Thomas Mandrup-Poulsen
Professor
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Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients
Østergaard, H. B., Mandrup-Poulsen, Thomas, Berkelmans, G. F. N., van der Graaf, Y., Visseren, F. L. J. & Westerink, J., 2019, In: Diabetes and Metabolism. 45, 3, p. 254-260 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Zaitseva, I. I., Sharoyko, V., Størling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, Thomas, Nicotera, P., Berggren, P. & Zaitsev, S. V., 2006, In: Biochemical and Biophysical Research Communications. 347, 4, p. 1121-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase
Zaitseva, I. I., Storling, J., Mandrup-Poulsen, Thomas, Berggren, P. O. & Zaitsev, S. V., 2008, In: Cellular and Molecular Life Sciences. 65, 7-8, p. 1248-1255 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection
Wagner, F. F., Lundh, M., Kaya, T., McCarren, P., Zhang, Y-L., Chattopadhyay, S., Gale, J. P., Galbo, T., Fisher, S. L., Meier, B. C., Vetere, A., Richardson, S., Morgan, N. G., Christensen, D. P., Gilbert, T. J., Hooker, J. M., Leroy, M., Walpita, D., Mandrup-Poulsen, T., Wagner, B. K. & 1 others, , 19 Feb 2016, In: ACS chemical biology. 11, 2, p. 363-374 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protection against inflammatory β-cell damage by lysine deacetylase inhibition and microRNA expression?
Vestergaard, A. L., Pallesen, E. M. H., Novotny, G. W., Noesgaard, D., Lundh, M., Regazzi, R. & Mandrup-Poulsen, Thomas, 15 Sep 2015. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells
Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.Research output: Contribution to journal › Comment/debate › Research › peer-review
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MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
Vestergaard, A. L., Bang-Berthelsen, C. H., Floyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., Horskjaer, P. D. H., Frederiksen, K. S., Kofod, F. G., Bruun, C., Berchtold, L. A., Storling, J., Regazzi, R., Kaur, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 27 Sep 2018, In: PLOS ONE. 13, 9, p. 1-22 22 p., e0203713 .Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Ullitz Thorsen, S., Liu, X., Kataria, Y., Mandrup-poulsen, T., Kaur, S., Uusitalo, U., Virtanen, S. M., Norris, J., Rewers, M., Hagopian, W., Yang, J., She, J., Akolkar, B., Rich, S. S., Aronsson, C. A., Lernmark, Å., Ziegler, A., Toppari, J., Krischer, J. P., Parikh, H. M. & 31 others, , 2023, In: Diabetes Care. 46, 5, p. 1-5Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells
Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, Thomas, 2004, In: Endocrinology. 146, 4, p. 1718-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P. & Mandrup-Poulsen, Thomas, 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. & Mandrup-Poulsen, Thomas, 2005, In: Endocrinology. 146, 7, p. 3026-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.
Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, Michala Cecilie Burstein, Berggren, P. & Mandrup-Poulsen, Thomas, Aug 2011, In: Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Obesity-induced changes in gene expression in feline adipose and skeletal muscle tissue
Jensen, Kathrine Stenberg, Novotny, G. W., Lutz, T. A., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2023, In: Journal of Animal Physiology and Animal Nutrition. 107, 5, p. 1262 - 1278Research output: Contribution to journal › Journal article › Research › peer-review
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The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration
Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans
Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells
Sileikaite-Morvaközi, I., Hansen, W. H., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2023, In: International Journal of Molecular Sciences. 24, 19, 13 p., 14585.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of RNA oxidation in islet dysfunction in Type 2 diabetes
Sileikaite, I., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1 , p. S37-S38Research output: Contribution to journal › Conference abstract in journal › Research
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Mitophagy protects beta cells from inflammatory damage in diabetes
Sidarala, V., Pearson, G. L., Parekh, V. S., Thompson, B., Christen, L., Gingerich, M. A., Zhu, J., Stromer, T., Ren, J., Reck, E. C., Chai, B., Corbett, J. A., Mandrup-Poulsen, Thomas, Satin, L. S. & Soleimanpour, S. A., 2020, In: JCI insight. 5, 24, 15 p., 141138.Research output: Contribution to journal › Journal article › Research › peer-review
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The Fas pathway is involved in pancreatic beta cell secretory function.
Schumann, D. M., Maedler, K., Franklin, I., Konrad, D., Størling, J., Böni-Schnetzler, M., Gjinovci, A., Kurrer, M. O., Gauthier, B. R., Bosco, D., Andres, A., Berney, T., Greter, M., Becher, B., Chervonsky, A. V., Halban, P. A., Mandrup-Poulsen, Thomas, Wollheim, C. B. & Donath, M. Y., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 8, p. 2861-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission
Schloot, N. C., Hanifi-Moghaddam, P., Aabenhus-Andersen, N., Alizadeh, B. Z., Saha, M. T., Knip, M., Devendra, D., Wilkin, T., Bonifacio, E., Roep, B. O., Kolb, H. & Mandrup-Poulsen, Thomas, 2007, In: Diabetic Medicine. 24, 5, p. 512-520 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes and suppressors of cytokine signaling proteins.
Rønn, S. G., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetes. 56, 2, p. 541-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection
Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy
Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating endothelial progenitor cell number in long-standing type 1 diabetic patients
Reinhard, H., Jacobsen, P. K., Tarnov, L., Astrup, A. S., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, Thomas, Kastrup, J., Parving, H. H. & Rossing, P., 2008, In: Diabetologia. 51, Suppl. 1, p. S531-S531Research output: Contribution to journal › Journal article › Research › peer-review
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Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes
Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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European Nicotinamide Diabetes Intervention Trial (ENDIT)--sekundaerpublikation. En randomiseret, placebokontrolleret undersøgelse af intervention før debut af type 1-diabetes.
Reimers, J. I., Larsen, C. M., Mandrup-Poulsen, Thomas & European Nicotinamide Diabetes Intervention Trial Group, E. N. D. I. T. G., 2005, In: Ugeskrift for læger. 167, 3, p. 293-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia
Rattanaporn, P., Tongsima, S., Mandrup-Poulsen, Thomas, Svasti, S. & Tanyong, D., 2020, In: PeerJ. 8, e9298.Research output: Contribution to journal › Journal article › Research › peer-review
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JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis
Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.Research output: Contribution to journal › Journal article › Research › peer-review
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TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Størling, Joachim & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.Research output: Contribution to journal › Journal article › Research › peer-review
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RNA modifications by oxidation: a novel disease mechanism?
Poulsen, Henrik Enghusen, Specht, E., Broedbaek, K., Henriksen, T., Ellervik, Christina, Mandrup-Poulsen, Thomas, Tonnesen, M., Nielsen, Peter E., Andersen, H. U. & Weimann, A., Apr 2012, In: Free Radical Biology & Medicine. 52, 8, p. 1353-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The anti-interleukin-1 in type 1 diabetes action trial - Background and rationale
Pickersgill, L. M. S. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 25, 4, p. 321-324 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes
Pham, M., Kolb, H., Battelino, T., Ludvigsson, J., Pozzilli, P., Zivehe, F., Roden, M., Mandrup-Poulsen, Thomas, Schloot, N. C. & European C-Peptide Trial, E. C. T., Jun 2013, In: Diabetologia. 56, 6, p. 1356-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin
Pham, M. N., Kolb, H., Mandrup-Poulsen, Thomas, Battelino, T., Ludvigsson, J., Pozzilli, P., Roden, M., Schloot, N. C. & European C-Peptide Trial, E. C. T., Feb 2013, In: Diabetes - Metabolism: Research and Reviews (Online). 29, 2, p. 166-70 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IL-1β-induced pro-apoptotic signaling is facilitated by NCAM/FGF receptor signaling and inhibited by the C3d ligand in the INS-1E rat beta cell line
Petersen, L. G., Størling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. M. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, p. 1864-75Research output: Contribution to journal › Journal article › Research › peer-review
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IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line
Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Er der dokumentation for Lyrica til behandling af smertende diabetisk neuropati?
Persson, F., Mogensen, C. E. & Mandrup-Poulsen, Thomas, 2005, In: Ugeskrift for læger. 167, 16, p. 1768-9; author reply 1769-70Research output: Contribution to journal › Journal article › Research › peer-review
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Proliferation of sorted human and rat beta cells
Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MicroRNAs as regulators of beta-cell function and dysfunction
Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Ortis, F., Cardozo, A. K., Crispim, D., Störling, J., Mandrup-Poulsen, Thomas & Eizirik, D. L., 2006, In: Molecular Endocrinology. 20, 8, p. 1867-79 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth differences between North American and European children at risk for type 1 diabetes
Nucci, A. M., Becker, D. J., Virtanen, S. M., Cuthbertson, D., Softness, B., Huot, C., Wasikowa, R., Dosch, H. M., Akerblom, H. K., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, Aug 2012, In: Pediatric Diabetes Online. 13, 5, p. 425-31 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional and translational regulation of cytokine signaling in inflammatory ß-cell dysfunction and apoptosis
Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. & Mandrup-Poulsen, Thomas, 2012, In: Archives of Biochemistry and Biophysics. 528, 2, p. 171-84Research output: Contribution to journal › Review › Research › peer-review
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Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia
Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Faroese, a genetic isolate with a strong founder effect, allows the identification of Type 1 diabetes susceptibility regions
Nolsoe, R., Roin, J., Deckert, M., Bergholdt, R., Kelly, J., Brorsson, C., Harley, J., Olsen, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2008, In: Clinical Immunology. 127, Suppl. S, p. S105-S105Research output: Contribution to journal › Journal article › Research › peer-review
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A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection
Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228Research output: Contribution to journal › Journal article › Research › peer-review
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A guiding map for inflammation
Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., Nowak, K. L. & 12 others, , 19 Jul 2017, In: Nature Immunology. 18, 8, p. 826-831 6 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Anti-cytokine therapies in T1D: Concepts and strategies
Nepom, G. T., Ehlers, M. & Mandrup-Poulsen, Thomas, Dec 2013, In: Clinical Immunology. 149, 3 Part A, p. 279-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B. & 12 others, , 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-15 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased Plasma Ferritin Concentration and Low-Grade Inflammation-A Mendelian Randomization Study
Moen, I. W., Bergholdt, H. K. M., Mandrup-Poulsen, Thomas, Nordestgaard, Børge & Ellervik, Christina, 2018, In: Clinical Chemistry. 64, 2, p. 374-385 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case–control ancillary study
Miettinen, M. E., Niinistö, S., Erlund, I., Cuthbertson, D., Nucci, A. M., Honkanen, J., Vaarala, O., Hyöty, H., Krischer, J. P., Knip, M., Virtanen, S. M., Mandrup-Poulsen, Thomas & TRIGR Investigators, T. I., 2020, In: Diabetologia. 63, 4, p. 780-787 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Type 1 diabetes - the copenhagen model
Mandrup-Poulsen, Thomas, Binder, C., Deckert, T. & Nerup, J., 2007, Diabetes og Danmark. 1 ed. Gad, p. 184-195 11 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Interleukin-1-receptor antagonist in type 2 diabetes mellitus - Reply
Mandrup-Poulsen, Thomas, Seifert, B. & Donath, M. Y., 2007, In: New England Journal of Medicine. 357, 3, p. 303-303Research output: Contribution to journal › Journal article › Research › peer-review
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Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No
Mandrup-Poulsen, Thomas, Dec 2017, In: Diabetes. 66, 12, p. 2937-2939 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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Interleukin-1 antagonists for diabetes
Mandrup-Poulsen, Thomas & AIDA study group, A. S. G., Aug 2013, In: Expert Opinion on Investigational Drugs. 22, 8, p. 965-79 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing
Mandrup-Poulsen, Thomas, Feb 2018, In: Nature Reviews Endocrinology. 14, 2, p. 72-74 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glutaminsyre-decarboxylase-antistoffer og diabetes.
Mandrup-Poulsen, Thomas, 2007, In: Ugeskrift for læger. 169, 4, p. 300-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?
Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes. 63, 6, p. 1833-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IAPP boosts islet macrophage IL-1 in type 2 diabetes
Mandrup-Poulsen, Thomas, 1 Oct 2010, In: Nature Immunology. 11, 10, p. 881-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gluten under graviditeten og risiko for type 1 diabetes hos barnet: [Medicinsk nyhed]
Mandrup-Poulsen, Thomas, 2019, In: Ugeskrift for Laeger. 22Research output: Contribution to journal › Comment/debate › Communication
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Type 2 diabetes mellitus: a metabolic autoinflammatory disease
Mandrup-Poulsen, Thomas, Jul 2013, In: Dermatologic Clinics. 31, 3, p. 495-506 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DIAMAP team group. Europe draws up a map to a better future: Diabetes Breakthrough
Mandrup-Poulsen, Thomas, 2009Research output: Other contribution › Communication
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Blockade of Interleukin 1 in Type 1 diabetes mellitus
Mandrup-Poulsen, Thomas, Pickersgill, L. M. S. & Donath, M. Y., 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes
Mandrup-Poulsen, Thomas, 2012, In: The review of diabetic studies : RDS. 9, 4, p. 338-47 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transplantation mellem enaeggede tvillinger
Mandrup-Poulsen, Thomas, 26 Jan 2004, In: Ugeskrift for Laeger. 166, 5, p. 398-9; author reply 399Research output: Contribution to journal › Journal article › Research › peer-review
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Perspective: Testing failures
Mandrup-Poulsen, Thomas, 2012, In: Nature Study. 485, 7398, p. S17Research output: Contribution to journal › Journal article › Commissioned
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Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity
Mandrup-Poulsen, Thomas, Egeberg, J., Nerup, J., Bendtzen, K., Dinarello, C. A. & Nielsen, Jens Høiriis, Apr 1987, In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology. 95, 2, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct effects of cyclosporin A on human pancreatic beta-cells
Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics
Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytokines cause functional and structural damage to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreatic beta-cells respond to fuel pressure with an early metabolic switch
Malinowski, R. M., Ghiasi, S. M., Mandrup-Poulsen, Thomas, Meier, S., Lerche, M. H., Ardenkjaer-Larsen, J. H. & Jensen, P. R., 2020, In: Scientific Reports. 10, 1, 11 p., 15413.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
(19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, Thomas & Donath, M. Y., 2004, In: Diabetes. 53, 7, p. 1706-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-molecule inhibition of inflammatory β-cell death
Lundh, M., Scully, S. S., Mandrup-Poulsen, Thomas & Wagner, B. K., Sep 2013, In: Diabetes, Obesity and Metabolism Online. 15 , 3, p. 176-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats
Lundh, M., Galbo, T., Poulsen, Steen Seier & Mandrup-Poulsen, Thomas, Jul 2015, In: Diabetes, Obesity and Metabolism. 17, 7, p. 703-7 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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The immunoproteasome is induced by cytokines and regulates apoptosis in human islets
Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HDAC3 inhibition rescues pancreatic beta cells from glucolipotoxicity and improves insulin secretion in obese diabetic rats
Lundh, M., Galbo, T., Wagner, F. F., Christensen, D. P., Walpita, D., Gale, J. P., Zhang, Y., Hooker, J., Shulman, G. I., Mandrup-Poulsen, Thomas, Holson, E. B. & Wagner, B. K., Sep 2013, In: Diabetologia. 56, 1 suppl, p. S219-S219Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines
Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
Lundh, M., Christensen, D. P., Damgaard Nielsen, M., Richardson, S. J., Dahllöf, M. S., Skovgaard, T., Berthelsen, J., Dinarello, C. A., Stevenazzi, A., Mascagni, P., Grunnet, Louise Groth, Morgan, N. G. & Mandrup-Poulsen, Thomas, 2012, In: Diabetologia. 55, 9, p. 2421-31Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels Kv7.1 and Kv11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes
Lubberding, Anniek Frederike, Juhl, C. R., Skovhøj, Emil Zeng, Kanters, Jørgen K., Mandrup-Poulsen, Thomas & Torekov, Signe Sørensen, 2022, In: Acta Physiologica. 234, 3, 18 p., 13781.Research output: Contribution to journal › Review › Research › peer-review
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Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.Research output: Contribution to journal › Journal article › Research › peer-review
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The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro
Lewis, E. C., Blaabjerg, L., Størling, Joachim, Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, Thomas, May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of vitamin D supplements during infancy in an international feeding trial
Lehtonen, E., Ormisson, A., Nucci, A., Cuthbertson, D., Sorkio, S., Hyytinen, M., Alahuhta, K., Berseth, C., Salonen, M., Taback, S., Franciscus, M., González-Frutos, T., Korhonen, T. E., Lawson, M. L., Becker, D. J., Krischer, J. P., Knip, M., Virtanen, S. M., TRIGR Investigators, T. I. & Mandrup-Poulsen, Thomas, Apr 2014, In: Public Health Nutrition. 17, 4, p. 810-22 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells
Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
Larsen, L., Tonnesen, M. F., Ronn, S. G., Storling, J., Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetologia. 50, 4, p. 779-789 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells
Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Behandling af diabetes mellitus med biologiske laegemidler.
Larsen, C. M. & Mandrup-Poulsen, Thomas, 2008, In: Ugeskrift for læger. 170, 24, p. 2134-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1 receptorantagonistbehandling af patienter med type 2-diabetes--sekundaerpublikation.
Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M., 2007, In: Ugeskrift for læger. 169, 45, p. 3868-71 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
Larsen, C. M., Faulenbach, M., Vaag, Allan, Ehses, J. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes Care. 32, 9, p. 1663-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M. Y., 2007, In: New England Journal of Medicine. 356, 15, p. 1517-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique
Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No direct effect of SGLT2 activity on glucagon secretion
Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-6 and diabetes: the good, the bad, or the indifferent?
Kristiansen, O. P. & Mandrup-Poulsen, Thomas, 2005, In: Diabetes. 54 Suppl 2, p. S114-24Research output: Contribution to journal › Journal article › Research › peer-review
ID: 923693
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Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice
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212
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
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199
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A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats
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