Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort

Research output: Contribution to journalJournal articleResearchpeer-review


  • Julia T. Stadler
  • M. N. M. van Poppel
  • Christoffersen, Christina
  • David Hill
  • Christian Wadsack
  • David Simmons
  • Gernot Desoye
  • Gunther Marsche
  • DALI Core Investigator Grp

Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at

Original languageEnglish
Article number68
Issue number1
Number of pages13
Publication statusPublished - 2023

    Research areas

  • gestational hypertension, HDL, cholesterol efflux capacity, paraoxonase-1, apolipoprotein M, pregnancy, obesity, APOLIPOPROTEIN-M, CARDIOVASCULAR-DISEASE, CHOLESTEROL EFFLUX, PREECLAMPSIA, PREGNANCY, PROTEIN, RISK, POLYMORPHISMS, CAPACITY

ID: 335690724