Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

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  • Lund2013

    Submitted manuscript, 367 KB, PDF document

Michael Taulo Lund, Lærke Taudorf, Bolette Hartmann, Jørn Wulff Helge, Jens Juul Holst, Flemming Dela

Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.
Original languageEnglish
JournalEuropean Journal of Applied Physiology
Volume113
Issue number11
Pages (from-to)2737-47
Number of pages11
ISSN1439-6319
DOIs
Publication statusPublished - 1 Nov 2013

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