Mette Rosenkilde

Mette Rosenkilde

Professor

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    ORCID: 0000-0001-9600-3254

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    1. Published

      2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

      Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection

      Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

      Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, Mette, Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

      Sun, W., Chen, L-N., Zhou, Q., Zhao, L-H., Yang, D., Zhang, H., Cong, Z., Shen, D-D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W. J. C., Zhao, S., Jiang, Y., Rosenkilde, M. M., Xu, H. E., Zhang, Y. & 1 others, Wang, M., 2020, In: Cell Research. 30, 12, p. 1098-1108

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

      Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Acute concomitant GIP receptor antagonism during GLP-1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity

      Stensen, S., Krogh, L. L., wbf943, wbf943, Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 9, p. 1882-1887

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022

      Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

      Research output: Contribution to journal › Editorial › Research › peer-review

    10. Published

      Advances in incretin-based therapeutics for obesity

      Rosenkilde, Mette, 2024, In: Nature Reviews Endocrinology. 20, p. 67–68 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

      Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

      Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial

      Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, E., Xue, K., Giller, K., Becker, S., Mujezinovic, A., Bentzen, Bo Hjorth, Andreas, L. B., Kolocouris, A., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Communications Biology. 4, 10 p., 1347.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

      Madsen, Thomas Daugbjerg, Hansen, L. H., Hintze, John, Ye, Z., Jebari, S., Andersen, Daniel Bjørklund, Joshi, Hiren Jitendra, Ju, T., Goetze, Jens P. , Martin, C., Rosenkilde, Mette, Holst, Jens Juul, Kuhre, Rune Ehrenreich, Goth, C. K., Vakhrushev, Sergey & Schjoldager, Katrine Ter-Borch Gram, 2020, In: Nature Communications. 11, 1, 13 p., 4033.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

      Spiess, Katja, Bagger, Sofie Morsing, Pedersen, Lola Julie Torz, Jensen, Kristian HR, Walser, Anna Louise Silvia, Kvam, J. M., Mogelmose, A. K., Daugvilaite, V., Junnila, R. K., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Annals of the New York Academy of Sciences. 1456, p. 186–199

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28

      Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

      Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

      Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

      Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

      Jørgensen, Astrid Sissel, Daugvilaite, V., De Filippo, K., Berg, Christian, Mavri, M., Benned-Jensen, T., Juzenaite, G., Hjortø, Gertrud Malene, Rankin, S., Vabeno, J. & Rosenkilde, Mette, 2021, In: Communications Biology . 4, 1, 12 p., 569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2

      Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7

      Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Biased and g protein-independent signaling of chemokine receptors

      Steen, A., Larsen, O., Thiele, S. & Rosenkilde, Mette, 2014, In: Frontiers in Immunology. 5, p. 1-13 13 p., 277.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

      Jørgensen, Astrid Sissel, Rosenkilde, Mette & Hjortø, Gertrud Malene, Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

      Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5

      Berg, Christian, Spiess, Katja, von Lüttichau, H. R. & Rosenkilde, Mette, Dec 2016, In: Pharmacology Research & Perspectives. 4, 6, 14 p., e00262.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

      Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Chapter 8. Activation mechanisms of chemokine receptors

      Jensen, P. C. & Rosenkilde, Mette, 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

      Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

      Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

      Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists

      Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    36. Published

      Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes

      Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V

      Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Constitutive and regulated activities of virus-encoded 7TM receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

      Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

    39. Published

      Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

      Zachariassen, Z. G., Thiele, S., Berg, E. A., Rasmussen, P., Fossen, T., Rosenkilde, Mette, Våbenø, J. & Haug, B. E., 1 Sep 2014, In: Bioorganic & Medicinal Chemistry. 22, 17, p. 4759-69 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. E-pub ahead of print

      Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study

      Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

      Thiele, S., Mungalpara, J., Steen, A., Rosenkilde, Mette & Våbenø, J., Dec 2014, In: British Journal of Pharmacology. 171, 23, p. 5313-29 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes

      Berg, Christian, Friis, M. B., Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Lüttichau, H. R. & Sundelin, T., 2019, In: PLoS ONE. 14, 9, 14 p., e0222053.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Development of potent and proteolytically stable human neuromedin U receptor agonists

      De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

      Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Differential regulation of CXCR4 and CCR5 endocytosis

      Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2

      Zweemer, A. J. M., Bunnik, J., Veenhuizen, M., Miraglia, F., Lenselink, E. B., Vilums, M., de Vries, H., Gibert, A., Thiele, S., Rosenkilde, Mette, IJzerman, A. P. & Heitman, L. H., 2014, In: Molecular Pharmacology. 86, 4, p. 358-68 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

      Fares, S., Spiess, Katja, Olesen, Emma Tina Bisgaard, Zuo, J., Jackson, S., Kledal, T. N., Wills, M. R. & Rosenkilde, Mette, 2019, In: mBio. 10, 1, e01707-18.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

      Benned-Jensen, T. & Rosenkilde, Mette, Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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