Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol

    Kleberg, K., Jacobsen, A. K., Ferreira, J. G., Windeløv, Johanne Agerlin, Rehfeld, Jens Frederik, Holst, Jens Juul, de Araujo, I. E. & Hansen, Harald S., 16 Jan 2015, In: The Journal of Physiology. 593, 8, p. 2097-109 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals

    Kliim-Hansen, V., Gether, I. M., Juel, C. T., Ellegaard, A., Pedersen, M. G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Lund, Asger Bach, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2024, In: Peptides. 179, 5 p., 171242.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus

    Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Holst, Jens Juul & Krarup, T., Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis

    Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T. M., 24 Sep 2010, In: Regulatory Peptides. 164, 2-3, p. 144-50 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects

    Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    No reactive hypoglycaemia after subcutaneous administrations of GLP-1 in lean type 2 diabetic patients and in patients with diabeties secondary to chronic pancreatitis

    Knop, F., Vilsbøll, T., Larsen, S., Holst, Jens Juul & Krarup, T., 2003, In: Diabetes Care. 26, p. 2581-2587

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus

    Knop, F. K., Vilsbøll, Tina, Madsbad, Sten, Holst, Jens Juul, Krarup, T., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Holst, J. M. & Krarup, T., 1 Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: Challenges and feasibility

    Knop, F. K., Holst, Jens Juul & Vilsbøll, Tina, 2008, In: IDrugs. The Investigational Drugs Journal. 11, 7, p. 497-501 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility

    Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, T., Jul 2008, In: I Drugs: the Investigational Drugs Journal. 11, 7, p. 497-501 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?

    Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Vølund, A., Holst, Jens Juul & Krarup, T., 2007, In: Diabetes. 56, 8, p. 1951-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Incretin-based therapy of type 2 diabetes mellitus

    Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2009, In: Current Protein and Peptide Science. 10, 1, p. 46-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.

    Knop, F. K., Vilsbøll, Tina, Larsen, S., Højberg, P. V., Vølund, A., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 292, 1, p. E324-30

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency

    Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.

    Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2007, In: Regulatory Peptides. 144, 1-3, p. 123-30 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report

    Knop, Filip Krag, Lund, Asger Bach, Madsbad, Sten, Holst, Jens Juul, Krarup, T. & Vilsbøll, T., 2014, In: BMC Research Notes. 7, p. 1-6 6 p., 326.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

    Knop, Filip Krag, Aaboe, K., Vilsbøll, Tina, Vølund, A., Holst, Jens Juul, Krarup, T. & Madsbad, Sten, 2012, In: Diabetes, Obesity and Metabolism. 14, 6, p. 500-510 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

    Knorr, S., Bytoft, B., Lohse, Z., Boisen, A. B., Clausen, Tine Dalsgaard, Jensen, R. B., Damm, Peter, Beck-Nielsen, H., Holst, Jens Juul, Hartmann, Bolette, Moller, H. J., Hojlund, K., Gravholt, C. H. & Jensen, D. M., 2019, In: Diabetes Care. 42, 8, p. 1560-1568

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation

    Knudsen, K., Hartmann, Bolette, Fedorova, T. D., Østergaard, K., Krogh, K., Møller, N., Holst, Jens Juul & Borghammer, P., 2017, In: Journal of Parkinson's Disease. 7, 4, p. 645-652 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: selection of NN2211 for clinical development

    Knudsen, L. B., Agerso, H., Bjenning, C. & Holst, Jens Juul, 2001, In: Drug Future. 26, p. 677-685

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Small-molecule agonists for the glucagon-like peptide 1 receptor

    Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., Jorgensen, A. S., Kercher, T., Kostrowicki, J., Madsen, P., Olesen, P. H., Petersen, J. S., Poulsen, F., Sidelmann, U. G., Sturis, J., Truesdale, L. & 2 others, May, J. & Lau, J., 16 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 3, p. 937-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes

    Knudsen, S. H., Karstoft, K., Winding, K., Holst, Jens Juul, Pedersen, Bente Klarlund & Solomon, T., Feb 2015, In: Diabetes, Obesity and Metabolism. 17, 2, p. 207-210 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  22. Published

    Differential Effects of Secretin-fragments imply a dual Mechanism of Action for Secretin

    Kofod, H., Thams, P. & Holst, Jens Juul, Feb 1991, In: International Journal of Peptide and Protein Research. 37, 2, p. 134-139 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release

    Kofod, H., Holst, Jens Juul & Lernmark, A., Dec 1988, In: Regulatory Peptides. 23, 3, p. 315-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study

    Koopen, A., Witjes, J., Wortelboer, K., Majait, S., Prodan, A., Levin, E., Herrema, H., Winkelmeijer, M., Aalvink, S., Bergman, J. J. G. H. M., Havik, S., Hartmann, B., Levels, H., Bergh, P-O., van Son, J., Balvers, M., Bastos, D. M., Stroes, E., Groen, A. K., Henricsson, M. & 8 others, Kemper, E. M., Holst, Jens Juul, Strauch, C. M., Hazen, S. L., Backhed, F., De Vos, W. M., Nieuwdorp, M. & Rampanelli, E., 2022, In: Gut. 71, p. 1577-1587 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Effect of fecal microbiota transplantation combined with Mediterranean diet on insulin sensitivity in subjects with metabolic syndrome

    Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., Scheithauer, T. P. M., Frei, W., Dragsted, Lars Ove, Hartmann, Bolette, Holst, Jens Juul, O’Toole, P. W., Groen, A. K. & Nieuwdorp, M., 2021, In: Frontiers in Microbiology. 12, 15 p., 662159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Incretin responses to oral glucose and mixed meal tests and changes in fasting glucose levels during 7 years of follow-up: The Hoorn Meal Study

    Koopman, A. D. M., Rutters, F., Rauh, S. P., Nijpels, G., Holst, Jens Juul, Beulens, J. W., Alssema, M. & Dekker, J. M., 2018, In: PloS one. 13, 1, 13 p., e0191114.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats

    Koopmann, M. C., Nelson, D. W., Murali, S. G., Liu, X. W., Brownfield, M. S., Holst, Jens Juul & Ney, D. M., 2008, In: Journal of Parenteral and Enteral Nutrition. 32, 3, p. 254-265 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats

    Koopmann, M. C., Nelson, D. W., Murali, S. G., Liu, X., Brownfield, M. S., Holst, Jens Juul & Ney, D. M., 30 Apr 2008, In: Journal of Parenteral and Enteral Nutrition. 32, 3, p. 254-65 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome

    Koopmann, M. C., Liu, X., Boehler, C. J., Murali, S. G., Holst, Jens Juul & Ney, D. M., 2009, In: Journal of Parenteral and Enteral Nutrition. 33, 6, p. 629-38; discussion 638-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure

    Koopmann, M. C., Chen, X., Holst, Jens Juul & Ney, D. M., 1 Dec 2010, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 299, 6, p. G1222-30 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding.

    Korner, J., Bessler, M., Inabnet, W., Taveras, C. & Holst, Jens Juul, 2007, In: Surgery for Obesity and Related Diseases. 3, 6, p. 597-601 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes

    Kozawa, J., Okita, K., Imagawa, A., Iwahashi, H., Holst, Jens Juul, Yamagata, K. & Shimomura, I., 12 Mar 2010, In: Biochemical and Biophysical Research Communications. 393, 3, p. 410-3 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effects of a Low-Carbohydrate-High-Protein Pre-Exercise Meal in Type 1 Diabetes—a Randomized Crossover Trial

    Kristensen, K. B., Ranjan, A. G., Mccarthy, O. M., Holst, Jens Juul, Bracken, R. M., Nørgaard, Kirsten & Schmidt, S., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. 208–216 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

    Kristensen, P. L., Pedersen-Bjergaard, Ulrik, Due-Andersen, R., Høi-Hansen, T., Grimmeshave, L., Lyssenko, V., Groop, L., Holst, Jens Juul, Vaag, Allan & Thorsteinsson, B., 2016, In: Endocrine Connections. 5, 6, p. 53-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Influence of erythropoietin on cognitive performance during experimental hypoglycemia in patients with type 1 diabetes mellitus: A Randomized Cross-Over Trial

    Kristensen, Peter Lommer, Pedersen-Bjergaard, Ulrik, Kjær, T. W., Olsen, N. V., Dela, Flemming, Holst, Jens Juul, Faber, Jens, Tarnow, L. & Thorsteinsson, B., 5 Apr 2013, In: P L o S One. 8, 4, p. 1-8 8 p., e59672.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans

    Krog-Mikkelsen, I., Hels, O., Tetens, Inge , Holst, Jens Juul, Andersen, Jens Rikardt & Bukhave, K., 2011, In: American Journal of Clinical Nutrition. 94, 2, p. 472-478 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women

    Krog-Mikkelsen, I., Sloth, B., Dimitrov, D., Tetens, Inge , Björck, I., Flint, A., Holst, Jens Juul, Astrup, A., Elmstähl, H. & Raben, Anne, 2011, In: Journal of Nutrition. 141, 9, p. 1679-1684 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Bone remodeling in survivors of pediatric hematopoietic stem cell transplantation: Impact of heavy resistance training

    Krogh, L. M., Nissen, A., Weischendorff, S., Hartmann, Bolette, Andersen, J. L., Holst, Jens Juul, Sørensen, K., Fridh, M. K., Mackey, Abigail & Muller, Klaus, 2024, In: Medical and Pediatric Oncology. Supplement.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans

    Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Normal physical activity obliterates the deleterious effects of high-caloric intake

    Krogh-Madsen, Rikke, Pedersen, M., Solomon, T., Knudsen, S. H., Hansen, L. S., Karstoft, K., Lehrskov-Schmidt, L., Pedersen, K. K., Thomsen, C., Holst, Jens Juul & Pedersen, Bente Klarlund, 7 Nov 2013, In: Journal of Applied Physiology. 116, 3, p. 231-239 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Repaglinide at a cellular level

    Krogsgaard Thomsen, M., Bokvist, K., Høy, M., Buschard, K., Holst, Jens Juul, Lindström, P. & Gromada, J., Dec 2002, In: Diabetes, nutrition & metabolism. 15, 6 Suppl, p. 15-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    No direct effect of SGLT2 activity on glucagon secretion

    Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?

    Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

    Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

    Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

    Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

    Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

    Research output: Contribution to journal › Journal article › Research › peer-review

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