Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

Professor


  1. 2016
  2. Published

    Cytokines and Pancreatic β-Cell Apoptosis

    Berchtold, L. A., Prause, Michala Cecilie Burstein, Størling, Joachim & Mandrup-Poulsen, Thomas, 28 Jun 2016, Advances in Clinical Chemistry. Academic Press, Vol. 75. p. 99-158 60 p. (Advances in Clinical Chemistry, Vol. 75).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Published
  4. Published

    MicroRNAs as regulators of beta-cell function and dysfunction

    Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

    Cabrera, S. M., Wang, X., Chen, Y., Jia, S., Kaldunski, M. L., Greenbaum, C. J., Mandrup-Poulsen, Thomas & Hessner, M. J., Apr 2016, In: European Journal of Immunology. 46, 4, p. 1030-1046 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

    Wagner, F. F., Lundh, M., Kaya, T., McCarren, P., Zhang, Y-L., Chattopadhyay, S., Gale, J. P., Galbo, T., Fisher, S. L., Meier, B. C., Vetere, A., Richardson, S., Morgan, N. G., Christensen, D. P., Gilbert, T. J., Hooker, J. M., Leroy, M., Walpita, D., Mandrup-Poulsen, T., Wagner, B. K. & 1 others, Holson, E. B., 19 Feb 2016, In: ACS chemical biology. 11, 2, p. 363-374 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

    Prause, Michala Cecilie Burstein, Berchtold, L. A., Urizar, A. I., Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas & Størling, Joachim, 15 Jan 2016, In: Molecular and Cellular Endocrinology. 420, p. 24-36 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

    Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.

    Research output: Contribution to journalComment/debateResearchpeer-review

  9. Published

    JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1 beta-Induced Apoptosis Associated with Abrogated Myc Expression

    Prause, Michala Cecilie Burstein, Mayer, C. M., Brorsson, C., Frederiksen, K. S., Billestrup, Nils, Størling, Joachim & Mandrup-Poulsen, Thomas, 2016, In: Journal of Diabetes Research. 2016, 15 p., 1312705.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2015
  11. Published

    Skeletal muscle to pancreatic β-cell cross-talk: the effect of humoral mediators liberated by muscle contraction and acute exercise on β-cell apoptosis

    Christensen, C. S., P. Christensen, D., Lundh, M., Dahllöf, M. S., Haase, T. N., Velasquez, J. M., Laye, M. J., Mandrup-Poulsen, Thomas & Solomon, T. P. J., Oct 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. E1289-E1298 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Protection against inflammatory β-cell damage by lysine deacetylase inhibition and microRNA expression?

    Vestergaard, A. L., Pallesen, E. M. H., Novotny, G. W., Noesgaard, D., Lundh, M., Regazzi, R. & Mandrup-Poulsen, Thomas, 15 Sep 2015. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  13. Published

    ESVE-O-8 A PLACEBO-CONTROLLED STUDY ON THE EFFECT OF THE GLP-1 ANALOGUE, EXENATIDE, ON BODY COMPOSITION, LEPTIN AND ADIPONECTIN IN OBESE, CLIENTOWNED CATS

    Hølmkjær, K. M., Mandrup-Poulsen, Thomas, Nielsen, Dorte Hald, Bjørnvad, Charlotte Reinhard & Cronin, A., Sep 2015, Research Communications of the 25th ECVIM-CA Congress: ECVIM-CA Abstracts. p. 374-375 1 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  14. Published

    Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats

    Lundh, M., Galbo, T., Poulsen, Steen Seier & Mandrup-Poulsen, Thomas, Jul 2015, In: Diabetes, Obesity and Metabolism. 17, 7, p. 703-7 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

    Brandt, C., Hansen, R. H., Hansen, J. B., Olsen, C. H., Galle, P., Mandrup-Poulsen, Thomas, Gehl, Julie, Pedersen, Bente Klarlund & Hojman, P., Feb 2015, In: Metabolism. 64, 2, p. 283-295 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    HDAC Inhibitor-Mediated Beta-Cell Protection Against Cytokine-Induced Toxicity Is STAT1 Tyr701 Phosphorylation Independent

    Dahllöf, M. S., Christensen, D. P., Harving, M., Wagner, B. K., Mandrup-Poulsen, Thomas & Lundh, M., 13 Jan 2015, In: Journal of Interferon & Cytokine Research. 35, 1, p. 63-70 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

    Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  18. Published

    Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice

    Fjære, E., Andersen, C., Myrmel, L. S., Petersen, R. K., Hansen, J. B., Tastesen, H. S., Mandrup-Poulsen, Thomas, Brünner, N., Kristiansen, Karsten, Madsen, L. & Rømer, M. U. K., 2015, In: PloS one. 10, 7, 19 p., e0132910.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2014
  20. Published

    Inhibition of beta cell growth and function by bone morphogenetic proteins

    Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial

    Knip, M., Åkerblom, H. K., Becker, D., Dosch, H., Dupre, J., Fraser, W., Howard, N., Ilonen, J., Krischer, J. P., Kordonouri, O., Lawson, M. L., Palmer, J. P., Savilahti, E., Vaarala, O., Virtanen, S. M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 11 Jun 2014, In: JAMA : the journal of the American Medical Association. 311, 22, p. 2279-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Interleukin-1 antagonism: a sturdy companion for immune tolerance induction in type 1 diabetes?

    Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes. 63, 6, p. 1833-5 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Need for Reclassification of Diabetes Secondary to Iron Overload in the ADA and WHO Classifications

    Ellervik, Christina, Birgens, H. & Mandrup-Poulsen, Thomas, Jun 2014, In: Diabetes Care. 37, 6, p. e137-e138 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

    Bartels, Emil Daniel, Ploug, Thorkil, Størling, Joachim, Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 4, p. 351-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Iron: the hard player in diabetes pathophysiology

    Hansen, J. B., Moen, I. W. & Mandrup-Poulsen, Thomas, Apr 2014, In: Acta Physiologica (Print). 210, 4, p. 717-32 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Recruitment and retention of participants for an international type 1 diabetes prevention trial: a coordinators' perspective

    Franciscus, M., Nucci, A., Bradley, B., Suomalainen, H., Greenberg, E., Laforte, D., Kleemola, P., Hyytinen, M., Salonen, M., Martin, M. J., Catte, D., Catteau, J., TRIGR Investigators, T. I. & Mandrup-Poulsen, Thomas, Apr 2014, In: Clinical Trials. 11, 2, p. 150-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Use of vitamin D supplements during infancy in an international feeding trial

    Lehtonen, E., Ormisson, A., Nucci, A., Cuthbertson, D., Sorkio, S., Hyytinen, M., Alahuhta, K., Berseth, C., Salonen, M., Taback, S., Franciscus, M., González-Frutos, T., Korhonen, T. E., Lawson, M. L., Becker, D. J., Krischer, J. P., Knip, M., Virtanen, S. M., TRIGR Investigators, T. I. & Mandrup-Poulsen, Thomas, Apr 2014, In: Public Health Nutrition. 17, 4, p. 810-22 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Age-dependent decline of beta-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

    Barker, A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W. A., Weets, I., Gorus, F. K., Wareham, N., Leslie, R. D. & Pozzilli, P., Mar 2014, In: Diabetes, Obesity and Metabolism. 16, 3, p. 262-267 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Altering β-cell number through stable alteration of miR-21 and miR-34a expression

    Backe, M. B., Novotny, G. W., Christensen, D. P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 26 Feb 2014, In: Islets. 6, 1, p. 1-8 8 p., e27754.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial

    Hadley, D., Cheung, R. K., Becker, D. J., Girgis, R., Palmer, J. P., Cuthbertson, D., Krischer, J. P., Dosch, H., TRIGR North America Investigators, T. N. A. I. & Mandrup-Poulsen, Thomas, Feb 2014, In: Clinical and Vaccine Immunology (Online). 21, 2, p. 203-11 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

    Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, Mandrup-Poulsen, Thomas, 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist

    Klementiev, B., Li, S., Korshunova, Irina, Dmytriyeva, O., Pankratova, Stanislava, Walmod, P. S., Kjær, L. K., Dahllöf, M. S., Lundh, M., Christensen, D. P., Mandrup-Poulsen, Thomas, Bock, E. & Berezin, V., 2014, In: Journal of Neuroinflammation. 11, 1, p. 27

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J Mice

    Fjære, E., Aune, U. L., Røen, K., Keenan, A. H., Ma, Tao, Borkowski, K., Kristensen, D. M. B., Novotny, G. W., Mandrup-Poulsen, Thomas, Hudson, B. D., Milligan, G., Xi, Y., Newman, J. W., Haj, F. G., Liaset, B., Kristiansen, Karsten & Madsen, L., 2014, In: The Journal of Biological Chemistry. 289, 23, p. 16032-16045 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

    Prause, Michala Cecilie Burstein, Christensen, D. P., Billestrup, Nils & Mandrup-Poulsen, Thomas, 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Obesity related differences in MCP-1 and adiponectin expression in subcutaneous adipose tissue in cats.

    Jensen, Kathrine Stenberg, Novotny, G. W., Mandrup-Poulsen, Thomas & Bjørnvad, Charlotte Reinhard, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  36. 2013
  37. Published

    Anti-cytokine therapies in T1D: Concepts and strategies

    Nepom, G. T., Ehlers, M. & Mandrup-Poulsen, Thomas, Dec 2013, In: Clinical Immunology. 149, 3 Part A, p. 279-85 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Age-dependent decline of β cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

    Barker, V. A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C. J., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W., Weets, I., Gorus, F., Wareham, N., Leslie, R. & Pozzilli, P., 1 Oct 2013, In: Diabetes, Obesity and Metabolism Online. 16, 3, p. 262-267 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    HDAC3 inhibition rescues pancreatic beta cells from glucolipotoxicity and improves insulin secretion in obese diabetic rats

    Lundh, M., Galbo, T., Wagner, F. F., Christensen, D. P., Walpita, D., Gale, J. P., Zhang, Y., Hooker, J., Shulman, G. I., Mandrup-Poulsen, Thomas, Holson, E. B. & Wagner, B. K., Sep 2013, In: Diabetologia. 56, 1 suppl, p. S219-S219

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Small-molecule inhibition of inflammatory β-cell death

    Lundh, M., Scully, S. S., Mandrup-Poulsen, Thomas & Wagner, B. K., Sep 2013, In: Diabetes, Obesity and Metabolism Online. 15 , 3, p. 176-84 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Total mortality by elevated transferrin saturation in patients with diabetes

    Ellervik, Christina, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M. M., Birgens, H., Nordestgaard, Børge & Mandrup-Poulsen, Thomas, Sep 2013, In: Diabetes Care. 36, 9, p. 2646-54 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Interleukin-1 antagonists for diabetes

    Mandrup-Poulsen, Thomas & AIDA study group, A. S. G., Aug 2013, In: Expert Opinion on Investigational Drugs. 22, 8, p. 965-79 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Type 2 diabetes mellitus: a metabolic autoinflammatory disease

    Mandrup-Poulsen, Thomas, Jul 2013, In: Dermatologic Clinics. 31, 3, p. 495-506 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

    Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B. & 12 others, Badenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, Hans, Mandrup-Poulsen, Thomas & Type 1 Diabetes TrialNet Canakinumab Study Group, T. 1. D. T. C. S. G., 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-15 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes

    Pham, M., Kolb, H., Battelino, T., Ludvigsson, J., Pozzilli, P., Zivehe, F., Roden, M., Mandrup-Poulsen, Thomas, Schloot, N. C. & European C-Peptide Trial, E. C. T., Jun 2013, In: Diabetologia. 56, 6, p. 1356-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

    Pham, M. N., Kolb, H., Mandrup-Poulsen, Thomas, Battelino, T., Ludvigsson, J., Pozzilli, P., Roden, M., Schloot, N. C. & European C-Peptide Trial, E. C. T., Feb 2013, In: Diabetes - Metabolism: Research and Reviews (Online). 29, 2, p. 166-70 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2012
  49. Published

    The lysine deacetylase inhibitor givinostat inhibits ß-cell IL-1ß induced IL-1ß transcription and processing

    Dahllöf, M. S., Christensen, D. P., Lundh, M., Dinarello, C. A., Mascagni, P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 1 Nov 2012, In: Islets. 4, 6, p. 417-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

    Engholm-Keller, K., Birck, P., Størling, Joachim, Pociot, Flemming, Mandrup-Poulsen, Thomas & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Growth differences between North American and European children at risk for type 1 diabetes

    Nucci, A. M., Becker, D. J., Virtanen, S. M., Cuthbertson, D., Softness, B., Huot, C., Wasikowa, R., Dosch, H. M., Akerblom, H. K., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, Aug 2012, In: Pediatric Diabetes Online. 13, 5, p. 425-31 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    RNA modifications by oxidation: a novel disease mechanism?

    Poulsen, Henrik Enghusen, Specht, E., Broedbaek, K., Henriksen, T., Ellervik, Christina, Mandrup-Poulsen, Thomas, Tonnesen, M., Nielsen, Peter E., Andersen, H. U. & Weimann, A., Apr 2012, In: Free Radical Biology & Medicine. 52, 8, p. 1353-61 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

    Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

    Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D. & Mandrup-Poulsen, Thomas, 2012, In: Diabetic Medicine Online. 29, 6, p. 734-741 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

    Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

ID: 923693