Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

Professor

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    1 - 100 out of 202Page size: 100
    1. 1985
    2. Published

      Cytokines cause functional and structural damage to isolated islets of Langerhans

      Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 1986
    4. Published

      Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

      Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

      Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

      Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Direct effects of cyclosporin A on human pancreatic beta-cells

      Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 1987
    9. Published

      Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity

      Mandrup-Poulsen, Thomas, Egeberg, J., Nerup, J., Bendtzen, K., Dinarello, C. A. & Nielsen, Jens Høiriis, Apr 1987, In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology. 95, 2, p. 55-63 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics

      Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

      Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 1988
    13. Published

      Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets

      Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration

      Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 1996
    16. Published

      Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine

      Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2003
    18. Published

      Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

      Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. 2004
    20. Published

      Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

      Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, Thomas, 2004, In: Endocrinology. 146, 4, p. 1718-26 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

      Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, Thomas & Donath, M. Y., 2004, In: Diabetes. 53, 7, p. 1706-13 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Type 1 database mellitus: an inflammatory disease of the islet.

      Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Transplantation mellem enaeggede tvillinger

      Mandrup-Poulsen, Thomas, 26 Jan 2004, In: Ugeskrift for Laeger. 166, 5, p. 398-9; author reply 399

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity

      Kristiansen, O. P., Karlsen, A. E., Larsen, Z. M., Johannesen, Jesper, Pociot, Flemming, Mandrup-Poulsen, Thomas & Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood, D. I. E. A. G. G. A. D. S. G. O. I. I. C., 1 Jun 2004, In: Scandinavian Journal of Immunology. 59, 6, p. 582-91 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

      Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2005
    28. Published

      Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

      Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. & Mandrup-Poulsen, Thomas, 2005, In: Endocrinology. 146, 7, p. 3026-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

      Cardozo, A. K., Ortis, F., Storling, J., Feng, Y., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, Thomas, Herchuelz, A. & Eizirik, D. L., 2005, In: Diabetes. 54, 2, p. 452-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Er der dokumentation for Lyrica til behandling af smertende diabetisk neuropati?

      Persson, F., Mogensen, C. E. & Mandrup-Poulsen, Thomas, 2005, In: Ugeskrift for læger. 167, 16, p. 1768-9; author reply 1769-70

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      European Nicotinamide Diabetes Intervention Trial (ENDIT)--sekundaerpublikation. En randomiseret, placebokontrolleret undersøgelse af intervention før debut af type 1-diabetes.

      Reimers, J. I., Larsen, C. M., Mandrup-Poulsen, Thomas & European Nicotinamide Diabetes Intervention Trial Group, E. N. D. I. T. G., 2005, In: Ugeskrift for læger. 167, 3, p. 293-6 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Interleukin-6 and diabetes: the good, the bad, or the indifferent?

      Kristiansen, O. P. & Mandrup-Poulsen, Thomas, 2005, In: Diabetes. 54 Suppl 2, p. S114-24

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

      Gillespie, K. M., Nolsøe, R., Betin, V. M., Kristiansen, O. P., Bingley, P. J., Mandrup-Poulsen, Thomas & Gale, E. A. M., 2005, In: Diabetes. 54, 4, p. 1245-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Poor pregnancy outcome in women with type 2 diabetes

      Clausen, Tine Dalsgaard, Mathiesen, E., Ekbom, P., Hellmuth, E., Mandrup-Poulsen, Thomas & Damm, Peter, 2005, In: Diabetes Care. 28, 2, p. 323-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes

      Hamid, Y. H., Rose, C. S., Urhammer, S. A., Glümer, C., Nolsøe, R., Kristiansen, O. P., Mandrup-Poulsen, Thomas, Borch-Johnsen, K., Jorgensen, T., Hansen, Torben & Pedersen, O., 1 Feb 2005, In: Diabetologia. 48, 2, p. 251-60 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      An immune origin of type 2 diabetes?

      Kolb, H. & Mandrup-Poulsen, Thomas, 1 Jun 2005, In: Diabetologia. 48, 6, p. 1038-50 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

      Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

      Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia

      Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2006
    41. Published

      Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

      Ortis, F., Cardozo, A. K., Crispim, D., Störling, J., Mandrup-Poulsen, Thomas & Eizirik, D. L., 2006, In: Molecular Endocrinology. 20, 8, p. 1867-79 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      IL-1β-induced pro-apoptotic signaling is facilitated by NCAM/FGF receptor signaling and inhibited by the C3d ligand in the INS-1E rat beta cell line

      Petersen, L. G., Størling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. M. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, p. 1864-75

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

      Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.

      Zaitseva, I. I., Sharoyko, V., Størling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, Thomas, Nicotera, P., Berggren, P. & Zaitsev, S. V., 2006, In: Biochemical and Biophysical Research Communications. 347, 4, p. 1121-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.

      Frobøse, H., Rønn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, Thomas & Billestrup, N., 2006, In: Molecular Endocrinology. 20, 7, p. 1587-96 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

      Grunnet, Louise Groth, Poulsen, P., Pedersen, Bente Klarlund, Mandrup-Poulsen, Thomas & Vaag, A., 1 Feb 2006, In: Diabetologia. 49, 2, p. 343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

      Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

      Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Pereira Arias, A. M., Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Prasad, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Mandrup-Poulsen, Thomas, Schloot, N. C., Roep, B. O. & DIABMARKER Study Group, D. S. G., 1 Sep 2006, In: Clinical and Experimental Immunology. 145, 3, p. 480-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. 2007
    50. Published

      Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission

      Schloot, N. C., Hanifi-Moghaddam, P., Aabenhus-Andersen, N., Alizadeh, B. Z., Saha, M. T., Knip, M., Devendra, D., Wilkin, T., Bonifacio, E., Roep, B. O., Kolb, H. & Mandrup-Poulsen, Thomas, 2007, In: Diabetic Medicine. 24, 5, p. 512-520 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Cytokines and beta-cell biology: from concept to clinical translation

      Donath, M. Y., Storling, J., Berchtold, L. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Endocrine Reviews. 29, 3, p. 334-50 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Diabetes and suppressors of cytokine signaling proteins.

      Rønn, S. G., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetes. 56, 2, p. 541-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Glutaminsyre-decarboxylase-antistoffer og diabetes.

      Mandrup-Poulsen, Thomas, 2007, In: Ugeskrift for læger. 169, 4, p. 300-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

      Larsen, L., Tonnesen, M. F., Ronn, S. G., Storling, J., Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetologia. 50, 4, p. 779-789 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Interleukin-1 receptorantagonistbehandling af patienter med type 2-diabetes--sekundaerpublikation.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M., 2007, In: Ugeskrift for læger. 169, 45, p. 3868-71 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus - Reply

      Mandrup-Poulsen, Thomas, Seifert, B. & Donath, M. Y., 2007, In: New England Journal of Medicine. 357, 3, p. 303-303

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, Thomas & Donath, M. Y., 2007, In: New England Journal of Medicine. 356, 15, p. 1517-26 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Lost in translation

      Frank, L. & Mandrup-Poulsen, Thomas, 2007, In: Weekendavisen. 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      The Fas pathway is involved in pancreatic beta cell secretory function.

      Schumann, D. M., Maedler, K., Franklin, I., Konrad, D., Størling, J., Böni-Schnetzler, M., Gjinovci, A., Kurrer, M. O., Gauthier, B. R., Bosco, D., Andres, A., Berney, T., Greter, M., Becher, B., Chervonsky, A. V., Halban, P. A., Mandrup-Poulsen, Thomas, Wollheim, C. B. & Donath, M. Y., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 8, p. 2861-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Type 1 diabetes - the copenhagen model

      Mandrup-Poulsen, Thomas, Binder, C., Deckert, T. & Nerup, J., 2007, Diabetes og Danmark. 1 ed. Gad, p. 184-195 11 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    61. Published

      Ætiologi og patogenese, Type 1

      Bergholdt, R., Larsen, C. M., Pociot, Flemming, Mandrup-Poulsen, Thomas, Hilsted, J. C., Christensen, J. S. & Borch-Johnsen, K., 2007, Diabetes. 1 ed. København: Handelshøjskolens Forlag, Vol. 6. p. -

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    62. Published

      Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

      Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. 2008
    64. Published

      Behandling af diabetes mellitus med biologiske laegemidler.

      Larsen, C. M. & Mandrup-Poulsen, Thomas, 2008, In: Ugeskrift for læger. 170, 24, p. 2134-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Circulating endothelial progenitor cell number in long-standing type 1 diabetic patients

      Reinhard, H., Jacobsen, P. K., Tarnov, L., Astrup, A. S., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, Thomas, Kastrup, J., Parving, H. H. & Rossing, P., 2008, In: Diabetologia. 51, Suppl. 1, p. S531-S531

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

      Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      MicroRNAs are potential posttranscriptional regulators of Bcl-2 family members after cytokine stimulation in INS-1 cells

      Bang-Berthelsen, C. H., Grunnet, L. G., Kutlu, B., Johansson, F., Eizirik, D., Pociot, F. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1, p. 152-152

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.

      Greenbaum, C. J., Mandrup-Poulsen, Thomas, McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., Pozzilli, P., Lachin, J. M., Kolb, H., Type 1 Diabetes Trial Net Research Group, T. 1. D. T. N. R. G. & European C-Peptide Trial Study Group, E. C. T. S. G., 2008, In: Diabetes Care. 31, 10, p. 1966-71 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Proliferation of sorted human and rat beta cells

      Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, Thomas, Billestrup, Nils & Halban, P. A., 2008, In: Diabetologia. 51, 1, p. 91-100 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

      Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      The Faroese, a genetic isolate with a strong founder effect, allows the identification of Type 1 diabetes susceptibility regions

      Nolsoe, R., Roin, J., Deckert, M., Bergholdt, R., Kelly, J., Brorsson, C., Harley, J., Olsen, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2008, In: Clinical Immunology. 127, Suppl. S, p. S105-S105

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

      Zaitseva, I. I., Storling, J., Mandrup-Poulsen, Thomas, Berggren, P. O. & Zaitsev, S. V., 2008, In: Cellular and Molecular Life Sciences. 65, 7-8, p. 1248-1255 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      The role of NCAM signaling in the pancreatic beta-cell

      Grunnet, L. G., Storling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. & Mandrup-Poulsen, Thomas, 2008, In: FEBS Journal. 275, Suppl. 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.

      Donath, M. Y. & Mandrup-Poulsen, Thomas, 2008, In: Nature Clinical Practice Endocrinology & Metabolism. 4, 5, p. 240-1 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. 2009
    76. Published

      Differential transcriptional regulation of extra cellular matrix modulating genes by proinflammatory cytokines in ins-1 cells

      Hansen, J. B., Tonnesen, M., Friberg, J., Brünner, N. & Mandrup-Poulsen, Thomas, 2009. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    77. Published

      Functional SOCS1 polymorphisms are associated with variation in obesity in whites

      Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

      Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

      Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes

      Berchtold, L. A., Larsen, C. M., Vaag, Allan, Faulenbach, M., Workman, C. T., Kruhøffer, M., Donath, M. & Mandrup-Poulsen, Thomas, 2009, In: European Cytokine Network. 20, 2, p. 81-87 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

      Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. Published

      Proinflammatory Cytokines Inhibit TIMP-1 Expression but Induces PAI-1 and CD63 Expression in INS-1 Cells

      Hansen, J. B., Brunner, N. & Mandrup-Poulsen, Thomas, 2009.

      Research output: Contribution to conference › Poster › Research

    83. Published

      Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

      Grunnet, L. G., Aikin, R., Tonnesen, M. F., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L., Billestrup, Nils, Maysinger, D. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes. 58, 8, p. 1807-15 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

      Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

      Larsen, C. M., Faulenbach, M., Vaag, Allan, Ehses, J. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes Care. 32, 9, p. 1663-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      The anti-interleukin-1 in type 1 diabetes action trial - Background and rationale

      Pickersgill, L. M. S. & Mandrup-Poulsen, Thomas, 2009, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 25, 4, p. 321-324 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

      Kolb, H. & Mandrup-Poulsen, Thomas, 2009, In: Diabetologia. 53, 1, p. 10-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

      Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. 2010
    90. Published

      Blockade of Interleukin 1 in Type 1 diabetes mellitus

      Mandrup-Poulsen, Thomas, Pickersgill, L. M. S. & Donath, M. Y., 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS

      Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, Thomas, 2010.

      Research output: Contribution to conference › Conference abstract for conference › Research

    92. Accepted/In press

      Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

      Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).

      Research output: Contribution to conference › Conference abstract for conference › Research

    93. Published

      High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

      Fred, R. G., Bang-Berthelsen, C. H., Mandrup-Poulsen, Thomas, Grunnet, L. G. & Welsh, N., 2010, In: PLoS ONE. 5, 5, p. e10843

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Published

      Role of IL-1beta in type 2 diabetes

      Dinarello, C. A., Donath, M. Y. & Mandrup-Poulsen, Thomas, 1 Aug 2010, In: Current Opinion in Endocrinology, Diabetes and Obesity. 17, 4, p. 314-21 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      IAPP boosts islet macrophage IL-1 in type 2 diabetes

      Mandrup-Poulsen, Thomas, 1 Oct 2010, In: Nature Immunology. 11, 10, p. 881-3 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes

      Reinhard, H., Jacobsen, P. K., Lajer, M., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 1 Oct 2010, In: Diabetologica. 53, 10, p. 2129-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      IL-1 family nomenclature

      Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T. & 14 others, Donath, M., Lewis, E., Pfeilschifter, J., Martin, M., Kracht, M., Muehl, H., Novick, D., Lukic, M., Conti, B., Solinger, A., Kelk, P., Peyman, K., van de Veerdonk, F. & Gabel, C., 1 Nov 2010, In: Nature Immunology. 11, 11, p. 973 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

      Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Dec 2010, In: Diabetologia. 53, 12, p. 2569-78 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. 2011
    100. Published

      Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway

      Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P. & Mandrup-Poulsen, Thomas, 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Published

      Cytokines and type 1 diabetes: a numbers game

      Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Diabetes. 60, 3, p. 697-9 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    102. Published

      Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)

      Knip, M., Virtanen, S. M., Becker, D., Dupré, J., Krischer, J. P., Åkerblom, H. K., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 2011, In: American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1814S-1820S 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. Published

      Elevated transferrin saturation and risk of diabetes: Three population-based studies

      Ellervik, Christina, Mandrup-Poulsen, Thomas, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M., Birgens, H. & Nordestgaard, Børge, 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    104. Published

      Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

      Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Published

      Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

      Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Published

      Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

      Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Published

      The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up

      Akerblom, H. K., Krischer, J., Virtanen, V. S., Berseth, C., Becker, D., Dupré, J., Ilonen, J., Trucco, M., Savilahti, E., Koski, K., Pajakkala, E., Fransiscus, M., Lough, G., Bradley, B., Koski, M., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 1 Mar 2011, In: Diabetologica. 54, 3, p. 627-633 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Published

      The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro

      Lewis, E. C., Blaabjerg, L., Størling, Joachim, Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, Thomas, May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. Published

      16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE

      Bartels, E. M., Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2011, In: Atherosclerosis. Supplement. 12, 1, p. 4 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    110. Published

      Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.

      Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, Michala Cecilie Burstein, Berggren, P. & Mandrup-Poulsen, Thomas, Aug 2011, In: Endocrinology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    111. 2012
    112. Published

      (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

      Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    113. Published

      Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

      Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D. & Mandrup-Poulsen, Thomas, 2012, In: Diabetic Medicine Online. 29, 6, p. 734-741 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. Published

      Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

      Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

      Research output: Contribution to conference › Poster › Research › peer-review

    115. Published

      Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

      Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 923693