Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. / Larsen, Steen; Díez-Sánchez, Carmen; Rabøl, Rasmus; Ara, Ignacio; Dela, Flemming; Helge, Jørn Wulff.

I: Biochimica et Biophysica Acta - Bioenergetics, Bind 1837, Nr. 2, 02.2014, s. 226-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Larsen, S, Díez-Sánchez, C, Rabøl, R, Ara, I, Dela, F & Helge, JW 2014, 'Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H', Biochimica et Biophysica Acta - Bioenergetics, bind 1837, nr. 2, s. 226-31. https://doi.org/10.1016/j.bbabio.2013.10.009

APA

Larsen, S., Díez-Sánchez, C., Rabøl, R., Ara, I., Dela, F., & Helge, J. W. (2014). Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. Biochimica et Biophysica Acta - Bioenergetics, 1837(2), 226-31. https://doi.org/10.1016/j.bbabio.2013.10.009

Vancouver

Larsen S, Díez-Sánchez C, Rabøl R, Ara I, Dela F, Helge JW. Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. Biochimica et Biophysica Acta - Bioenergetics. 2014 feb;1837(2):226-31. https://doi.org/10.1016/j.bbabio.2013.10.009

Author

Larsen, Steen ; Díez-Sánchez, Carmen ; Rabøl, Rasmus ; Ara, Ignacio ; Dela, Flemming ; Helge, Jørn Wulff. / Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. I: Biochimica et Biophysica Acta - Bioenergetics. 2014 ; Bind 1837, Nr. 2. s. 226-31.

Bibtex

@article{86a665321f0b4e8ebd0ef625d5d910ad,
title = "Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H",
abstract = "It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30{\%} higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.",
keywords = "Citrate (si)-Synthase, Geography, Haplotypes, Humans, Male, Middle Aged, Mitochondria, Muscle Fibers, Skeletal, Oxidative Phosphorylation, Permeability",
author = "Steen Larsen and Carmen D{\'i}ez-S{\'a}nchez and Rasmus Rab{\o}l and Ignacio Ara and Flemming Dela and Helge, {J{\o}rn Wulff}",
note = "{\circledC} 2013.",
year = "2014",
month = "2",
doi = "10.1016/j.bbabio.2013.10.009",
language = "English",
volume = "1837",
pages = "226--31",
journal = "B B A - Bioenergetics",
issn = "0005-2728",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

AU - Larsen, Steen

AU - Díez-Sánchez, Carmen

AU - Rabøl, Rasmus

AU - Ara, Ignacio

AU - Dela, Flemming

AU - Helge, Jørn Wulff

N1 - © 2013.

PY - 2014/2

Y1 - 2014/2

N2 - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

AB - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

KW - Citrate (si)-Synthase

KW - Geography

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitochondria

KW - Muscle Fibers, Skeletal

KW - Oxidative Phosphorylation

KW - Permeability

U2 - 10.1016/j.bbabio.2013.10.009

DO - 10.1016/j.bbabio.2013.10.009

M3 - Journal article

VL - 1837

SP - 226

EP - 231

JO - B B A - Bioenergetics

JF - B B A - Bioenergetics

SN - 0005-2728

IS - 2

ER -

ID: 106713758