Gustavsson Group – GPCR structure, dynamics and function
We aim to elucidate the molecular details of G protein-coupled receptor (GPCR) receptor function and regulation and translate our findings to biological function and the development of new therapies.
G protein-coupled receptors (GPCRs) relay signals from the outside to the inside of the cell by coupling to G proteins and other intracellular mediators. GPCRs are the targets of around 30% of approved drugs and development of new and therapies is a major focus of academic groups and companies worldwide. In the Gustavsson group, we aim to understand the molecular details of receptor function and regulation and translate our findings to receptor physiology.
We combine characterization of receptor pharmacology in cells and reconstituted systems with characterization of receptor structure and dynamics.
- Protein expression and purification in prokaryotic and eukaryotic systems
- Functional characterization by binding and signaling assays (BRET, FRET, radioligand binding, SPR etc) in cells and reconstituted systems
- Receptor structure and dynamics (cryo-EM, NMR, FRET etc.)
|Fabian Nico Pfersdorf||PhD Student|
|Lucas Romanazzi||Master Student|
|Rajesh Regmi||Laboratory Technician||+4535322006|
|Stefanie Alexandra Eberle||Research Assistant||+4535335040|