Increased plasma apoM levels impair triglyceride turnover in mice

Research output: Contribution to journalJournal articleResearchpeer-review


Objective: Apolipopmtein M (apoM) is an essential transporter of plasma Sphingosine-1 -Phosphate (S1P), typically attached to all lipoprotein classes, but with a majority bound to high density lipoproteins (HDL). ApoM-deficient mice display an increased activity in brown adipose tissue and a concomitant fast turnover of triglycerides. In what manner apoM/S1P affect the triglyceride metabolism is however still unknown and explored in the present study.

Methods: Triglyceride turnover and potentially associated metabolic pathways were studied in the female human apoM transgenic mouse model (apoM-Tg) with increased plasma apoM and SIP levels. The model was compared with wild type (WT) mice.

Results: ApoM-Tg mice had a reduced plasma triglyceride turnover rate and a lower free fatty acid uptake in subcutaneous adipocytes compared to WT mice. Screening for potential molecular mechanisms furthermore revealed a reduction in plasma lipase activity in apoM-Tg animals. Overexpression of apoM also reduced the plasma levels of fibroblast growth factor 21 (FGF21).

Conclusions: The study features the significant role of the apoM/S1P axis in maintaining a balanced triglyceride metabolism. Further, it also highlights the risk of inducing dyslipidaemia in patients receiving S1P-analouges and additionlly emphasizes the apoM/S1P axis as a potential therapeutic target in treatment of hypertriglyceridemia.

Original languageEnglish
Article number158969
JournalB B A - Molecular and Cell Biology of Lipids
Issue number9
Number of pages9
Publication statusPublished - 2021

    Research areas

  • Adipose tissue, Sphingosine-1-phosphate, Apolipoprotein(s), Plasma triglyceride metabolism, Lipase(s), Fibroblast growth factor 21, APOLIPOPROTEIN-M, SPHINGOSINE 1-PHOSPHATE, HEPATIC LIPASE, LIPOPROTEIN-LIPASE, RICH LIPOPROTEINS, BETA-KLOTHO, GROWTH, SPHINGOSINE-1-PHOSPHATE, CHOLESTEROL, METABOLISM

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 274271793