Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:


    1. Published

      Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors

      van der Velden, W. J. C., Heitman, L. H. & Rosenkilde, Mette, 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 179-189 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

      van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action

      de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2

      Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson's Disease

      Zhang, L., Zhang, L., Li, Y., Li, L., Melchiorsen, J. U., Rosenkilde, Mette & Holscher, C., 2020, In: Journal of Parkinson's Disease. 10, 2, p. 523-542

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636)

      Zachariassen, Z. G., Karlshøj, S., Haug, B. E., Rosenkilde, Mette & Vabeno, J., 22 Oct 2015, In: Journal of Medicinal Chemistry. 58, 20, p. 8141-8153 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

      Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

      Yuliantie, E., van der Velden, W. J. C., Labroska, V., Dai, A., Zhao, F., Darbalaei, S., Deganutti, G., Xu, T., Zhou, Q., Yang, D., Rosenkilde, Mette, Sexton, P. M., Wang, M. W. & Wootten, D., 2021, In: Biochemical Pharmacology. 192, 16 p., 114715.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. E-pub ahead of print
    10. Published

      Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

      Willard, F. S., Douros, J. D., Gabe, M., Showalter, A. D., Wainscott, D. B., Suter, T. M., Capozzi, M. E., van der Velden, W. J. C., Stutsman, C., Cardona, G. R., Urva, S., Emmerson, P. J., Holst, Jens Juul, D'Alessio, D. A., Coghlan, M. P., Rosenkilde, Mette, Campbell, J. E. & Sloop, K. W., 2020, In: JCI insight. 5, 17, 16 p., 140532.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial

      Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Identification of a Salt Bridge That Is Functionally Important for Chemokine Receptor CXCR1 but not CXCR2

      Våbenø, J., Oliva-Santiago, M., Jørgensen, Astrid Sissel, Karlshøj, S. & Rosenkilde, Mette, 2023, In: ACS Pharmacology and Translational Science. 6, 8, p. 1120-1128 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      “Glyco-sulfo barcodes” regulate chemokine receptor function

      Verhallen, L., Lackman, Jarkko Juhani, Wendt, R., Gustavsson, Martin, Yang, Zhang, Narimatsu, Yoshiki, Sørensen, Daniel Madriz, Lafferty, K. M., Gouwy, M., Marques, P. E., Hjortø, Gertrud Malene, Rosenkilde, Mette, Proost, P. & Goth, C. K., 2023, In: Cellular and Molecular Life Sciences. 80, 2, 18 p., 55.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists

      Vabeno, J., Haug, B. E. & Rosenkilde, Mette, Jul 2015, In: Future Medicinal Chemistry. 7, 10, p. 1261-1283 23 p.

      Research output: Contribution to journalReviewResearchpeer-review

    17. Published

      Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

      Ugleholdt, Randi Kjærsgaard, Poulsen, M. H., Holst, Peter Johannes, Irminger, J., Orskov, C., Pedersen, Jens, Rosenkilde, Mette, Zhu, X., Steiner, D. F. & Holst, Jens Juul, 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

      Ugleholdt, Randi Kjærsgaard, Pedersen, Jens, Bassi, Maria Rosaria, Füchtbauer, E., Jørgensen, S. M., Kissow, Hannelouise, Nytofte, N., Poulsen, Steen Seier, Rosenkilde, Mette, Seino, Y., Thams, P., Holst, Peter Johannes & Holst, Jens Juul, Dec 2011, In: The Journal of Biological Chemistry. 286, 52, p. 44632-44645 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

      Tsutsumi, N., Qu, Q., Mavri, M., Baggesen, M. S., Maeda, S., Waghray, D., Berg, Christian, Kobilka, B. K., Rosenkilde, Mette, Skiniotis, G. & Garcia, K. C., 2021, In: Immunity. 54, 7, p. 1405-+ 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

      Toräng, S., Bojsen-Møller, K. N., Svane, M. S., Hartmann, Bolette, Rosenkilde, Mette, Madsbad, Sten & Holst, Jens Juul, 27 Jan 2016, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 310, 1, p. R866-R874 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo.

      Toräng, S., Veedfald, Simon, Rosenkilde, Mette, Hartmann, Bolette & Holst, Jens Juul, 20 Jul 2015, In: Physiological Reports. 3, 7, p. 1-8 8 p., e12455.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

      Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, GIANT Consortium, G. C., 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, E., Xue, K., Giller, K., Becker, S., Mujezinovic, A., Bentzen, Bo Hjorth, Andreas, L. B., Kolocouris, A., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Communications Biology. 4, 10 p., 1347.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Reply to: How Many SARS-CoV-2 "Viroporins" Are Really Ion Channels? [Inkl. Correction]

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Landbrug, A., Mujezinovic, A., Bentzen, Bo Hjorth, Kledal, T. N. & Rosenkilde, Mette, 2022, In: Communications Biology . 5, 1, 1 p., 860.

      Research output: Contribution to journalLetterResearchpeer-review

    25. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

      Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

      Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Interaction of chemokines with their receptors--from initial chemokine binding to receptor activating steps

      Thiele, S. & Rosenkilde, Mette, 2014, In: Current Medicinal Chemistry. 21, 31, p. 3594-614 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

      Sun, W., Chen, L-N., Zhou, Q., Zhao, L-H., Yang, D., Zhang, H., Cong, Z., Shen, D-D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W. J. C., Zhao, S., Jiang, Y., Rosenkilde, M. M., Xu, H. E., Zhang, Y. & 1 others, Wang, M., 2020, In: Cell Research. 30, 12, p. 1098-1108

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Effects of endogenous GIP in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published
    32. Published
    33. Published

      Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.

      Research output: Contribution to journalConference abstract in journalResearch

    34. Published

      Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.

      Research output: Contribution to journalConference abstract in journalResearch

    35. Published

      Molecular Pharmacology of CXCR4 inhibition

      Steen, A. & Rosenkilde, Mette, 2012, Novel Developments in Stem Cell Mobilization : Focus on CXCR4. Fruehauf, S., Zeller, J. W. & Calandra, G. (eds.). Springer Science+Business Media, p. 23-35

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    36. Published

      Biased and g protein-independent signaling of chemokine receptors

      Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Targeting CXCR4 in HIV Cell-Entry Inhibition

      Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7

      Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)

      Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

      Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells

      Spiess, Katja, Jeppesen, Mads Gravers, Malmgaard-Clausen, M., Krzywkowski, K., Kledal, T. N. & Rosenkilde, Mette, 2017, In: Journal of Immunology Research. 2017, 12 p., 4069260.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses

      Spiess, Katja, Fares, S., wbf943, wbf943, Hilgenberg, E., Jarvis, M. A., Ehlers, B. & Rosenkilde, Mette, Feb 2015, In: Journal of Virology. 89, 4, p. 2253-67 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors

      Spiess, Katja & Rosenkilde, Mette, 2014, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. Stevens, C. W. (ed.). Humana Press, p. 45-64 20 p. (Methods in Pharmacology and Toxicology).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    44. Published

      Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

      Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      The future of antiviral immunotoxins

      Spiess, Katja, Jakobsen, M. H., Kledal, T. N. & Rosenkilde, Mette, Jun 2016, In: Journal of Leukocyte Biology. 99, 6, p. 911-925 15 p.

      Research output: Contribution to journalReviewResearchpeer-review

    46. Published

      GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

      wbf943, wbf943, Gabe, M. N., Gasbjerg, Lærke Smidt, Christiansen, Charlotte Bayer, Svendsen, B., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2017, In: Biochemical Pharmacology. 131, p. 78-88

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors

      wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

      Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, David E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, Mette, Sotelo, E., Tiemann, Johanna Katarina Sofie, Tobin, A., Vardjan, N., Waldhoer, M. & Kolb, P., 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 361-370 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

      Smit, F. X., van der Velden, W. J. C., Kizilkaya, Hüsün Sheyma, Nørskov, A., Lückmann, Michael, Hansen, T. N., wbf943, wbf943, Qvotrup, K., Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Accepted/In press

      Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

      Skov-Jeppesen, Kirsa, Christiansen, Charlotte Bayer, Hansen, L. S., Windeløv, Johanne Agerlin, Hedbäck, N., Gasbjerg, Lærke Smidt, Hindsø, M., Svane, M. S., Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

      Research output: Contribution to journalJournal articleResearchpeer-review

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