Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
pjx571, pjx571, Mahendran, Y., Jonsson, Anna Elisabet, Gjesing, A. P., Weeke, P. E., Jørgensen, M. E., Færch, K., Witte, D. R., Holst, Jens Juul, Jørgensen, T., Grarup, N., Pedersen, Oluf Borbye, drb459, drb459, Torekov, Signe Sørensen, Kanters, Jørgen K. & Hansen, Torben, 2018, In: B M C Genetics. 19, 1, p. 1-9 9 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB
pjx571, pjx571, Lundgren, Jens, Albrechtsen, Nicolai Jacob Wewer, Mahendran, Y., Iepsen, E. P. W., Finocchietto, P., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, 2017, In: Obesity Science & Practice. 3, 4, p. 425-433 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels
pjx571, pjx571, Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, Dec 2016, In: Metabolomics. 12, 12, p. 1-9 9 p., 181.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release
Enc, F. Y., Imeryuz, N., Akin, L. & Holst, Jens Juul, 2001, In: Am J Physiol-Gastr L. 281, p. G752-G763Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal nutrient absorption in newborn pigs in response to enteral nutrition or treatment with glucagon-like peptide 2
Elnif, J., Buddington, R. K., Petersen, Y. M., Hartmann, B., Holst, Jens Juul, Schmidt, M., Burrin, D. G. & Sangild, Per Torp, 2001, Ikke angivet. Lindberg, J. E., Ogle & B. (eds.). CABI Publishing, p. 37-39 3 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Elmelund, E., Galsgaard, Katrine Douglas, Johansen, C. D., Trammell, Sam, Billeschou, Anna, Winther-Sørensen, Marie, Dal, Jenna Elizabeth Hunt, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Grevengoed, Trisha Jean, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: iScience. 25, 11, 20 p., 105296.Research output: Contribution to journal › Journal article › Research › peer-review
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Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
Ellrichmann, M., Kapelle, M., Ritter, P. R., Holst, Jens Juul, Herzig, K., Schmidt, W. E., Schmitz, F. & Meier, J. J., Oct 2008, In: The Journal of clinical endocrinology and metabolism. 93, 10, p. 3995-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
Ellrichmann, M., Kapelle, M., Ritter, P. R., Holst, Jens Juul, Herzig, K. H., Schmidt, W. E., Schmitz, F. & Meier, J. J., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 3995-3998 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
El-Ouaghlidi, A., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., Nov 2007, In: The Journal of clinical endocrinology and metabolism. 92, 11, p. 4165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection
Ekholm, E., Shaat, N. & Holst, Jens Juul, Oct 2012, In: Acta Diabetologica. 49, 5, p. 349-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy
Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenocortical steroidogenesis
Ehrhart-Bornstein, M., Bornstein, S. R., Gonzalez-Hernandez, J., Holst, Jens Juul, Watermann, M. R. & Scherbaum, W. A., 1995, In: Endocrine Research. 21, p. 13-24Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenal androstenedione release
Ehrhart-Bornstein, M., Bornstein, S. R., Behling, H. G., Holst, Jens Juul, Strohmayer, H. G., Rasmussen, T. N., Scherbaum, W. A. & Adler, G., 1994, In: Neuroendocrinology. 59, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
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Vasoactive intestinal peptide in the porcine adrenal gland
Ehrhart-Bornstein, M., Bornstein, S. R. & Holst, Jens Juul, 1991, In: Neuroendocrinology. 54, p. 623-628Research output: Contribution to journal › Journal article › Research › peer-review
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A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin
Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
Egerod, Kristoffer Lihme, Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Zhao, M., Barir-Jensen, D., Nygaard, E. B., Petersen, N., Holst, Jens Juul & Schwartz, Thue W., Nov 2015, In: Endocrinology. 156, 11, p. 3909-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of wheat bread influences the postprandial metabolic response in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
Edholm, T., Degerblad, M., Grybäck, P., Hilsted, Linda, Holst, Jens Juul, Jacobsson, H., Efendic, S., Schmidt, P. T. & Hellström, P. M., 1 Nov 2010, In: Neurogastroenterology and Motility Online. 22, 11, p. 1191-200, e315 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
Ebdrup, Bjørn, Knop, Filip Krag, Madsen, A., Mortensen, H. B., Søgaard, B., Holst, Jens Juul, Szecsi, P. B. & Lublin, H., Sep 2014, In: Journal of Clinical Psychiatry. 75, 9, p. e899-905 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation
Sørum, Maria Ebbesen, Kissow, Hannelouise, Hartmann, Bolette, Kielsen, K., Sørensen, K., Stinson, Sara, Frithioff-Bojsoe, C., Fonvig, Cilius Esmann, Holm, Jens-Christian, Hansen, Torben, Holst, Jens Juul & Müller, K. G., 2021, In: Frontiers in Immunology. 12, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 is a marker of systemic inflammation in patients treated with high-dose chemotherapy and autologous stem cell transplantation
Ebbesen, M. S., Kissow, Hannelouise, Hartmann, Bolette, Grell, Kathrine, Gørløv, J. S., Kielsen, K., Holst, Jens Juul & Muller, Klaus, 2019, In: Biology of Blood and Marrow Transplantation. 25, 6, p. 1085-1091 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa
Dynesen, A. W., Jensen, A. B., Astrup, A., Petersson, B., Holst, Jens Juul & Nauntofte, B., 2008, In: American Journal of Clinical Nutrition. 87, 1, p. 12-22 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Atrial natriuretic peptide-like immunoreactive material (ANP-L1) is released from the adrenal gland by splanchnic nerve stimulation
Duntas, L., Bornstein, S. R., Scherbaum, W. & Holst, Jens Juul, 1994, In: Exp.Clin.Endocrinol.. 101, p. 371-373Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monosaturated-fat, low-fat, and control diets
Due, A. P., Larsen, T. M., Hermansen, K., Stender, Steen, Holst, Jens Juul, Toubro, S., Martinussen, Torben & Astrup, A., 2008, In: American Journal of Clinical Nutrition. 87, 4, p. 855-862 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
Due, A. P., Larsen, T. M., Hermansen, K., Stender, Steen, Holst, Jens Juul, Toubro, S., Martinussen, Torben & Astrup, A., 2008, In: American Journal of Clinical Nutrition. 87, 4, p. 855-862 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The expanding incretin universe: from basic biology to clinical translation
Drucker, D. J. & Holst, Jens Juul, 2023, In: Diabetologia. 66, p. 1765-1779Research output: Contribution to journal › Review › Research › peer-review
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Discovery, characterization, and clinical development of the glucagon-like peptides
Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity
Dollerup, O. L., Trammell, Sam, Hartmann, Bolette, Holst, Jens Juul, Christensen, B., Møller, N., Gillum, M. P., Treebak, Jonas Thue & Jessen, N., 1 Nov 2019, In: The Journal of clinical endocrinology and metabolism. 104, 11, p. 5703-5714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Feast or famine - are GLP-1 and ghrelin secretion intertwined?
Djurhuus, C. B., Hansen, T. K., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 353-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion
Djurhuus, C. B., Hansen, T. K., Gravholt, C., Ørskov, L., Hosoda, H., Kangawa, K., Jørgensen, J. O. L., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 411-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity
Dirksen, C., Graff, J., Fuglsang, S., Rehfeld, Jens Frederik, Holst, Jens Juul & Madsen, J. L., 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 3, p. G332-G337Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report
Dirksen, C., Hansen, D. L., Madsbad, Sten, Hvolris, L. E., Naver, L. S., Holst, Jens Juul & Worm, Dorte, 2010, In: Diabetes Care. 33, 2, p. 375-377Research output: Contribution to journal › Journal article › Research › peer-review
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Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass
Dirksen, C., Bojsen-Møller, K. N., Jørgensen, N. B., Jacobsen, S. H., Kristiansen, V. B., Naver, L. S., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2013, In: Diabetologia. 56, 12, p. 2679-2687Research output: Contribution to journal › Journal article › Research › peer-review
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Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report
Dirksen, C., Jacobsen, S. H., Bojsen-Møller, K. N., Jørgensen, N. B., Naver, L. S., Hvolris, L. E., Worm, Dorte, Madsbad, Sten, Holst, Jens Juul & Hansen, D. L., 7 Dec 2013, In: Obesity Research & Clinical Practice. 7, 4, p. e269-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery
Dirksen, C., Eiken, A., Bojsen-Møller, K. N., Svane, M. S., Martinussen, C., Jørgensen, N. B., Holst, Jens Juul & Madsbad, Sten, Sep 2016, In: Obesity Surgery. 26, 9, p. 2263-7 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass
Dirksen, C., Damgaard, Morten, Bojsen-Møller, K. N., Jørgensen, N. B., Kielgast, U., Jacobsen, S. H., Naver, L. S., Worm, Dorte, Holst, Jens Juul, Madsbad, Sten, Hansen, D. L. & Madsen, J. L., Apr 2013, In: Neurogastroenterology and Motility. 25, 4, p. 346-e255 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass
Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Jacobsen, S. H., Clausen, T. R., Worm, Dorte, Hartmann, Bolette, Rehfeld, Jens Frederik, Damgaard, Morten, Madsen, J. L., Madsbad, Sten, Holst, Jens Juul & Hansen, D. L., 19 Feb 2013, In: International Journal of Obesity. 37, p. 1452-1459 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass
Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2012, In: Diabetologia. 55, 7, p. 1890-901 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial
Dicks, L., Jakobs, L., Sari, M., Hambitzer, R., Ludwig, N., Simon, M., Stehle, P., Stoffel-Wagner, B., Helfrich, H., Ahlborn, J., Rühl, M., Hartmann, Bolette, Holst, Jens Juul & Ellinger, S., 2022, In: European Journal of Nutrition. 61, p. 687–701Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes
Di Giuseppe, G., Soldovieri, L., Ciccarelli, G., Ferraro, P. M., Quero, G., Cinti, F., Capece, U., Moffa, S., Nista, E. C., Gasbarrini, A., Mari, A., Alfieri, S., Tondolo, V., Pontecorvi, A., Holst, Jens Juul, Giaccari, A. & Mezza, T., 2024, In: Journal of Clinical Investigation. 134, 8, 3 p., e175133.Research output: Contribution to journal › Comment/debate › Research
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Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects
Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, Kristine Juul, Christensen, Mikkel Bring, Sonne, D. P., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults
Demant, Mia Grønlund, Suppli, M. P., Foghsgaard, S., Gether, L., Grøndahl, M. F. G., Dalsgaard, N. B., Bergmann, S. S., Lanng, A. R., Gasbjerg, Lærke Smidt, Thomasen, M., Bagger, J. I., Strandberg, C., Kønig, M. J., Grønbæk, H., Becker, U., Holst, Jens Juul, Knop, J., Gillum, M. P., Vilsbøll, Tina & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 23-32Research output: Contribution to journal › Journal article › Research › peer-review
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The incretin/glucagon system as a target for pharmacotherapy of obesity
Del Prato, S., Gallwitz, B., Holst, Jens Juul & Meier, J. J., 2022, In: Obesity Reviews. 23, 2, 13 p., e13372.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy and safety of the glucagon-like peptide-1 receptor agonist liraglutide added to insulin therapy in poorly regulated patients with type 1 diabetes-a protocol for a randomised, double-blind, placebo-controlled study: The Lira-1 study
Dejgaard, T. F., Knop, Filip Krag, Tarnow, L., Frandsen, C. S., Hansen, T. S., Almdal, Thomas Peter, Holst, Jens Juul, Madsbad, Sten & Andersen, H. U., 2015, In: B M J Open. 5, 4, p. 1-8 8 p., e007791.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial
Dejgaard, T. F., Frandsen, C. S., Hansen, T. S., Almdal, Thomas Peter, Urhammer, Søren Asger, Pedersen-Bjergaard, Ulrik, Jensen, T., Jensen, Andreas Kryger, Holst, Jens Juul, Tarnow, L., Knop, Filip Krag, Madsbad, Sten & Andersen, H. U., Mar 2016, In: The Lancet Diabetes & Endocrinology. 4, 3, p. 221–232 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide for treating type 1 diabetes
Dejgaard, T. F., Frandsen, C. S., Holst, Jens Juul & Madsbad, Sten, Apr 2016, In: Expert Opinion on Biological Therapy. 16, 4, p. 579-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial: [Meeting Abstract}
Dejgaard, T. F., Frandsen, C., Kielgast, U., Andersen, H. U., Thorsteinsson, B., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S75-S75 145.Research output: Contribution to journal › Conference abstract in journal › Research
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Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice
Degerman, E., Manganiello, V., Holst, Jens Juul & Ahren, B., 2004, In: Eur. J. Pharmacol.. 498, p. 319-323Research output: Contribution to journal › Journal article › Research › peer-review
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In patients with controlled acromegaly, indices of glucose homeostasis correlate with IGF-1 levels rather than with type of treatment
Decock, A., Verroken, C., Van de Velde, F., Vilsbøll, Tina, Holst, Jens Juul, T’Sjoen, G. & Lapauw, B., 2021, In: Clinical Endocrinology. 95, 1, p. 65-73Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-140 8 p.Research output: Contribution to journal › Review › Research › peer-review
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DPP-4 inhibition – advances in our understanding of diabetes management
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: European Endocrinology. 4, p. 47-49Research output: Contribution to journal › Review › Research
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, Jan 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety
Deacon, Carolyn F. & Holst, Jens Juul, Oct 2013, In: Expert Opinion on Pharmacotherapy. 14, 15, p. 2047-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Deacon, Carolyn F., Ahrén, B. & Holst, Jens Juul, 2004, In: Expert Opinion on Investigational Drugs. 13, 9, p. 1091-102 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes
Deacon, Carolyn F., Carr, R. D. & Holst, Jens Juul, 2008, In: Frontiers in Bioscience. 13, p. 1780-94 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential regional metabolism of glucagon in anesthetized pigs.
Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.
Deacon, Carolyn F. & Holst, Jens Juul, 2005, In: International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Advances in Therapy. 26, 5, p. 488-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
Deacon, Carolyn F., Plamboeck, A., Møller, Søren & Holst, Jens Juul, 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 282, 4, p. E873-9Research output: Contribution to journal › Journal article › Research › peer-review
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GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
Deacon, Carolyn F., Plamboeck, A., Rosenkilde, Mette, de Heer, J. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Deacon, Carolyn F. & Holst, Jens Juul, 2002, In: Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunoassays for the incretin hormones GIP and GLP-1
Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 425-32 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
Deacon, Carolyn F., Nauck, M. A., Meier, J., Hücking, K. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 3575-3581Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human colon produces fully processed glucagon-like peptide-1 (7-36 amide).
Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: FEBS Letters. 372, p. 269-272.Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo.
Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, p. 952-957Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
Deacon, Carolyn F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O. & Holst, Jens Juul, 1998, In: Diabetologia. 41, p. 271-278Research output: Contribution to journal › Journal article › Research › peer-review
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Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects.
Deacon, Carolyn F., Nauck, M. A., Nielsen, M. T., Pridal, L. & Holst, Jens Juul, 1995, In: Diabetes. 44, p. 1126-1131Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In: Diabetes. 50, p. 1588-1597Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.
Deacon, Carolyn F., Hughes, T. E. & Holst, Jens Juul, 1998, In: Diabetes. 47, p. 764-769Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1: A basis for new approaches to the management of Diabetes
Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., 1999, In: Drugs of Today. 35, p. 159-170Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
Deacon, Carolyn F., Wamberg, S., Bie, P., Hughes, T. E. & Holst, Jens Juul, Feb 2002, In: Journal of Endocrinology. 172, 2, p. 355-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1: a basis for new approaches to the management of diabetes
Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., Mar 1999, In: Drugs of Today. 35, 3, p. 159-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Type 2 diabetes mellitus
DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, Jens Juul, Hu, F. B., Kahn, C. R., Raz, I., Shulmann, G. I., Simonson, D. C., Testa, M. A. & Weiss, R., 2015, In: Nature Reviews. Disease Primers. 1, 22 p., 15019.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight
DeBenedictis, J. N., Nymo, S., Ollestad, K. H., Boyesen, G. A., Rehfeld, Jens Frederik, Holst, Jens Juul, Truby, H., Kulseng, B. & Martins, C., 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 7, p. e2538-e2546 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Older subjects with β-cell dysfunction have an accentuated incretin release
De Jesús Garduno-Garcia, J., Gastaldelli, A., DeFronzo, R. A., Lertwattanarak, R., Holst, Jens Juul & Musi, N., 2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 7, p. 2613-2619 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proglucagon cleavage profile in canine L-cells expressing endogenous PC-1/3 and PC-2
Damholt, A. B., Buchan, A. M. J., Holst, Jens Juul & Kofod, H., 1999, In: Endokrinologiya. 140, p. 4800-4808Research output: Contribution to journal › Journal article › Research › peer-review
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Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2
Damholt, A. B., Buchan, A. M., Holst, Jens Juul & Kofod, H., Oct 1999, In: Endocrinology. 140, 10, p. 4800-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of oleic acid and olive oil on gastric emptying, gut hormone secretion and appetite in lean and overweight or obese males
Damgaard, Morten, Graff, J., Fuglsang, S., Holst, Jens Juul, Rehfeld, Jens Frederik & Madsen, J. L., 2013, In: e - S P E N Journal. 8, 1, p. e8-e14 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes
Damgaard, Mads Vargas, Jepsen, Sara Lind, Ashcroft, Stephen Paul, Holst, Jens Juul & Treebak, Jonas Thue, 2022, In: Nutrients. 14, 18, 11 p., 3741.Research output: Contribution to journal › Journal article › Research › peer-review
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Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes
Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Helsted, M. M., Hansen, L. S., Hansen, N. L., Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Bone. 170, 116687.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes
Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients
Dalgaard, M., Thomsen, C., Rasmussen, B. M., Holst, Jens Juul & Hermansen, K., 2004, In: Metabolism. 53, p. 77-83Research output: Contribution to journal › Journal article › Research › peer-review
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Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection
Dahly, E. M., Gillingham, M. B., Guo, Z., Murali, S. G., Nelson, D. W., Holst, Jens Juul & Ney, D. M., Apr 2003, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 284, 4, p. G670-82Research output: Contribution to journal › Journal article › Research › peer-review
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Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid small bowel resection
Dahly, E. M., Gillingham, M. B., Guo, Z., Murali, S. G., Nelson, D. W., Holst, Jens Juul & Ney, D. M., 2003, In: Amer. J. Physiol.. 284, p. G670-G682Research output: Contribution to journal › Journal article › Research › peer-review
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Normal secretion of the incretin hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 during gestational diabetes mellitus
Cypryk, K., Vilsbøll, Tina, Nadel, I., Smyczynska, J., Holst, Jens Juul & Lewinski, A., 2007, In: Gynecological Endocrinology. 23, 1, p. 58-62 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
Creutzfeldt, W. O., Kleine, N., Willms, B., Ørskov, Cathrine, Holst, Jens Juul & Nauck, M. A., Jun 1996, In: Diabetes Care. Supplement. 19, 6, p. 580-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia
Craig, C. M., Liu, L., Deacon, Carolyn F., Holst, Jens Juul & McLaughlin, T. L., Mar 2017, In: Diabetologia. 60, 3, p. 531-540Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass: A Case Report
Craig, C., Lamendola, C., Holst, Jens Juul, Deacon, Carolyn F. & McLaughlin, T., 2015, In: AACE Clinical Case Reports. 1, 2, p. e84-e87 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Salivary ghrelin response to drinks varying in protein content and quantity and association with energy intake and appetite.
Crabtree, D. R., Buosi, W., Fyfe, C. L., Horgan, G. W., Holst, Jens Juul, Johnstone, A. M. & Full4Health-study Group, F. G., 2021, In: Physiology and Behavior. 242, 113622.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project
Crabtree, D. R., Buosi, W., Fyfe, C. L., Horgan, G. W., Manios, Y., Androutsos, O., Giannopoulou, A., Finlayson, G., Beaulieu, K., Meek, C. L., Holst, Jens Juul, Van Norren, K., Mercer, J. G., Johnstone, A. M. & FullHealth Study Grp, F. S. G., 2020, In: Nutrients. 12, 12, 26 p., 3710.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity
Coutinho, S. R., Rehfeld, Jens Frederik, Holst, Jens Juul, Kulseng, B. & Martins, C., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E91-E98Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of fasting duration and weekday in incretin and glucose regulation
Clemmensen, K. K. B., Quist, J. S., Vistisen, D., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Holst, Jens Juul, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Færch, K., 2020, In: Endocrine Connections. 9, 4, p. 279-288Research output: Contribution to journal › Journal article › Research › peer-review
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No effects of dapagliflozin, metformin or exercise on plasma glucagon concentrations in individuals with prediabetes: A post hoc analysis from the randomized controlled PRE-D trial
Clemmensen, K. K. B., Blond, M. B., Amadid, H., Bruhn, L., Vistisen, D., Karstoft, K., Persson, F., Ried-Larsen, M., Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Torekov, Signe Sørensen, Quist, J. S., Jorgensen, M. E. & Faerch, K., 2021, In: Diabetes, Obesity and Metabolism. 23, 2, p. 530-539Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of endogenous hypergastrinemia on gastrin receptor expressing human colon carcinoma transplanted to athymic rats.
Chu, M., Franzén, L., Rehfeld, J. F., Holst, Jens Juul & Borch, K., 1995, In: Today in Medicine. Gastroenterology. 109, p. 1415-1420Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of peptides on anorectal function
Christiansen, J., Lorentzen, M. & Holst, Jens Juul, 1991, In: Annals of Medicine. 22, p. 413-418Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired insulin-stimulated nonoxidative glucose metabolism in pancreas-kidney transplant recipients: dose-response effects of insulin on glucose turnover
Christiansen, E., drb459, drb459, Tibell, A., Hother-Nielsen, O., Holst, Jens Juul, Pedersen, O. & Madsbad, Sten, 1996, In: Diabetes. 45, 9, p. 1267-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolism of oral glucose in pancreas transplant recipients with normal and impaired glucose tolerance.
Christiansen, E., Tibell, A., Vølund, A., Holst, Jens Juul, Rasmussen, K., Schäffer, L. & Madsbad, S., 1997, In: J. Clin. Endocrinol. Metab.. 82, p. 2299-2307Research output: Contribution to journal › Journal article › Research
- Published
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The VGF-Derived Neuropeptide TLQP-21 Shows No Impact on Hormone Secretion in the Isolated Perfused Rat Pancreas
Christiansen, Charlotte Bayer, Svendsen, B. & Holst, Jens Juul, 20 Jan 2015, In: Hormone and Metabolic Research. 47, 07, p. 537-43 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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694
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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