Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

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Steen Larsen, R Rabøl, C N Hansen, S Madsbad, J W Helge, F Dela

The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind55
Udgave nummer2
Sider (fra-til)443-9
Antal sider7
ISSN0012-186X
DOI
StatusUdgivet - 2012

ID: 40176660