Mette Rosenkilde

Mette Rosenkilde

Professor

Member of:


    1. 2021
    2. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans

      Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action

      de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

      van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.

      Research output: Contribution to journalConference abstract in journalResearch

    7. Published

      Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

      Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.

      Research output: Contribution to journalConference abstract in journalResearch

    8. Published

      Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

      Yuliantie, E., van der Velden, W. J. C., Labroska, V., Dai, A., Zhao, F., Darbalaei, S., Deganutti, G., Xu, T., Zhou, Q., Yang, D., Rosenkilde, Mette, Sexton, P. M., Wang, M. W. & Wootten, D., 2021, In: Biochemical Pharmacology. 192, 16 p., 114715.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor

      Smit, F. X., van der Velden, W. J. C., Kizilkaya, Hüsün Sheyma, Nørskov, A., Lückmann, Michael, Hansen, T. N., wbf943, wbf943, Qvotrup, K., Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: Structure. 29, 7, p. 679-693.e6 21 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published
    11. Published
    12. Published

      Molecular properties and therapeutic targeting of the ebv-encoded receptor bilf1

      Knerr, J. M., Kledal, T. N. & Rosenkilde, Mette, 2021, In: Cancers. 13, 16, 26 p., 4079.

      Research output: Contribution to journalReviewResearchpeer-review

    13. Published

      Multiple Targets for Oxysterols in Their Regulation of the Immune System

      Reinmuth, L., Hsiao, C. C., Hamann, J., Rosenkilde, Mette & Mackrill, J., 2021, In: Cells. 10, 8, 27 p., 2078.

      Research output: Contribution to journalReviewResearchpeer-review

    14. Published

      Mutational Landscape of the Proglucagon-Derived Peptides

      Lindquist, Peter, Madsen, Jakob Sture, Bräuner, Hans, Rosenkilde, Mette & Hauser, Alexander Sebastian, 2021, In: Frontiers in Endocrinology. 12, 14 p., 698511.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

      Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics

      Paternoster, S., Simpson, P. V., Kokh, E., Kizilkaya, Hüsün Sheyma, Rosenkilde, Mette, Mancera, R. L., Keating, D. J., Massi, M. & Falasca, M., 2021, In: Pharmacological Research. 172, 105822.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

      Tsutsumi, N., Qu, Q., Mavri, M., Baggesen, M. S., Maeda, S., Waghray, D., Berg, Christian, Kobilka, B. K., Rosenkilde, Mette, Skiniotis, G. & Garcia, K. C., 2021, In: Immunity. 54, 7, p. 1405-+ 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: A preliminary study

      Skov-Jeppesen, Kirsa, Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Bone. 152, 7 p., 116065.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

      Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study

      Skov-Jeppesen, Kirsa, Hepp, N., Oeke, J., Hansen, M. S., Jafari Kermani, Abbas, Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, Moustapha Saad El-Deen, Madsbad, Sten, Jensen, Jens-Erik Beck, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Journal of Bone and Mineral Research. 36, 8, p. 1448-1458 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population

      Berg, Christian, Rosenkilde, Mette, Benfield, Thomas, Nielsen, L., Sundelin, T. & Luttichau, H. R., 2021, In: BMC Infectious Diseases. 21, 1, 12 p., 386.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      The role of incretins on insulin function and glucose homeostasis

      Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.

      Research output: Contribution to journalReviewResearchpeer-review

    23. Published

      Effects of endogenous GIP in patients with type 2 diabetes

      Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. 2022
    25. Published

      A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection

      Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published
    27. Published
    28. Published

      Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality

      Mavri, M., Kubale, V., Depledge, D. P., Zuo, J., Huang, C. A., Breuer, J., Vrecl, M., Jarvis, M. A., Jovičić, E. J., Petan, T., Ehlers, B., Rosenkilde, Mette & Spiess, Katja, 2022, In: Frontiers in Endocrinology. 13, 16 p., 862940.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin

      Ribeiro, R. V. P., Ku, T., Wang, A., Pires, L., Ferreira, V. H., Michaelsen, V., Ali, A., Galasso, M., Moshkelgosha, S., Gazzalle, A., Jeppesen, Mads Gravers, Rosenkilde, Mette, Liu, M., Singer, L. G., Kumar, D., Keshavjee, S., Sinclair, J., Kledal, T. N., Humar, A. & Cypel, M., 2022, In: Journal of Heart and Lung Transplantation. 41, 3, p. 287-297

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation

      Mayendraraj, A., Rosenkilde, Mette & Gasbjerg, Lærke Smidt, 2022, In: Peptides. 151, p. 1-10 170749.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal Cavity

      Barington, L., Christensen, Liv von Voss, Pedersen, K. K., Arfelt, K. N., Roumain, M., Jensen, Kristian HR, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, V., Kearney, J. F., Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, G. G., Holst, Peter Johannes & Rosenkilde, Mette, 2022, In: Cells. 11, 3, 19 p., 494.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published
    33. Published

      Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice

      Boer, G. A., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Sparre-Ulrich, A. H., Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4486-4499

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Identification of a conserved chemokine receptor motif that enables ligand discrimination

      Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor

      Rode, A. K. O., Buus, Terkild Brink, Mraz, Veronika, Al-Jaberi, F. A. H., Lopez, D. V., Ford, Shayne Lavondua, Hennen, S., Eliasen, I. P., Klewe, I. V., Gharehdaghi, L., Dragan, A., Rosenkilde, Mette, Woetmann, Anders , Skov, Lone, Ødum, Niels, Bonefeld, Charlotte Menne, Kongsbak-Wismann, Martin & Geisler, Carsten, 2022, In: Cells. 11, 16, 2587.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published
    37. Published

      N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction

      Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats

      Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Reply to: How Many SARS-CoV-2 "Viroporins" Are Really Ion Channels? [Inkl. Correction]

      Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Landbrug, A., Mujezinovic, A., Bentzen, Bo Hjorth, Kledal, T. N. & Rosenkilde, Mette, 2022, In: Communications Biology . 5, 1, 1 p., 860.

      Research output: Contribution to journalLetterResearchpeer-review

    40. Published

      Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

      Brandum, E. P., Jørgensen, Astrid Sissel, Calvo, M. B., Spiess, Katja, Peterson, F. C., Yang, Zhang, Volkman, B. F., Veldkamp, C. T., Rosenkilde, Mette, Goth, C. K. & Hjortø, Gertrud Malene, 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1397.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

      Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

      Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-Terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

      Berg, Christian, Wedemeyer, M. J., Melynis, M., Schlimgen, R. R., Hansen, L. H., Vabenø, J., Peterson, F. C., Volkman, B. F., Rosenkilde, Mette & Lüttichau, H. R., 2022, In: PLOS Pathogens. 18, 3, e1010355.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses

      Rosenkilde, Mette, Tsutsumi, N., Knerr, J. M., Kildedal, Dagmar Fæster & Garcia, K. C., 2022, In: Annual Review of Virology. 9, 1, p. 329-351

      Research output: Contribution to journalReviewResearchpeer-review

    45. 2023
    46. Published

      Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022

      Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

      Research output: Contribution to journalEditorialResearchpeer-review

    47. Published

      Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial

      Weis, Nina, Bollerup, S., Sund, J. D., Glamann, J. B., Vinten, C., Jensen, L. R., Sejling, Christoffer, Kledal, T. N. & Rosenkilde, Mette, 2023, In: Clinical Microbiology and Infection. 29, 10, p. 1313-1319 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

      Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

      Goth, C. K., Mehta, A. Y., McQuillan, A. M., Baker, K. J., Hanes, M. S., Park, S. S., Stavenhagen, K., Hjortø, Gertrud Malene, Heimburg-Molinaro, J., Chaikof, E. L., Rosenkilde, Mette & Cummings, R. D., 2023, In: Cell Chemical Biology. 30, 8, p. 893-905.e7

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

      Hansen, M. S., Soe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, Bolette, Rosenkilde, Mette, Kassem, M., Rauch, A., Gorvin, C. M. & Frost, M., 2023, In: European Journal of Endocrinology. 188, 1, 14 p., 004.

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Published

      GPR162 is a beta cell CART receptor

      Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

      Foo, C. X., Bartlett, S., Chew, K. Y., Ngo, M. D., Bielefeldt-Ohmann, H., Arachchige, B. J., Matthews, B., Reed, S., Wang, R., Smith, C., Sweet, M. J., Burr, L., Bisht, K., Shatunova, S., Sinclair, J. E., Parry, R., Yang, Y., Lévesque, J. P., Khromykh, A., Rosenkilde, M. M. & 2 others, Short, K. R. & Ronacher, K., 2023, In: The European respiratory journal. 61, 3, 15 p., 2201306.

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Glycine: a long-sought novel ligand for GPR158

      Rosenkilde, Mette & Mathiesen, Jesper M., 2023, In: Trends in Pharmacological Sciences. 44, 8, p. 489-491

      Research output: Contribution to journalLetterResearchpeer-review

    ID: 3361