Ventriject A/S)
• Assessment of endurance capacity (yo-Yo tests, treadmill, etc.)

Tissue analysis

• Muscle biopsies (substrates, enzymes, lipidomics)
• Mitochondrial function (collaboration with Assoc. prof. Steen Larsen)
• Adipose tissue biopsies (inflammation & macrophages)
• Blood analysis (FFA, Ketones, Catecholamines, etc.)

In analysis

• Effects of 84 hours fasting on muscle and blood lipidomic profile in young and old men
• Effects of training on
  1) adipose tissue and low-grade inflammation
  2) plasma and muscle tissue lipidomics in matched obese and T2D individuals.
• Variation of maximal fat oxidation in upper/lower/and combined exercise in normal trained or upper body trained athletes.
• Influence of BMI and age on adipose tissue extracellular matrix.

In process

• Effects of 84 hours fasting on MFO and Mitochondrial coupling in men and women, both normal weight and obese
• Evaluation of Seismofit- estimation of VO_2max in patients with knee arthritis before and after training
• Two supplementary groups
  1) young women with training induced secondary amenoré and
  2) Obese trained young women are being recruited to complement a large study done in women focusing on the influence on MFO.
• The influence of hypoxia on MFO.

• Assoc. Prof. Steen Larsen, Dept of Biomedical Science, UCPH.
• Professor Nils Færgeman, University of Southern Denmark, Odense.
• Assoc. Prof. Chris Shaw, University of Deakin, Geelong, Victoria, Australia.
• Assoc. Prof. Christoffer Clemmensen, Center of Basic Metabolism, UCPH.
• Assoc. Prof. Katrine Schjoldager, Dept Cellular and Molecular Medicine, UCPH.
• Professor Peter Meikle, Baker Heart and Diabetes Institute, Melbourne, Australia.
• Professor Mette Hansen, Centre of Sports Science, Aarhus University, Aarhus,
• Professor Rob Boushel, University of British Columbia, Canada.
• Professor Jose Calbet, University of Las Palmas, Las Palmas, Spain.
• Professor Paul Greenhaff, University of Nottingham, Nottingham, UK.
• Professor Samuel E Schmidt, Ålborg Universitet.
• Professor Ignacio Ara Royo, University Castilla la Mancha, Toledo.
• Professor Christina Blasco-Lafarga, University of Valencia, Valencia, Spain.

I collaborate with the Danish Biotech company Ventriject A/S, and have until 2025 had a collaborative project Grant with Novo Nordisk A/S.

Current running Grants

• SUND Collaborates (Internal UCPH funding)
• Ventriject A/S
• Per Henriksens Fond

Ongoing projects from former grants

• Novo Nordisk A/S
• Carlsberg Fonden