Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
El-Ouaghlidi, A., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., Nov 2007, In: The Journal of clinical endocrinology and metabolism. 92, 11, p. 4165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model
Shang, Q., Liu, M. K., Saumoy, M., Holst, Jens Juul, Salen, G. & Xu, G., 2012, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 302, 8, p. G815-23Research output: Contribution to journal › Journal article › Research › peer-review
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The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: A randomised controlled study
Thomsen, M. N., fbg982, fbg982, Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Samkani, A., 2020, In: Clinical Nutrition ESPEN. 39, p. 46-52 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia
Ahrén, B. & Holst, Jens Juul, 2001, In: Diabetes. 50, p. 1030-1038Research output: Contribution to journal › Journal article › Research › peer-review
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The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss
Asmar, M., Arngrim, N., Simonsen, L., Asmar, A., Nordby, P., Holst, Jens Juul & Bülow, J., 2016, In: Nutrition and Diabetes. 6, 7 p., e208.Research output: Contribution to journal › Journal article › Research › peer-review
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The biology of glucagon and the consequences of hyperglucagonemia
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes
Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369Research output: Contribution to journal › Journal article › Research › peer-review
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The authors reply
Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Kidney International. 85, 1, p. 212-3 2 p.Research output: Contribution to journal › Letter › Research › peer-review
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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin
Tang-Christensen, M., Holst, Jens Juul, Hartmann, B. & Vrang, N., 1999, In: NeuroReport. 10, p. 1183-1187Research output: Contribution to journal › Journal article › Research › peer-review
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The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study
Skov-Jeppesen, Kirsa, Hepp, N., Oeke, J., Hansen, M. S., Jafari Kermani, Abbas, Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, Moustapha Saad El-Deen, Madsbad, Sten, Jensen, Jens-Erik Beck, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Journal of Bone and Mineral Research. 36, 8, p. 1448-1458 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The antagonistic metabolite of GLP-1, GLP-1 (9-36)amide, does not influence gastric emptying and hunger sensations in man
Nagell, C. F., Pedersen, J. F. & Holst, Jens Juul, Jan 2007, In: Scandinavian Journal of Gastroenterology. 42, 1, p. 28-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo.
Toräng, S., Veedfald, Simon, Rosenkilde, Mette, Hartmann, Bolette & Holst, Jens Juul, 20 Jul 2015, In: Physiological Reports. 3, 7, p. 1-8 8 p., e12455.Research output: Contribution to journal › Journal article › Research › peer-review
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The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
de Heer, J., Pedersen, J., Ørskov, Cathrine & Holst, Jens Juul, Oct 2007, In: Diabetologia. 50, 10, p. 2135-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial
Samkani, A., fbg982, fbg982, Anholm, C., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In: Lipids in Health and Disease. 17, 9 p., 295.Research output: Contribution to journal › Journal article › Research › peer-review
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The VGF-Derived Neuropeptide TLQP-21 Shows No Impact on Hormone Secretion in the Isolated Perfused Rat Pancreas
Christiansen, Charlotte Bayer, Svendsen, B. & Holst, Jens Juul, 20 Jan 2015, In: Hormone and Metabolic Research. 47, 07, p. 537-43 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass: A Case Report
Craig, C., Lamendola, C., Holst, Jens Juul, Deacon, Carolyn F. & McLaughlin, T., 2015, In: AACE Clinical Case Reports. 1, 2, p. e84-e87 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest
Alibegovic, A. C., Sonne, M. P., Højbjerre, L., Hansen, T., Pedersen, Oluf Borbye, van Hall, Gerrit, Holst, Jens Juul, Stallknecht, Bente Merete, Dela, Flemming & Vaag, A., 2010, In: Diabetes. 59, 4, p. 836-43 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion
Hjørne, A. P., Modvig, Ida Marie & Holst, Jens Juul, 2022, In: Metabolites. 12, 5, 15 p., 420.Research output: Contribution to journal › Review › Research › peer-review
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The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial
Teysseire, F., Bordier, V., Budzinska, A., Weltens, N., Rehfeld, Jens Frederik, Holst, Jens Juul, Hartmann, Bolette, Beglinger, C., Van Oudenhove, L., Wölnerhanssen, B. K. & Meyer-Gerspach, A. C., 2022, In: Journal of Nutrition. 152, 5, p. 1228–1238,Research output: Contribution to journal › Journal article › Research › peer-review
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The Renal Extraction and the Natriuretic Action of GLP-1 in Humans Depend on Interaction With the GLP-1 Receptor
Asmar, A., Cramon, P. K., Asmar, M., Simonsen, L., Sorensen, Charlotte Mehlin, Madsbad, Sten, Hartmann, Bolette, Holst, Jens Juul, Hovind, P., Jensen, B. L. & Bülow, J., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. e11-e19 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Relationship between Glucagon-Like Peptide 2 and Feeding Intolerance in Preterm Infants.
Ozer, E. A., Holst, Jens Juul, Duman, N., Kumral, A. & Ozkan, H., 2008, In: Journal of Tropical Pediatrics.Research output: Contribution to journal › Journal article › Research › peer-review
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The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection
Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.Research output: Contribution to journal › Journal article › Research › peer-review
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The Liver-Alpha Cell Axis in Health and in Disease
Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861Research output: Contribution to journal › Review › Research › peer-review
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The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner, Hans, 2013, In: Amino Acids. 44, 2, p. 383-390 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Gut: A Key to the Pathogenesis of Type 2 Diabetes?
Holst, Jens Juul, Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer & Knop, Filip Krag, Aug 2017, In: Metabolic Syndrome and Related Disorders. 15, 6, p. 259-262 4 p.Research output: Contribution to journal › Review › Research › peer-review
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The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor
Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes
Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial
Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298Research output: Contribution to journal › Journal article › Research › peer-review
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The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status
Gjesing, A. P., Vestmar, M. A., Jørgensen, T., Heni, M., Holst, Jens Juul, Witte, D. R., Hansen, Torben & Pedersen, Oluf Borbye, 1 Jan 2011, In: P L o S One. 6, 9, p. e23907 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty
Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, Lars Bo, Meisner, S., Hovendahl, C., Vilsbøll, Tina, Knop, Filip Krag & Holst, Jens Juul, 18 Apr 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 304, p. G1117-G1127 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway
't Hart, L. M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L. A., Dekker, J. M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A. P., Palmer, C. N. A., van Haeften, T. W., Herzberg-Schäfer, S. A., Simonis-Bik, A. M. C., Houwing-Duistermaat, J. J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F. & 14 others, , 14 May 2013, In: Diabetes. 62, 9, p. 3275-3281 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs
Simonsen, L., Holst, Jens Juul, Madsen, K. & Deacon, Carolyn F., 10 Feb 2013, In: Regulatory Peptides. 181, 10, p. 17-21 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.
Mandøe, M. J., Hansen, K. B., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul & Hansen, Harald S., 2015, In: The American Journal of Clinical Nutrition. 102, 3, p. 548-555 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Temporal changes in the intestinal growth promoting effects of glucagon-like peptide 2 following intestinal resection
Kaji, T., Tanaka, H., Redstone, H., Wallace, L. E., Holst, Jens Juul & Sigalet, D. L., 2008, In: Journal of Surgical Research. 152, 2, p. 271-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Teduglutide (ALX-0600), a dipeptidyl-peptidase-IV resistant glucagon-like-2 analog improves intestinal function in short bowel syndrome patients
Jeppesen, P. B., Sanguinetti, E. L., Buckman, A., Howard, L., Scolapio, J. S., Ziegler, T. R., Gregory, M., Tappendent, K. A., Holst, Jens Juul & Mortensen, P. B., 2005, In: Gut. 54, p. 1224-1231Research output: Contribution to journal › Journal article › Research
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Targeting the intestinal L-cell for obesity and type 2 diabetes treatment
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 1 Jan 2014, In: Expert Review of Endocrinology & Metabolism. 9, 1, p. 61-72 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins stimulate the release of peptide hormones (glucagon-like peptide-1), and paracrine - (somatostatin) and neurotransmitters (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors
Schmidt, P. T., Rickelt, L. F. & Holst, Jens Juul, 1999, In: Digestive Diseases and Sciences. 44, p. 1273-1281Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins stimulate acid and pepsinogen secretion in the isolated perfused porcine stomach
Schmidt, P. T., Rasmussen, T. N. & Holst, Jens Juul, 1999, In: Acta Physiologica (Print Edition). 166, p. 335-340Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins mediate vagal inhibition of gastrin secretion in pigs
Schmidt, P., Poulsen, Steen Seier, Hilsted, Linda, Rasmussen, T. N. & Holst, Jens Juul, Oct 1996, In: Gastroenterology. 111, 4, p. 925-35 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins in the regulation of gastric motility and secretion
Schmidt, P. T. & Holst, Jens Juul, 2000, In: Review Cellular and Molecular Life Sciences. 57, p. 579-588Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors
Schmidt, P. T., Tornøe, K., Poulsen, Steen Seier, Nygaard, T. & Holst, Jens Juul, 2000, In: Pancreas. 20, p. 241-247Research output: Contribution to journal › Journal article › Research › peer-review
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Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors
Schmidt, P. T., Tornøe, K., Poulsen, Steen Seier, Rasmussen, T. N. & Holst, Jens Juul, Apr 2000, In: Pancreas. 20, 3, p. 241-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?
Gram, D. X., Holst, Jens Juul & Szallasi, A., Nov 2017, In: Trends in Molecular Medicine. 23, 11, p. 1002-1013 12 p.Research output: Contribution to journal › Review › Research › peer-review
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THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology
Mathiesen, D. S., Lund, A., Holst, Jens Juul, Knop, Filip Krag, Lutz, T. A. & Bagger, J. I., 2022, In: European Journal of Endocrinology. 186, 6, p. R93-R111Research output: Contribution to journal › Review › Research › peer-review
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Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery
Li, Q-R., Wang, Z-M., Albrechtsen, N. J. W., Wang, D-D., Su, Z-D., Gao, X-F., Wu, Q-Q., Zhang, H-P., Zhu, L., Li, R-X., Jacobsen, S., Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Petersen, J. S., Madsbad, S., Clausen, T. R., Diderichsen, B., Chen, L-N., Holst, J. J. & 2 others, , 2018, In: EBioMedicine. 28, p. 234-240 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome
Liu, X., Nelson, D. W., Holst, Jens Juul & Ney, D. M., Nov 2006, In: Uden navn. 84, 5, p. 1142-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome
Liu, X. W., Nelson, D. W., Holst, Jens Juul & Ney, D. M., 2006, In: American Journal of Clinical Nutrition. 84, 5, p. 1142-1150 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenocortical steroidogenesis
Ehrhart-Bornstein, M., Bornstein, S. R., Gonzalez-Hernandez, J., Holst, Jens Juul, Watermann, M. R. & Scherbaum, W. A., 1995, In: Endocrine Research. 21, p. 13-24Research output: Contribution to journal › Journal article › Research › peer-review
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Sympathoadrenal regulation of adrenal androstenedione release
Ehrhart-Bornstein, M., Bornstein, S. R., Behling, H. G., Holst, Jens Juul, Strohmayer, H. G., Rasmussen, T. N., Scherbaum, W. A. & Adler, G., 1994, In: Neuroendocrinology. 59, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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