Christina Christoffersen
Associate Professor
Physiology of circulation, kidney and lung
Blegdamsvej 3
2200 København N.
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Familial hypercholesterolaemia: cholesterol efflux and coronary disease
Versmissen, J., Vongpromek, R., Yahya, R., van der Net, J. B., van Vark-van der Zee, L., Blommesteijn-Touw, J., Wattimena, D., Rietveld, T., Pullinger, C. R., Christoffersen, Christina, Dahlbäck, B., Kane, J. P., Mulder, M. & Sijbrands, E. J. G., Jul 2016, In: European Journal of Clinical Investigation. 46, 7, p. 643-50 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
Al-Mashhadi, R. H., Sørensen, C. B., Kragh, P. M., Christoffersen, C., Mortensen, M. B., Tolbod, L. P., Thim, T., Du, Y., Li, J., Liu, Y., Moldt, B., Schmidt, M., Vajta, G., Larsen, T., Purup, S., Bolund, L., Nielsen, L. B., Callesen, H., Falk, E., Mikkelsen, J. G. & 1 others, , 2013, In: Science Translational Medicine. 5, 166, 11 p., 166ra1.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy
Enevoldsen, L. H., Tindborg, M., Hovmand, N. L., Christoffersen, Christina, Ellingsgaard, H., Suetta, Charlotte, Stallknecht, Bente Merete, Jennum, Poul, Kjær, Andreas & Gammeltoft, S., 2018, In: Sleep. 41, 8, p. 1-9 zsy092.Research output: Contribution to journal › Journal article › Research › peer-review
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Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding
Tian, E., Wang, S., Zhang, L., Zhang, Y., Malicdan, M. C., Mao, Y., Christoffersen, Christina, Tabak, L. A., Schjoldager, Katrine Ter-Borch Gram & Ten Hagen, K. G., 10 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 50, p. 25196-25202Research output: Contribution to journal › Journal article › Research › peer-review
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Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort
Stadler, J. T., van Poppel, M. N. M., Christoffersen, Christina, Hill, D., Wadsack, C., Simmons, D., Desoye, G., Marsche, G. & DALI Core Investigator Grp, 2023, In: Antioxidants. 12, 1, 13 p., 68.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
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HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver
Ding, B., Liu, C. H., Sun, Y., Chen, Y., Swendeman, S. L., Jung, B., Chavez, D., Cao, Z., Christoffersen, Christina, Nielsen, L. B., Schwab, S. R., Rafii, S. & Hla, T., 22 Dec 2016, In: JCI insight. 1, 21, 16 p., e87058.Research output: Contribution to journal › Journal article › Research › peer-review
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Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
Christoffersen, Christina, Bartels, Emil Daniel & Nielsen, L. B., Feb 2006, In: European Journal of Clinical Investigation. 36, 2, p. 69-75 7 p.Research output: Contribution to journal › Journal article › Research
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Heparininduceret trombocytopeni
Christoffersen, Christina, Lethagen, S. & Goetze, Jens P. , 16 Feb 2009, In: Ugeskrift for Laeger. 171, 8, p. 612-5 4 p.Research output: Contribution to journal › Journal article › Research
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression
Feuerborn, R., Becker, S., Potì, F., Nagel, P., Brodde, M., Schmidt, H., Christoffersen, Christina, Ceglarek, U., Burkhardt, R. & Nofer, J., Feb 2017, In: Atherosclerosis. 257, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of Atherosclerosis
Pedersen, A. A., Pedersen, T. X., Junker, N., Christoffersen, Christina, Bartels, Emil Daniel, Madsen, M., Nielsen, Carsten Haagen & Nielsen, L. B., Sep 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 9, p. 1782-1790 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of Glomerular and Plasma Apolipoprotein M as Novel Biomarkers in Glomerular Disease
Drexler, Y., Molina, J., Elfassy, T., Ma, R., Christoffersen, Christina, Kurano, M., Yatomi, Y., Mariani, L. H., Contreras, G., Merscher, S. & Fornoni, A., 2023, In: Kidney International Reports. 8, 4, p. 884-897Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice
Gordts, P. L. S. M., Bartelt, A., Nilsson, S. K., Annaert, W., Christoffersen, Christina, Nielsen, L. B., Heeren, J. & Roebroek, A. J. M., 2012, In: P L o S One. 7, 6, p. e38330Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, Klaus, Nielsen, L. B., Hla, T., Di Lorenzo, A. & Christoffersen, Christina, Jun 2016, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30, 6, p. 2351-2359 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased cardiac BNP expression associated with myocardial ischemia
Goetze, Jens P. , Christoffersen, Christina, Perko, M., Arendrup, H., Rehfeld, Jens Frederik, Kastrup, J. & Nielsen, L. B., Jun 2003, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 9, p. 1105-7 3 p.Research output: Contribution to journal › Journal article › Research
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Increased plasma apoM levels impair triglyceride turnover in mice
Hajny, Stefan, Borup, A., Elsoe, S. & Christoffersen, Christina, 2021, In: B B A - Molecular and Cell Biology of Lipids. 1866, 9, 9 p., 158969.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of atherosclerosis in mice and hamsters without germline genetic engineering
Bjørklund, M. M., Hollensen, A. K., Hagensen, M. K., Dagnæs-Hansen, F., Christoffersen, Christina, Mikkelsen, J. G. & Bentzon, J. F., 23 May 2014, In: Circulation Research. 114, 11, p. 1684-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation and characterization of human apolipoprotein M-containing lipoproteins
Christoffersen, Christina, Nielsen, L. B., Axler, O., Andersson, A., Johnsen, A. H. & Dahlbäck, B., Aug 2006, In: Journal of Lipid Research. 47, 8, p. 1833-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KIDNEY DERIVED APOM AND ITS ROLE IN ACUTE KIDNEY INJURY
Bisgaard, Line, Christensen, P. M., Fuchtbauer, E., Nielsen, L. B. & Christoffersen, Christina, 2021, In: Nephrology Dialysis Transplantation. 36, Suppl. 1, p. 240-240 MO339.Research output: Contribution to journal › Conference abstract in journal › Research
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Kidney derived apolipoprotein M and its role in acute kidney injury
Bisgaard, Line, Christensen, P. M., Oh, J., Torta, F., Füchtbauer, E. M., Nielsen, L. B. & Christoffersen, Christina, 2024, In: Frontiers in Pharmacology. 15, 1328259.Research output: Contribution to journal › Journal article › Research › peer-review
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Left ventricular structure and function in patients with chronic kidney disease assessed by 3D echocardiography: the CPH-CKD ECHO study
Christensen, J., Landler, N. E., Olsen, F. J., Feldt-Rasmussen, Bo, Hansen, Ditte, Kamper, A. L., Christoffersen, Christina, Ballegaard, E. L. F., Sørensen, I. M. H., Bjergfelt, S. S., Seidelin, E., Bro, S. & Biering-Sørensen, Tor, 2022, In: International Journal of Cardiovascular Imaging. 38, 6, p. 1233–1244 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway
Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents
Khetarpal, S. A., Schjoldager, K. T., Christoffersen, C., Raghavan, A., Edmondson, A. C., Reutter, H. M., Ahmed, B., Ouazzani, R., Peloso, G. M., Vitali, C., Zhao, W., Somasundara, A. V. H., Millar, J. S., Park, Y., Fernando, G., Livanov, V., Choi, S., Noé, E., Patel, P., Ho, S. P. & 12 others, , 9 Aug 2016, In: Cell Metabolism. 24, 2, p. 234-245 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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METABOLIC PROFILING AS A MARKER OF CARDIOVASCULAR DISEASE AND ARTERIAL CALCIFICATION IN THE COPENHAGEN CHRONIC KIDNEY DISEASE COHORT
Soerensen, I. M. H., Bisgaard, Line, Bjergfelt, S. S., Ballegaard, E. L. F., Biering-Sørensen, Tor, Landler, N. E., Kofoed, Klaus Fuglsang, Lange, Theis, Feldt-Rasmussen, Bo, Bro, S. & Christoffersen, Christina, 2021, In: Nephrology Dialysis Transplantation. 36, Suppl. 1, 2 p., FC060.Research output: Contribution to journal › Conference abstract in journal › Research
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Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways
Kristiansen, M., Veidal, S. S., Christoffersen, Christina, Jelsing, J. & Rigbolt, K. T. G., 2019, In: Lipids. 54, 1, p. 109-115Research output: Contribution to journal › Journal article › Research › peer-review
ID: 18392597
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A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation
Research output: Contribution to journal › Review › Research › peer-review
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252
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Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes
Research output: Contribution to journal › Journal article › Research › peer-review
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240
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The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity
Research output: Contribution to journal › Journal article › Research › peer-review
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