Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice

Research output: Contribution to journalJournal articleResearch

Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
Original languageEnglish
JournalEuropean Journal of Clinical Investigation
Issue number2
Pages (from-to)69-75
Number of pages7
Publication statusPublished - Feb 2006

    Research areas

  • Animals, Atrial Natriuretic Factor, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Guanylate Cyclase, Heart, Male, Mice, Mice, Inbred C57BL, Natriuretic Peptide, Brain, Natriuretic Peptide, C-Type, Natriuretic Peptides, RNA, Messenger, Receptors, Atrial Natriuretic Factor, Up-Regulation

ID: 100888776