Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

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Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. / Lønnberg, Ann Sophie; Skov, Lone; Duffy, David Lorenzo; Skytthe, Axel; Kyvik, Kirsten Ohm; Pedersen, Ole Birger; Thomsen, Simon Francis.

I: Acta Dermatovenereologica, Bind 96, Nr. 1, 01.2016, s. 35-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lønnberg, AS, Skov, L, Duffy, DL, Skytthe, A, Kyvik, KO, Pedersen, OB & Thomsen, SF 2016, 'Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study', Acta Dermatovenereologica, bind 96, nr. 1, s. 35-8. https://doi.org/10.2340/00015555-2171

APA

Lønnberg, A. S., Skov, L., Duffy, D. L., Skytthe, A., Kyvik, K. O., Pedersen, O. B., & Thomsen, S. F. (2016). Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study. Acta Dermatovenereologica, 96(1), 35-8. https://doi.org/10.2340/00015555-2171

Vancouver

Lønnberg AS, Skov L, Duffy DL, Skytthe A, Kyvik KO, Pedersen OB o.a. Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study. Acta Dermatovenereologica. 2016 jan;96(1):35-8. https://doi.org/10.2340/00015555-2171

Author

Lønnberg, Ann Sophie ; Skov, Lone ; Duffy, David Lorenzo ; Skytthe, Axel ; Kyvik, Kirsten Ohm ; Pedersen, Ole Birger ; Thomsen, Simon Francis. / Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. I: Acta Dermatovenereologica. 2016 ; Bind 96, Nr. 1. s. 35-8.

Bibtex

@article{a0fc0004da974dcd834f5b0212c5fdb6,
title = "Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study",
abstract = "The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.",
author = "L{\o}nnberg, {Ann Sophie} and Lone Skov and Duffy, {David Lorenzo} and Axel Skytthe and Kyvik, {Kirsten Ohm} and Pedersen, {Ole Birger} and Thomsen, {Simon Francis}",
year = "2016",
month = jan,
doi = "10.2340/00015555-2171",
language = "English",
volume = "96",
pages = "35--8",
journal = "Acta Dermatovenereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic Factors Explain Variation in the Age at Onset of Psoriasis

T2 - A Population-based Twin Study

AU - Lønnberg, Ann Sophie

AU - Skov, Lone

AU - Duffy, David Lorenzo

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Pedersen, Ole Birger

AU - Thomsen, Simon Francis

PY - 2016/1

Y1 - 2016/1

N2 - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

AB - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

U2 - 10.2340/00015555-2171

DO - 10.2340/00015555-2171

M3 - Journal article

C2 - 26073043

VL - 96

SP - 35

EP - 38

JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

SN - 0001-5555

IS - 1

ER -

ID: 161440810