Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
Research output: Contribution to journal › Journal article
Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Investigation |
| Volume | 36 |
| Issue number | 2 |
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| ISSN | 0014-2972 |
| DOIs | |
| Publication status | Published - Feb 2006 |
- Animals, Atrial Natriuretic Factor, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Guanylate Cyclase, Heart, Male, Mice, Mice, Inbred C57BL, Natriuretic Peptide, Brain, Natriuretic Peptide, C-Type, Natriuretic Peptides, RNA, Messenger, Receptors, Atrial Natriuretic Factor, Up-Regulation
Research areas
ID: 100888776