Nils Billestrup
Professor
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection
Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells
Bruun, C., Heding, P. E., Rønn, S. G., Frobøse, H., Rhodes, C. J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Molecular and Cellular Endocrinology. 311, 1-2, p. 32-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues
Lundby, A., Bolvig, P., Hegelund, A. C., Hansen, B. F., Worm, J., Lützen, A., Billestrup, Nils, Bonnesen, C. & Oleksiewicz, M. B., Jul 2015, In: Journal of Applied Toxicology. 35, 7, p. 842-850 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice
Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Sørensen, C., Størling, Joachim, Moritz, Thomas, Mariño, E. & Billestrup, Nils, 2023, In: International Journal of Molecular Sciences. 24, 5, 17 p., 4533.Research output: Contribution to journal › Journal article › Research › peer-review
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The Anti-diabetic Effects of GLP-1-gastrin Dual Agonist ZP3022 in ZDF rats
Skarbaliene, J., Secher, T., Jelsing, J., Ansarullah, Neerup, T. S. R., Billestrup, Nils & Fosgerau, K., Jul 2015, In: Peptides. 69, p. 47-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The cellular mechanism of growth hormone signal transduction
Lobie, P. E., Wood, T. J., Sliva, D., Billestrup, Nils, Waters, M. J., Enberg, B. & Norstedt, G., Dec 1994, In: Acta Paediatrica. Supplement. 406, p. 39-46; discussion 47Research output: Contribution to journal › Journal article › Research › peer-review
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The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, Nils, Madsen, O. D., Serup, P., Heimberg, H. & Mansouri, A., 2009, In: Cell. 138, 3, p. 449-62 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells
Rønn, S. G., Hansen, J. A., Lindberg, K., Karlsen, A. E. & Billestrup, Nils, Sep 2002, In: Molecular endocrinology (Baltimore, Md.). 16, 9, p. 2124-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl
Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The role of GH receptor tyrosine phosphorylation in Stat5 activation
Hansen, J. A., Hansen, Lars Hestbjerg, Wang, X., Kopchick, J. J., Gouilleux, F., Groner, B., Møldrup, A., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, Jun 1997, In: Journal of Molecular Endocrinology. 18, 3, p. 213-21 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of growth hormone and prolactin in beta cell growth and regeneration
Nielsen, Jens Høiriis, Møldrup, A., Billestrup, Nils, Petersen, E. D., Allevato, G. & Stahl, M., 1992, Pancreatic islet cell regeneration and growth. Vol. 321. p. 9-17; discussion 19-20 (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation
Richter, H. E., Albrektsen, T. & Billestrup, Nils, Apr 2003, In: Journal of Molecular Endocrinology. 30, 2, p. 139-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH
Smit, L. S., Meyer, D. J., Billestrup, Nils, Norstedt, G., Schwartz, J. & Carter-Su, C., May 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 5, p. 519-33 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I
Billestrup, Nils & Nielsen, Jens Høiriis, Aug 1991, In: Endocrinology. 129, 2, p. 883-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ß-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice
Börjesson, A., Rønn, S. G., Karlsen, A. E., Billestrup, Nils & Sandler, S., 30 Apr 2011, In: Immunology Letters. 136, 1, p. 74-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 15311848
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression
Research output: Contribution to journal › Journal article › Research › peer-review
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38
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Butyrate protects pancreatic beta cells from cytokine-induced dysfunction
Research output: Contribution to journal › Journal article › Research › peer-review
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32
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Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published