Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

Research output: Contribution to journalJournal articlepeer-review

Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.
Original languageEnglish
JournalAtherosclerosis
Volume221
Issue number1
Pages (from-to)91-7
Number of pages7
ISSN0021-9150
DOIs
Publication statusPublished - 2012

    Research areas

  • Amidines, Animals, Antioxidants, Apolipoproteins, Atherosclerosis, Binding Sites, Cholesterol, Dietary, Disease Models, Animal, Humans, Lipocalins, Lipoproteins, HDL, Lipoproteins, LDL, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myristic Acid, Oxidants, Oxidation-Reduction, Phospholipids, Receptors, LDL, Recombinant Proteins, Thiobarbituric Acid Reactive Substances, Time Factors

ID: 38431824