Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Steen Larsen, Carmen Díez-Sánchez, Rasmus Rabøl, Ignacio Ara, Flemming Dela, Jørn Wulff Helge

It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.
OriginalsprogEngelsk
TidsskriftBiochimica et Biophysica Acta - Bioenergetics
Vol/bind1837
Udgave nummer2
Sider (fra-til)226-31
Antal sider6
ISSN0005-2728
DOI
StatusUdgivet - feb. 2014

ID: 106713758