Michael Jonathan Davies

Michael Jonathan Davies

Professor

ORCID: 0000-0002-5196-6919

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  1. Published

    beta-Scission of C-3 (beta-carbon) alkoxyl radicals on peptides and proteins: a novel pathway which results in the formation of alpha-carbon radicals and the loss of amino acid side chains

    Headlam, H. A., Mortimer, A., Easton, C. J. & Davies, Michael Jonathan, Nov 2000, In: Chemical Research in Toxicology. 13, 11, p. 1087-95 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    alpha- and beta-casein aggregation induced by riboflavin-sensitized photo-oxidation occurs via di-tyrosine cross-links and is oxygen concentration dependent

    Fuentes-Lemus, E., Silva, E., Leinisch, F., Dorta, E., Lorentzen, L. G., Davies, Michael Jonathan & Lopez-Alarcon, C., 1 Aug 2018, In: Food Chemistry. 256, p. 119-128

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Xanthine oxidase activity and free radical generation in patients with sepsis syndrome

    Galley, H. F., Davies, Michael Jonathan & Webster, N. R., 1996, In: Critical Care Medicine. 24, 10, p. 1649-53 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Whey proteins: targets of oxidation, or mediators of redox protection

    Giblin, L., Yalcin, A. S., Bicim, G., Krämer, Anna Carola, Chen, Z., Callanan, M. J., Arranz, E. & Davies, Michael Jonathan, 2019, In: Free Radical Research. 53, S1, p. 1136–1152 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, May 2009, In: Chemical Research in Toxicology. 22, 5, p. 807-17 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Waiting for diabetes: Perceptions of people with pre-diabetes: A qualitative study

    Troughton, J., Jarvis, J., Skinner, Timothy, Robertson, N., Khunti, K. & Davies, Michael Jonathan, 1 Jul 2008, In: Patient Education and Counseling. 72, 1, p. 88-93 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications

    Rykær, M., Svensson, B., Davies, Michael Jonathan & Hägglund, Per Mårten, 3 Nov 2017, In: Journal of Proteome Research. 16, 11, p. 3978-3988 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Unexpected light emission from tyrosyl radicals as a probe for tyrosine oxidation

    Ignasiak, M., Frackowiak, K., Pedzinski, T., Davies, Michael Jonathan & Marciniak, B., 2020, In: Free Radical Biology and Medicine. 153, p. 12-16 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites

    Leinisch, F., Mariotti, M., Andersen, Sofie Hagel, Lindemose, S., Hägglund, Per Mårten, Møllegaard, Niels Erik & Davies, Michael Jonathan, 2020, In: Scientific Reports. 10, 1, 11 p., 3106.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

    Mizdrak, J., Hains, P. G., Truscott, R. J. W., Jamie, J. F. & Davies, Michael Jonathan, 15 Mar 2008, In: Free Radical Biology & Medicine. 44, 6, p. 1108-19 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

    Hawkins, Clare Louise, Pattison, D. I., Stanley, N. R. & Davies, Michael Jonathan, 15 Dec 2008, In: Biochemical Journal. 416, 3, p. 441-52 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

    Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, Michael Jonathan, Hawkins, Clare Louise & Ashby, M. T., 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 1-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Thiocyanate supplementation decreases atherosclerotic plaque in mice expressing human myeloperoxidase

    Morgan, P. E., Laura, R. P., Maki, R. A., Reynolds, W. F. & Davies, Michael Jonathan, 27 Mar 2015, In: Free Radical Research. 49, 6, p. 743-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study

    Skaff, O., Pattison, D. I. & Davies, Michael Jonathan, 5 Aug 2008, In: Biochemistry. 47, 31, p. 8237-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage

    Skjoldager, N., Blanner Bang, M., Rykaer, M., Björnberg, O., Davies, Michael Jonathan, Svensson, B., Harris, P. & Hägglund, Per Mårten, Apr 2017, In: Scientific Reports. 7, 10 p., 46282.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction

    Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P. K. & Davies, Michael Jonathan, 1 Jan 2014, In: Biochemical Journal. 457, 1, p. 89-97 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

    Lord, M. S., Chuang, Christine, Melrose, J., Davies, Michael Jonathan, Iozzo, R. V. & Whitelock, J. M., Apr 2014, In: Matrix Biology. 35, p. 112-22 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation

    Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Oct 2005, In: Free Radical Biology & Medicine. 39, 7, p. 900-12 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme

    Hawkins, Clare Louise & Davies, Michael Jonathan, Nov 2005, In: Chemical Research in Toxicology. 18, 11, p. 1669-77 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The retina: oxidative stress and diabetes

    van Reyk, D. M., Gillies, M. C. & Davies, Michael Jonathan, 2003, In: Redox Report (Online). 8, 4, p. 187-92 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage

    Morin, B., Davies, Michael Jonathan & Dean, R. T., 15 Mar 1998, In: Biochemical Journal. 330 ( Pt 3), p. 1059-67 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The prevalence of depressive symptoms in a white European and South Asian population with impaired glucose regulation and screen-detected Type 2 diabetes mellitus: A comparison of two screening tools

    Aujla, N., Skinner, Timothy, Khunti, K. & Davies, Michael Jonathan, 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 896-905 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The prevalence of depression in White-European and South-Asian people with impaired glucose regulation and screen-detected type 2 diabetes mellitus

    Aujla, N., Abrams, K. R., Davies, Michael Jonathan, Taub, N., Skinner, Timothy & Khunti, K., 9 Nov 2009, In: PLoS ONE. 4, 11, e7755.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function

    Escobar-Álvarez, E., Leinisch, F., Araya, G., Monasterio, O., Lorentzen, L. G., Silva, E., Davies, Michael Jonathan & López-Alarcón, C., Nov 2017, In: Free Radical Biology and Medicine. 112, p. 60-68 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. The oxidative environment and protein damage

    Davies, Michael Jonathan, 17 Jan 2005, In: B B A - Reviews on Cancer. 1703, 2, p. 93-109 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice

    Kim, C. H. J., Mitchell, J. B., Bursill, C. A., Sowers, A. L., Thetford, A., Cook, J. A., van Reyk, D. M. & Davies, Michael Jonathan, May 2015, In: Atherosclerosis. 240, 1, p. 234-241 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. The nitroxide TEMPO is an efficient scavenger of protein radicals: cellular and kinetic studies

    Pattison, D. I., Lam, M., Shinde, S. S., Anderson, R. F. & Davies, Michael Jonathan, 1 Nov 2012, In: Free Radical Biology & Medicine. 53, 9, p. 1664-74 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues

    Cook, N. L., Moeke, C. H., Fantoni, L. I., Pattison, D. I. & Davies, Michael Jonathan, 1 Jan 2016, In: Free Radical Biology & Medicine. 90, p. 195-205 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

    Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael Jonathan, 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

    Graham, G. G., Davies, Michael Jonathan, Day, R. O., Mohamudally, A. & Scott, K. F., Jun 2013, In: Inflammopharmacology. 21, 3, p. 201-32 32 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes

    Sevcnikar, B., Schaffner, I., Chuang, Christine, Gamon, L., Paumann-Page, M., Hofbauer, S., Davies, Michael Jonathan, Furtmüller, P. G. & Obinger, C., 15 Aug 2020, In: Archives of Biochemistry and Biophysics. 689, 7 p., 108443.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

    Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael Jonathan, Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing

    Park, J. I., Grant, C. M., Davies, Michael Jonathan & Dawes, I. W., 4 Sep 1998, In: The Journal of Biological Chemistry. 273, 36, p. 22921-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    The association between depression and health-related quality of life in people with type 2 diabetes: A systematic literature review

    Ali, S., Stone, M., Skinner, Timothy, Robertson, N., Davies, Michael Jonathan & Khunti, K., 1 Feb 2010, In: Diabetes/Metabolism Research and Reviews. 26, 2, p. 75-89 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    The association between anxiety and measures of glycaemia in a population-based diabetes screening programme

    Aujla, N., Davies, Michael Jonathan, Skinner, Timothy, Gray, L. J., Webb, D. R., Srinivasan, Balaji & Khunti, K., 1 Jul 2011, In: Diabetic Medicine. 28, 7, p. 785-788 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease

    Davies, Michael Jonathan & Hawkins, Clare Louise, 2020, In: Antioxidants & Redox Signaling. 32, 13, p. 957-981

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    The DESMOND educational intervention

    Davies, Michael Jonathan, Heller, S., Khunti, K. & Skinner, Timothy, 1 Mar 2008, In: Chronic Illness. 4, 1, p. 38-40 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  38. Published

    Tempus fugit horizontal ellipsis

    Davies, Michael Jonathan, 2019, In: Free Radical Research. 53, 1, p. 1-1

    Research output: Contribution to journal › Editorial › Research › peer-review

  39. Published

    Temperature Activated Diffusion of Radicals through Ion Implanted Polymers

    Wakelin, E. A., Davies, Michael Jonathan, Bilek, M. M. M. & McKenzie, D. R., 2 Dec 2015, In: A C S Applied Materials and Interfaces. 7, 47, p. 26340-26345 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

    Thallas-Bonke, V., Coughlan, M. T., Tan, A. L., Harcourt, B. E., Morgan, P. E., Davies, Michael Jonathan, Bach, L. A., Cooper, M. E. & Forbes, J. M., Jan 2013, In: Nephrology. 18, 1, p. 47-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

    Borges, E. L., Ignasiak, M. T., Velichenko, Y., Perin, G., Hutton, C. A., Davies, Michael Jonathan & Schiesser, C. H., 25 Mar 2018, In: Chemical Communications. 54, 24, p. 2990-2993

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Synthesis and antioxidant capacity of 5-selenopyranose derivatives

    Storkey, C., Davies, Michael Jonathan, White, J. M. & Schiesser, C. H., 14 Sep 2011, In: Chemical communications (Cambridge, England). 47, 34, p. 9693-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice

    Brown, B. E., Kim, C. H. J., Torpy, F. R., Bursill, C. A., McRobb, L. S., Heather, A. K., Davies, Michael Jonathan & van Reyk, D. M., Feb 2014, In: Atherosclerosis. 232, 2, p. 403-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Superoxide radicals react with peptide-derived tryptophan radicals with very high rate constants to give hydroperoxides as major products

    Carroll, L., Pattison, D. I., Davies, J. B., Anderson, R. F., Lopez-Alarcon, C. & Davies, Michael Jonathan, Apr 2018, In: Free Radical Biology and Medicine. 118, p. 126-136

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Superoxide radicals have a protective role during H2O2 stress

    Thorpe, G. W., Reodica, M., Davies, Michael Jonathan, Heeren, G., Jarolim, S., Pillay, B., Breitenbach, M., Higgins, V. J. & Dawes, I. W., Sep 2013, In: Molecular Biology of the Cell. 24, 18, p. 2876-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins

    Hawkins, Clare Louise, Rees, M. D. & Davies, Michael Jonathan, 2 Jan 2002, In: FEBS letters. 510, 1-2, p. 41-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Sulfur and selenium in oxidation protection

    Davies, Michael Jonathan, 2015, In: La chimica e l’industria, Chimica & Materiali. 2015, 6, p. 50-54

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals

    Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael Jonathan, Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Stable markers of oxidant damage to proteins and their application in the study of human disease

    Davies, Michael Jonathan, Fu, S., Wang, H. & Dean, R. T., Dec 1999, In: Free Radical Biology & Medicine. 27, 11-12, p. 1151-63 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Special issue for the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017)

    Khramtsov, V. V. & Davies, Michael Jonathan, 2018, In: Free Radical Research. 52, 3, p. 305-306

    Research output: Contribution to journal › Editorial › Research

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