Christina Christoffersen
Associate Professor
Physiology of circulation, kidney and lung
Blegdamsvej 3
2200 København N.
- Published
Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs
Al-Mashhadi, R. H., Bjørklund, M. M., Mortensen, M. B., Christoffersen, Christina, Larsen, T., Falk, E. & Bentzon, J. F., 2015, In: Diabetologia. 58, 8, p. 1926-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
Al-Mashhadi, R. H., Sørensen, C. B., Kragh, P. M., Christoffersen, C., Mortensen, M. B., Tolbod, L. P., Thim, T., Du, Y., Li, J., Liu, Y., Moldt, B., Schmidt, M., Vajta, G., Larsen, T., Purup, S., Bolund, L., Nielsen, L. B., Callesen, H., Falk, E., Mikkelsen, J. G. & 1 others, , 2013, In: Science Translational Medicine. 5, 166, 11 p., 166ra1.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosis
Arkensteijn, B. W. C., Berbée, J. F. P., Rensen, P. C. N., Nielsen, L. B. & Christoffersen, Christina, 25 Feb 2013, In: International Journal of Molecular Sciences (Online). 14, 3, p. 4419-31 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression
Bartels, Emil Daniel, Christoffersen, Christina, Lindholm, M. W. & Nielsen, L. B., 2015, In: Circulation Research. 117, p. 933-942 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of atrial natriuretic peptide on lipolysis in the mouse heart
Bartels, Emil Daniel, Bisgaard, Line, Christoffersen, Christina & Nielsen, L. B., 2014, In: Cardiovascular Endocrinology. 3, 3, p. 92-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology
Bisgaard, L. S. & Christoffersen, Christina, 2019, In: Current Opinion in Lipidology. 30, 3, p. 212-217Research output: Contribution to journal › Review › Research › peer-review
- Published
Kidney derived apolipoprotein M and its role in acute kidney injury
Bisgaard, Line, Christensen, P. M., Oh, J., Torta, F., Füchtbauer, E. M., Nielsen, L. B. & Christoffersen, Christina, 2024, In: Frontiers in Pharmacology. 15, 1328259.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The apoM/S1P Complex - A Mediator in Kidney Biology and Disease?
Bisgaard, Line & Christoffersen, Christina, 2021, In: Frontiers in Medicine. 8, 11 p., 754490.Research output: Contribution to journal › Review › Research › peer-review
- Published
KIDNEY DERIVED APOM AND ITS ROLE IN ACUTE KIDNEY INJURY
Bisgaard, Line, Christensen, P. M., Fuchtbauer, E., Nielsen, L. B. & Christoffersen, Christina, 2021, In: Nephrology Dialysis Transplantation. 36, Suppl. 1, p. 240-240 MO339.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification
Bjergfelt, S. S., Sørensen, I. M. H., Hjortkjær, H., Landler, N., Ballegaard, E. L. F., Biering-Sørensen, Tor, Kofoed, Klaus Fuglsang, Lange, Theis, Feldt-Rasmussen, Bo, Sillesen, Henrik, Christoffersen, Christina & Bro, S., 2021, In: PLoS ONE. 16, 16 p., e0260417.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of atherosclerosis in mice and hamsters without germline genetic engineering
Bjørklund, M. M., Hollensen, A. K., Hagensen, M. K., Dagnæs-Hansen, F., Christoffersen, Christina, Mikkelsen, J. G. & Bentzon, J. F., 23 May 2014, In: Circulation Research. 114, 11, p. 1684-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans
Borup, A., Donkin, I., Boon, M. R., Frydland, M., Martinez-Tellez, B., Loft, A., Keller, S. H., Kjær, Andreas, Kjærgaard, Jesper, Hassager, Christian, Barrès, Romain, Rensen, P. C. N. & Christoffersen, Christina, 2022, In: Scientific Reports. 12, 1, 11 p., 18753.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M in lipid metabolism and cardiometabolic diseases
Borup, A., Christensen, P. M., Nielsen, L. B. & Christoffersen, Christina, Feb 2015, In: Current Opinion in Lipidology. 26, 1, p. 48-55 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protein unfolding allows use of commercial antibodies in an apolipoprotein M sandwich ELISA
Bosteen, M. H., Dahlbäck, B., Nielsen, L. B. & Christoffersen, Christina, 1 Mar 2015, In: Journal of Lipid Research. 56, 3, p. 754-759 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of apolipoprotein M in uremic atherosclerosis
Bosteen, M. H., Madsen Svarrer, E. M., Bisgaard, Line, Martinussen, Torben, Madsen, M., Nielsen, L. B., Christoffersen, Christina & Pedersen, T. X., Oct 2017, In: Atherosclerosis. 265, p. 93-101 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diurnal regulation of sphingolipids in blood
Brunkhorst, R., Pfeilschifter, W., Rajkovic, N., Pfeffer, M., Fischer, C., Korf, H. W., Christoffersen, Christina, Trautmann, S., Thomas, D., Pfeilschifter, J. & Koch, A., 2019, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 3, p. 304-311Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Chirinos, J. A., Zhao, L., Jia, Y., Frej, C., Adamo, L., Mann, D., Shewale, S. V., Millar, J. S., Rader, D. J., French, B., Brandimarto, J., Margulies, K. B., Parks, J. S., Wang, Z., Sieffert, D. A., Fang, J., Sweitzer, N., Christoffersen, C., Dahlbäck, B., Car, B. D. & 3 others, , 2020, In: Circulation. 141, 18, p. 1463–1476Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Left ventricular structure and function in patients with chronic kidney disease assessed by 3D echocardiography: the CPH-CKD ECHO study
Christensen, J., Landler, N. E., Olsen, F. J., Feldt-Rasmussen, Bo, Hansen, Ditte, Kamper, A. L., Christoffersen, Christina, Ballegaard, E. L. F., Sørensen, I. M. H., Bjergfelt, S. S., Seidelin, E., Bro, S. & Biering-Sørensen, Tor, 2022, In: International Journal of Cardiovascular Imaging. 38, 6, p. 1233–1244 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, Klaus, Nielsen, L. B., Hla, T., Di Lorenzo, A. & Christoffersen, Christina, Jun 2016, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30, 6, p. 2351-2359 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes
Christensen, P. M., Bosteen, M. H., Hajny, Stefan, Nielsen, L. B. & Christoffersen, Christina, 8 Nov 2017, In: Scientific Reports. 7, 10 p., 14983.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ApoB and apoM - New aspects of lipoprotein biology in uremia-induced atherosclerosis
Christoffersen, Christina, Bartels, Emil Daniel, Pedersen, A. A., Nielsen, L. B. & Pedersen, T. X., Dec 2017, In: European Journal of Pharmacology. 816, p. 154-160 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The signal peptide anchors apolipoprotein m in plasma lipoproteins and prevents rapid clearance of apolipoprotein m from plasma
Christoffersen, Christina, Ahnstrom, J., Axler, O., Christensen, E. I., Dahlback, B. & Nielsen, L. B., 2008, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 6, p. E62-E63Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diabetes and the endocrine heart
Christoffersen, Christina, Hunter, I., Jensen, Asger Lundorff & Goetze, Jens P. , Oct 2007, In: European Heart Journal. 28, 20, p. 2427-9 3 p.Research output: Contribution to journal › Editorial › Research
- Published
Apolipoprotein M - a new biomarker in sepsis
Christoffersen, Christina & Nielsen, L. B., 2012, In: Critical Care (Online Edition). 16, 3, p. 126Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M-A Marker or an Active Player in Type II Diabetes?
Christoffersen, Christina, 2021, In: Frontiers in Endocrinology. 12, 10 p., 665393.Research output: Contribution to journal › Review › Research › peer-review
- Published
Isolation and characterization of human apolipoprotein M-containing lipoproteins
Christoffersen, Christina, Nielsen, L. B., Axler, O., Andersson, A., Johnsen, A. H. & Dahlbäck, B., Aug 2006, In: Journal of Lipid Research. 47, 8, p. 1833-43 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles
Christoffersen, Christina, Benn, Marianne, Christensen, P. M., Gordts, P. L. S. M., Roebroek, A. J. M., Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Dahlback, B. & Nielsen, L. B., 2012, In: Journal of Lipid Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma
Christoffersen, Christina, Ahnström, J., Axler, O., Christensen, E. I., Dahlbäck, B. & Nielsen, L. B., 2008, In: Journal of Biological Chemistry. 283, 27, p. 18765-72 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M: progress in understanding its regulation and metabolic functions
Christoffersen, Christina, Dahlbäck, B. & Nielsen, L. B., 2006, In: Scandinavian Journal of Clinical & Laboratory Investigation. 66, 7, p. 631-7 7 p.Research output: Contribution to journal › Journal article › Research
- Published
Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
Christoffersen, Christina, Jauhiainen, M., Moser, M., Porse, Bo Torben, Ehnholm, C., Boesl, M., Dahlbäck, B. & Nielsen, L. B., 25 Jan 2008, In: The Journal of Biological Chemistry. 283, 4, p. 1839-47 9 p.Research output: Contribution to journal › Journal article › Research
- Published
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
Christoffersen, Christina, Obinata, H., Kumaraswamy, S. B., Galvani, S., Ahnström, J., Sevvana, M., Egerer-Sieber, C., Muller, Y. A., Hla, T., Nielsen, L. B. & Dahlbäck, B., 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 23, p. 9613-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis
Christoffersen, Christina, Pedersen, T. X., Gordts, P. L. S. M., Roebroek, A. J. M., Dahlbäck, B. & Nielsen, L. B., 2010, In: Circulation Research. 106, 10, p. 1624-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M: bridging HDL and endothelial function
Christoffersen, Christina & Nielsen, L. B., Aug 2013, In: Current Opinion in Lipidology. 24, 4, p. 295-300 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity
Christoffersen, Christina, Federspiel, C. K., Borup, A., Christensen, P. M., Madsen, A. N., Heine, M., Nielsen, C. H., Kjaer, A., Holst, Birgitte, Heeren, J. & Nielsen, L. B., 2 Jan 2018, In: Cell Reports. 22, 1, p. 175-188Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
Christoffersen, Christina, Bartels, Emil Daniel & Nielsen, L. B., Feb 2006, In: European Journal of Clinical Investigation. 36, 2, p. 69-75 7 p.Research output: Contribution to journal › Journal article › Research
- Published
Chamber-dependent expression of brain natriuretic peptide and its mRNA in normal and diabetic pig heart
Christoffersen, Christina, Goetze, Jens P. , Bartels, Emil Daniel, Larsen, T. M., Ribel, U., Rehfeld, Jens Frederik, Rolin, B. & Nielsen, L. B., Jul 2002, In: Hypertension. 40, 1, p. 54-60 7 p.Research output: Contribution to journal › Journal article › Research
- Published
Cardiac lipid accumulation associated with diastolic dysfunction in obese mice
Christoffersen, Christina, Bollano, E., Lindegaard, M. L. S., Bartels, Emil Daniel, Goetze, Jens P. , Andersen, C. B. & Nielsen, L. B., Aug 2003, In: Molecular Endocrinology. 144, 8, p. 3483-90 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heparininduceret trombocytopeni
Christoffersen, Christina, Lethagen, S. & Goetze, Jens P. , 16 Feb 2009, In: Ugeskrift for Laeger. 171, 8, p. 612-5 4 p.Research output: Contribution to journal › Journal article › Research
- Published
Apolipoprotein M: Impact on lipoprotein metabolism and vascular function
Christoffersen, Christina, 2014, Frederiksberg: Det Sundhedsvidenskabelige Fakultet, Københavns Universitet. 118 p.Research output: Book/Report › Doctoral thesis › Research
- Published
Apolipoprotein M: Structure and Function
Dahlback, B., Ahnstrom, J., Christoffersen, Christina & Nielsen, L. B., 2008, In: Future Lipidology. 3, p. 495-503Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature
Del Gaudio, I., Sreckovic, I., Zardoya-Laguardia, P., Bernhart, E., Christoffersen, Christina, Frank, S., Marsche, G., Illanes, S. E. & Wadsack, C., 2020, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1865, 4, 11 p., 158632.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair
Ding, B. S., Yang, D., Swendeman, S. L., Christoffersen, Christina, Nielsen, L. B., Friedman, S. L., Powell, C. A., Hla, T. & Cao, Z., 2020, In: Developmental Cell. 53, 6, p. 677-690Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver
Ding, B., Liu, C. H., Sun, Y., Chen, Y., Swendeman, S. L., Jung, B., Chavez, D., Cao, Z., Christoffersen, Christina, Nielsen, L. B., Schwab, S. R., Rafii, S. & Hla, T., 22 Dec 2016, In: JCI insight. 1, 21, 16 p., e87058.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of Glomerular and Plasma Apolipoprotein M as Novel Biomarkers in Glomerular Disease
Drexler, Y., Molina, J., Elfassy, T., Ma, R., Christoffersen, Christina, Kurano, M., Yatomi, Y., Mariani, L. H., Contreras, G., Merscher, S. & Fornoni, A., 2023, In: Kidney International Reports. 8, 4, p. 884-897Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL
Elsøe, S., Ahnström, J., Christoffersen, Christina, Hoofnagle, A. N., Plomgaard, Peter Stendahl, Heinecke, J. W., Binder, C. J., Björkbacka, H., Dahlbäck, B. & Nielsen, L. B., 2012, In: Atherosclerosis. 221, 1, p. 91-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M promotes mobilization of cellular cholesterol in vivo
Elsøe, S., Christoffersen, Christina, Luchoomun, J., Turner, S. & Nielsen, L. B., Jul 2013, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1831, 7, p. 1287-92 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy
Enevoldsen, L. H., Tindborg, M., Hovmand, N. L., Christoffersen, Christina, Ellingsgaard, H., Suetta, Charlotte, Stallknecht, Bente Merete, Jennum, Poul, Kjær, Andreas & Gammeltoft, S., 2018, In: Sleep. 41, 8, p. 1-9 zsy092.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression
Feuerborn, R., Becker, S., Potì, F., Nagel, P., Brodde, M., Schmidt, H., Christoffersen, Christina, Ceglarek, U., Burkhardt, R. & Nofer, J., Feb 2017, In: Atherosclerosis. 257, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Galsgaard, Katrine Douglas, Elmelund, E., Johansen, C. D., Billeschou, Anna, Kizilkaya, Hüsün Sheyma, Ceutz, F., Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Winther-Sørensen, Marie, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Rosenkilde, Mette, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Molecular Metabolism. 66, 14 p., 101639.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neonatal HDL Counteracts Placental Vascular Inflammation via S1P-S1PR1 Axis
Gaudio, I. D., Hendrix, S., Christoffersen, Christina & Wadsack, C., 25 Jan 2020, In: International Journal of Molecular Sciences. 21, 3, 789.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 18392597
Most downloads
-
265
downloads
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation
Research output: Contribution to journal › Review › Research › peer-review
Published -
252
downloads
Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
240
downloads
The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity
Research output: Contribution to journal › Journal article › Research › peer-review
Published