EL ALi Group – Lung Physiology and Translational Research
Translational research on lung function, integrating physiology, modeling, and omics to bridge animal and human respiratory studies.
The Lung Physiology and Translational Research Group explores the mechanical, molecular, and computational foundations of respiratory disease. Our work integrates animal lung function testing with advanced statistical modeling, omics analysis, and human clinical data to understand how inflammation, and airway remodeling alter pulmonary mechanics.
The group operates the Animal Lung Function Laboratory equipped with 4 chamber whole-body plethysmography for conscious measurements.
On the clinical side, the group analyzes human spirometry, body plethysmography, and impulse oscillometry (IOS) to develop cross-species models of airway dysfunction. By linking physiological data with transcriptomics and proteomics through collaborations within UCPH, our goal is to identify mechanistic endotypes that connect animal and human respiratory disease, supporting precision approaches in asthma, COPD, and restrictive lung disorders.
- Rodent Whole-body plethysmography (WBP, EMKA)
- Human spirometry, body box, and IOS (TermoFlo C-100)
- Advanced statistical learning modeling and Transcriptomic analysis
- Aerosol and methacholine challenge testing in rodents (WBP)
- Modeling airway mechanics and inflammation across asthma, COPD, and restrictive lung models.
- Transcriptomic data analysis of GEO-derived datasets to identify molecular drivers of airway hyperresponsiveness and inflammation.
- Comparative evaluation of Impulse Oscillometry (IOS) and PD₂₀–FEV₁ responses in clinical methacholine challenge data to determine whether IOS detects airway dysfunction not captured by traditional spirometry.
- Parallel murine methacholine challenge experiments (flexiVent FX2 / NPFE) to assess whether oscillometry-based measures identify early or peripheral airway hyperreactivity more sensitively than forced expiratory indices, thereby strengthening translational mechanistic interpretation.
The group collaborates closely with Professor Jann Mortensen (Rigshospitalet), Dr. Thomas Ringbæk (Allergy and Lung Clinic, Helsingør) and Associate Professor Hannelouise Kissow (Biomedical Institute, Panum).
Group Leader
Henrik EL ALi
Associate Professor
Email: helali@sund.ku.dk
Phone: +45 2935 4867
ORCID: 0000-0001-8226-3055