Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

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Ann Sophie Lønnberg, Lone Skov, David Lorenzo Duffy, Axel Skytthe, Kirsten Ohm Kyvik, Ole Birger Pedersen, Simon Francis Thomsen

The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

OriginalsprogEngelsk
TidsskriftActa Dermatovenereologica
Vol/bind96
Udgave nummer1
Sider (fra-til)35-8
Antal sider4
ISSN0001-5555
DOI
StatusUdgivet - jan. 2016

ID: 161440810